Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems

Detalhes bibliográficos
Autor(a) principal: Harada, Liliam
Data de Publicação: 2018
Outros Autores: Pereira, Jorge, Campos, Welida, Silva, Erica, Moutinho, Carla, Vila, Marta, Oliveira Jr., José, Teixeira, José, Balcão, Victor, Tubino, Matthieu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/8341
Resumo: Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper.
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spelling Insights into protein-ionic liquid interactions aiming at macromolecule delivery systemsIonic liquidsStructural and functional stabilizationProtein stabilityBiopharmaceutical applicationsTransdermal drug deliveryOver the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper.Sociedade Brasileira de QuímicaRepositório Institucional da Universidade Fernando PessoaHarada, LiliamPereira, JorgeCampos, WelidaSilva, EricaMoutinho, CarlaVila, MartaOliveira Jr., JoséTeixeira, JoséBalcão, VictorTubino, Matthieu2019-12-24T12:23:43Z2018-01-01T00:00:00Z2018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/8341engHarada, L. K.; Pereira, J. F. B.; Campos, W. F.; Silva, E. C.; Moutinho, Carla G.; Vila, M. M. D. C.; Oliveira, J. M. , Jr.; Teixeira, José A.; Balcão, Victor M.; Tubino, M., Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems. Journal of the Brazilian Chemical Society, 29(10), 1983-1998, 20180103-505310.21577/0103-5053.20180141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:07:44Zoai:bdigital.ufp.pt:10284/8341Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:45:14.535870Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
title Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
spellingShingle Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
Harada, Liliam
Ionic liquids
Structural and functional stabilization
Protein stability
Biopharmaceutical applications
Transdermal drug delivery
title_short Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
title_full Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
title_fullStr Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
title_full_unstemmed Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
title_sort Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems
author Harada, Liliam
author_facet Harada, Liliam
Pereira, Jorge
Campos, Welida
Silva, Erica
Moutinho, Carla
Vila, Marta
Oliveira Jr., José
Teixeira, José
Balcão, Victor
Tubino, Matthieu
author_role author
author2 Pereira, Jorge
Campos, Welida
Silva, Erica
Moutinho, Carla
Vila, Marta
Oliveira Jr., José
Teixeira, José
Balcão, Victor
Tubino, Matthieu
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Harada, Liliam
Pereira, Jorge
Campos, Welida
Silva, Erica
Moutinho, Carla
Vila, Marta
Oliveira Jr., José
Teixeira, José
Balcão, Victor
Tubino, Matthieu
dc.subject.por.fl_str_mv Ionic liquids
Structural and functional stabilization
Protein stability
Biopharmaceutical applications
Transdermal drug delivery
topic Ionic liquids
Structural and functional stabilization
Protein stability
Biopharmaceutical applications
Transdermal drug delivery
description Over the last few years, researchers have started to explore a particular class of compounds defined as ionic liquids (ILs) in attempts to use their unique characteristics. Since ILs have a very low vapor pressure, these fascinating compounds hold great potential as high performance chemicals for several applications in the (bio)pharmaceutical industry. In general, and unlike common organic solvents with comparable polarities, ILs are quite compatible with enzymes (enhancing their structural and chemical stability) and other proteins, since they can promote higher selectivities, faster reaction rates and greater enzyme stabilities in biocatalytic reactions providing, at the same time, a path for the structural and functional stabilization of protein entities. ILs appear to enhance the delivery of macromolecules, particularly protein entities, and their interactions with ILs will be tackled in detail in this review paper.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01T00:00:00Z
2018-01-01T00:00:00Z
2019-12-24T12:23:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/8341
url http://hdl.handle.net/10284/8341
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Harada, L. K.; Pereira, J. F. B.; Campos, W. F.; Silva, E. C.; Moutinho, Carla G.; Vila, M. M. D. C.; Oliveira, J. M. , Jr.; Teixeira, José A.; Balcão, Victor M.; Tubino, M., Insights into protein-ionic liquid interactions aiming at macromolecule delivery systems. Journal of the Brazilian Chemical Society, 29(10), 1983-1998, 2018
0103-5053
10.21577/0103-5053.20180141
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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