MicroRNAs in lung cancer
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/11885 |
Resumo: | Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this cancer. Current screening methods are focused on identifying the early stages of this malignancy. Thus, new data concerning the roles of microRNA alterations in inflammation, epithelial-mesenchymal transition and lung disease have increased hope about LC pathogenesis, diagnosis, treatment and prognosis. MicroRNA mechanisms include angiogenesis promotion, cell cycle regulation by modulating cellular proliferation and apoptosis, and migration and invasion inhibition. In this context, this manuscript reviews the current information about many important microRNAs as they relate to the initiation and progression of LC. |
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MicroRNAs in lung cancerEpithelial-mesenchymal transitionCigarette-smokeDown-regulationCell-proliferationTumor-metastasisSerum MicrornasExpressionAdenocarcinomaMigrationInvasionLung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this cancer. Current screening methods are focused on identifying the early stages of this malignancy. Thus, new data concerning the roles of microRNA alterations in inflammation, epithelial-mesenchymal transition and lung disease have increased hope about LC pathogenesis, diagnosis, treatment and prognosis. MicroRNA mechanisms include angiogenesis promotion, cell cycle regulation by modulating cellular proliferation and apoptosis, and migration and invasion inhibition. In this context, this manuscript reviews the current information about many important microRNAs as they relate to the initiation and progression of LC.Impact Journals LlcSapientiaCastro, DianaMoreira, MarciaGouveia, Alexandra MonteiroPozza, Daniel HumbertoDe Mello, Ramon Andrade2018-12-07T14:58:09Z2017-102017-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/11885eng1949-255310.18632/oncotarget.20955info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:23:46Zoai:sapientia.ualg.pt:10400.1/11885Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:03:19.603046Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
MicroRNAs in lung cancer |
title |
MicroRNAs in lung cancer |
spellingShingle |
MicroRNAs in lung cancer Castro, Diana Epithelial-mesenchymal transition Cigarette-smoke Down-regulation Cell-proliferation Tumor-metastasis Serum Micrornas Expression Adenocarcinoma Migration Invasion |
title_short |
MicroRNAs in lung cancer |
title_full |
MicroRNAs in lung cancer |
title_fullStr |
MicroRNAs in lung cancer |
title_full_unstemmed |
MicroRNAs in lung cancer |
title_sort |
MicroRNAs in lung cancer |
author |
Castro, Diana |
author_facet |
Castro, Diana Moreira, Marcia Gouveia, Alexandra Monteiro Pozza, Daniel Humberto De Mello, Ramon Andrade |
author_role |
author |
author2 |
Moreira, Marcia Gouveia, Alexandra Monteiro Pozza, Daniel Humberto De Mello, Ramon Andrade |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Castro, Diana Moreira, Marcia Gouveia, Alexandra Monteiro Pozza, Daniel Humberto De Mello, Ramon Andrade |
dc.subject.por.fl_str_mv |
Epithelial-mesenchymal transition Cigarette-smoke Down-regulation Cell-proliferation Tumor-metastasis Serum Micrornas Expression Adenocarcinoma Migration Invasion |
topic |
Epithelial-mesenchymal transition Cigarette-smoke Down-regulation Cell-proliferation Tumor-metastasis Serum Micrornas Expression Adenocarcinoma Migration Invasion |
description |
Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this cancer. Current screening methods are focused on identifying the early stages of this malignancy. Thus, new data concerning the roles of microRNA alterations in inflammation, epithelial-mesenchymal transition and lung disease have increased hope about LC pathogenesis, diagnosis, treatment and prognosis. MicroRNA mechanisms include angiogenesis promotion, cell cycle regulation by modulating cellular proliferation and apoptosis, and migration and invasion inhibition. In this context, this manuscript reviews the current information about many important microRNAs as they relate to the initiation and progression of LC. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10 2017-10-01T00:00:00Z 2018-12-07T14:58:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/11885 |
url |
http://hdl.handle.net/10400.1/11885 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1949-2553 10.18632/oncotarget.20955 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Impact Journals Llc |
publisher.none.fl_str_mv |
Impact Journals Llc |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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