Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/56277 |
Resumo: | Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper. |
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Insights into protein-ionic liquid interactions aiming at macromolecule delivery systemsionic liquidsstructural and functional stabilizationprotein stabilitybiopharmaceutical applicationstransdermal drug deliveryFunctional stabilizationStructuralScience & TechnologyOver the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper.Project funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) (FAPESP Refs. No. 2016/08884-3 (Project PneumoPhageColor) and 2016/12234-4 (Project TransAppIL)) is hereby gratefully acknowledged. Funding by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP Ref. No. 2016/16641-3) in the form of an MSc fellowship granted to Liliam Harada is hereby gratefully acknowledged. This work also received support from CNPq, National Council for Scientific and Technological Development, Brazil, in the form of Research Productivity (PQ) fellowships granted to Victor M. Balcão (Refs. No. 306113/2014-7 and 308208/2017-0).info:eu-repo/semantics/publishedVersionSociedade Brasileira de QuímicaUniversidade do MinhoHarada, L. K.Pereira, J. F. B.Campos, W. F.Silva, E. C.Moutinho, Carla G.Vila, Marta M. D. C.Oliveira Jr., J. M.Teixeira, J. A.Balcão, Victor M.Tubino, M.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/56277engHarada, L. K.; Pereira, J. F. B.; Campos, W. F.; Silva, E. C.; Moutinho, Carla G.; Vila, M. M. D. C.; Oliveira, J. M. , Jr.; Teixeira, José A.; Balcão, Victor M.; Tubino, M., Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems. Journal of the Brazilian Chemical Society, 29(10), 1983-1998, 20180103-505310.21577/0103-5053.20180141http://jbcs.sbq.org.brinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:46:03Zoai:repositorium.sdum.uminho.pt:1822/56277Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:43:58.036913Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems |
title |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems |
spellingShingle |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems Harada, L. K. ionic liquids structural and functional stabilization protein stability biopharmaceutical applications transdermal drug delivery Functional stabilization Structural Science & Technology |
title_short |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems |
title_full |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems |
title_fullStr |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems |
title_full_unstemmed |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems |
title_sort |
Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems |
author |
Harada, L. K. |
author_facet |
Harada, L. K. Pereira, J. F. B. Campos, W. F. Silva, E. C. Moutinho, Carla G. Vila, Marta M. D. C. Oliveira Jr., J. M. Teixeira, J. A. Balcão, Victor M. Tubino, M. |
author_role |
author |
author2 |
Pereira, J. F. B. Campos, W. F. Silva, E. C. Moutinho, Carla G. Vila, Marta M. D. C. Oliveira Jr., J. M. Teixeira, J. A. Balcão, Victor M. Tubino, M. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Harada, L. K. Pereira, J. F. B. Campos, W. F. Silva, E. C. Moutinho, Carla G. Vila, Marta M. D. C. Oliveira Jr., J. M. Teixeira, J. A. Balcão, Victor M. Tubino, M. |
dc.subject.por.fl_str_mv |
ionic liquids structural and functional stabilization protein stability biopharmaceutical applications transdermal drug delivery Functional stabilization Structural Science & Technology |
topic |
ionic liquids structural and functional stabilization protein stability biopharmaceutical applications transdermal drug delivery Functional stabilization Structural Science & Technology |
description |
Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/56277 |
url |
http://hdl.handle.net/1822/56277 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Harada, L. K.; Pereira, J. F. B.; Campos, W. F.; Silva, E. C.; Moutinho, Carla G.; Vila, M. M. D. C.; Oliveira, J. M. , Jr.; Teixeira, José A.; Balcão, Victor M.; Tubino, M., Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems. Journal of the Brazilian Chemical Society, 29(10), 1983-1998, 2018 0103-5053 10.21577/0103-5053.20180141 http://jbcs.sbq.org.br |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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