Delirium Induced by Quetiapine and the Potential Role of Norquetiapine

Detalhes bibliográficos
Autor(a) principal: Almeida, Filipe F.
Data de Publicação: 2019
Outros Autores: Albuquerque, Elisabete, Murta, Ilda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/106966
https://doi.org/10.3389/fnins.2019.00886
Resumo: Quetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in these situations. There is little data published discussing this potential negative impact on quetiapine's safety and tolerability, especially in the elderly. Here, we present what is, to our knowledge, the first published case report of delirium apparently induced by low-dose quetiapine, in a 95-year-old patient with no prior history of mental illness, and the potential role of its metabolite norquetiapine.
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spelling Delirium Induced by Quetiapine and the Potential Role of Norquetiapinedeliriumquetiapineanticholinergicantipsychoticsadverse effectsQuetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in these situations. There is little data published discussing this potential negative impact on quetiapine's safety and tolerability, especially in the elderly. Here, we present what is, to our knowledge, the first published case report of delirium apparently induced by low-dose quetiapine, in a 95-year-old patient with no prior history of mental illness, and the potential role of its metabolite norquetiapine.Frontiers Media S.A.2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106966http://hdl.handle.net/10316/106966https://doi.org/10.3389/fnins.2019.00886eng1662-4548Almeida, Filipe F.Albuquerque, ElisabeteMurta, Ildainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-05-04T11:36:38Zoai:estudogeral.uc.pt:10316/106966Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:21.342279Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
title Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
spellingShingle Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
Almeida, Filipe F.
delirium
quetiapine
anticholinergic
antipsychotics
adverse effects
title_short Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
title_full Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
title_fullStr Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
title_full_unstemmed Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
title_sort Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
author Almeida, Filipe F.
author_facet Almeida, Filipe F.
Albuquerque, Elisabete
Murta, Ilda
author_role author
author2 Albuquerque, Elisabete
Murta, Ilda
author2_role author
author
dc.contributor.author.fl_str_mv Almeida, Filipe F.
Albuquerque, Elisabete
Murta, Ilda
dc.subject.por.fl_str_mv delirium
quetiapine
anticholinergic
antipsychotics
adverse effects
topic delirium
quetiapine
anticholinergic
antipsychotics
adverse effects
description Quetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in these situations. There is little data published discussing this potential negative impact on quetiapine's safety and tolerability, especially in the elderly. Here, we present what is, to our knowledge, the first published case report of delirium apparently induced by low-dose quetiapine, in a 95-year-old patient with no prior history of mental illness, and the potential role of its metabolite norquetiapine.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/106966
http://hdl.handle.net/10316/106966
https://doi.org/10.3389/fnins.2019.00886
url http://hdl.handle.net/10316/106966
https://doi.org/10.3389/fnins.2019.00886
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-4548
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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