Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/164738 |
Resumo: | Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemical parameters including insulin and blood sugar before and after exposure to APDs in order to exclude the involvement of psychiatric disorders and certain other factors in metabolic dysregulations. Fifty seven APDs-naïve patients with first episode psychosis were divided into six groups who received olanzapine, quetiapine, risperidone, aripiprazole, haloperidol or combination of olanzapine with escitalopram and haloperidol. The serum samples were taken before the intake of the first dose and then on follow-up. Decrease in the level of elevated insulin and glucose was observed post-treatment in some patients, while others were observed whose insulin and glucose levels increased post-treatment, yet some patients did not show any disturbance in the insulin and glucose levels. It is concluded that psychiatric disorders by itself, narcotics, cigarette smoking and use of oral snuff may be also be implicated in metabolic dysregulations. The effects of APDs on insulin and glucose in healthy volunteers might be different than in patients with psychiatric disorders. |
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Brazilian Journal of Pharmaceutical Sciences |
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Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugsOlanzapineQuetiapineRisperidoneAntipsychoticsPancreasInsulinAntipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemical parameters including insulin and blood sugar before and after exposure to APDs in order to exclude the involvement of psychiatric disorders and certain other factors in metabolic dysregulations. Fifty seven APDs-naïve patients with first episode psychosis were divided into six groups who received olanzapine, quetiapine, risperidone, aripiprazole, haloperidol or combination of olanzapine with escitalopram and haloperidol. The serum samples were taken before the intake of the first dose and then on follow-up. Decrease in the level of elevated insulin and glucose was observed post-treatment in some patients, while others were observed whose insulin and glucose levels increased post-treatment, yet some patients did not show any disturbance in the insulin and glucose levels. It is concluded that psychiatric disorders by itself, narcotics, cigarette smoking and use of oral snuff may be also be implicated in metabolic dysregulations. The effects of APDs on insulin and glucose in healthy volunteers might be different than in patients with psychiatric disorders.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/16473810.1590/s2175-97902019000117825Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17825Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17825Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e178252175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/164738/157938Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessShah, RehmatSubhan, FazalSultan, Syed MuhammadHaq, MatiulAhmad, HussainKhan, Qasim RiazAli, GowharUllah, SamiUllah, Ihsan2021-01-11T18:10:49Zoai:revistas.usp.br:article/164738Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-11T18:10:49Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs |
title |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs |
spellingShingle |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs Shah, Rehmat Olanzapine Quetiapine Risperidone Antipsychotics Pancreas Insulin |
title_short |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs |
title_full |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs |
title_fullStr |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs |
title_full_unstemmed |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs |
title_sort |
Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs |
author |
Shah, Rehmat |
author_facet |
Shah, Rehmat Subhan, Fazal Sultan, Syed Muhammad Haq, Matiul Ahmad, Hussain Khan, Qasim Riaz Ali, Gowhar Ullah, Sami Ullah, Ihsan |
author_role |
author |
author2 |
Subhan, Fazal Sultan, Syed Muhammad Haq, Matiul Ahmad, Hussain Khan, Qasim Riaz Ali, Gowhar Ullah, Sami Ullah, Ihsan |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Shah, Rehmat Subhan, Fazal Sultan, Syed Muhammad Haq, Matiul Ahmad, Hussain Khan, Qasim Riaz Ali, Gowhar Ullah, Sami Ullah, Ihsan |
dc.subject.por.fl_str_mv |
Olanzapine Quetiapine Risperidone Antipsychotics Pancreas Insulin |
topic |
Olanzapine Quetiapine Risperidone Antipsychotics Pancreas Insulin |
description |
Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemical parameters including insulin and blood sugar before and after exposure to APDs in order to exclude the involvement of psychiatric disorders and certain other factors in metabolic dysregulations. Fifty seven APDs-naïve patients with first episode psychosis were divided into six groups who received olanzapine, quetiapine, risperidone, aripiprazole, haloperidol or combination of olanzapine with escitalopram and haloperidol. The serum samples were taken before the intake of the first dose and then on follow-up. Decrease in the level of elevated insulin and glucose was observed post-treatment in some patients, while others were observed whose insulin and glucose levels increased post-treatment, yet some patients did not show any disturbance in the insulin and glucose levels. It is concluded that psychiatric disorders by itself, narcotics, cigarette smoking and use of oral snuff may be also be implicated in metabolic dysregulations. The effects of APDs on insulin and glucose in healthy volunteers might be different than in patients with psychiatric disorders. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164738 10.1590/s2175-97902019000117825 |
url |
https://www.revistas.usp.br/bjps/article/view/164738 |
identifier_str_mv |
10.1590/s2175-97902019000117825 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164738/157938 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17825 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17825 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17825 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222914473099264 |