Toxicity of chromated copper arsenate: a study in mice

Detalhes bibliográficos
Autor(a) principal: Matos, Rita Cerejeira
Data de Publicação: 2010
Outros Autores: Vieira, Catarina, Morais, S., Pereira, Maria de Lourdes, Pedrosa, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/3027
Resumo: Chromated copper arsenate (CCA) was widespread used as a chemical wood preservative with application in the construction of playground equipment, fences, jetties, and naval. Environmental protection agency (EPA) had limited the use of CCA-treated wood on 2002, due to probable implications on both human and environmental health. Although this fact, several industries pursue the use of this product within their manufactories. In addition, the durability of this wood for 60 years, makes these treated products an hazard to the public health. In the present work, studies were explored exposing mice to CCA, during 14, 24, 48, and 96 h for the assessment of acute toxicity of CCA. Kidney and liver were removed, prepared for histology and for metalloid, and copper content evaluation by high resolution inductively coupled plasma mass spectroscopy. The histological results evidenced apparently normal structures for control animals and group exposed to As2O5. On the contrary, the renal sections of the animals treated with CCA revealed epithelium cells desquamation, hyaline, and granular casts in renal tubules lumen. Furthermore, high levels of arsenic were detected in the kidney of animals treated with CCA over 14 and 48 h, being significantly greater than controls. Although this approach underlines the potential hazard of CCA on some vital organs, further testing may be required to establish the impacts on other functions.
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spelling Toxicity of chromated copper arsenate: a study in miceCCAKidneyLiverHistochemistryChromated copper arsenate (CCA) was widespread used as a chemical wood preservative with application in the construction of playground equipment, fences, jetties, and naval. Environmental protection agency (EPA) had limited the use of CCA-treated wood on 2002, due to probable implications on both human and environmental health. Although this fact, several industries pursue the use of this product within their manufactories. In addition, the durability of this wood for 60 years, makes these treated products an hazard to the public health. In the present work, studies were explored exposing mice to CCA, during 14, 24, 48, and 96 h for the assessment of acute toxicity of CCA. Kidney and liver were removed, prepared for histology and for metalloid, and copper content evaluation by high resolution inductively coupled plasma mass spectroscopy. The histological results evidenced apparently normal structures for control animals and group exposed to As2O5. On the contrary, the renal sections of the animals treated with CCA revealed epithelium cells desquamation, hyaline, and granular casts in renal tubules lumen. Furthermore, high levels of arsenic were detected in the kidney of animals treated with CCA over 14 and 48 h, being significantly greater than controls. Although this approach underlines the potential hazard of CCA on some vital organs, further testing may be required to establish the impacts on other functions.ElsevierRepositório Científico do Instituto Politécnico do PortoMatos, Rita CerejeiraVieira, CatarinaMorais, S.Pereira, Maria de LourdesPedrosa, J.2013-11-29T12:43:30Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/3027eng0013-935110.1016/j.envres.2010.03.001metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T12:42:49Zoai:recipp.ipp.pt:10400.22/3027Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:24:04.089688Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Toxicity of chromated copper arsenate: a study in mice
title Toxicity of chromated copper arsenate: a study in mice
spellingShingle Toxicity of chromated copper arsenate: a study in mice
Matos, Rita Cerejeira
CCA
Kidney
Liver
Histochemistry
title_short Toxicity of chromated copper arsenate: a study in mice
title_full Toxicity of chromated copper arsenate: a study in mice
title_fullStr Toxicity of chromated copper arsenate: a study in mice
title_full_unstemmed Toxicity of chromated copper arsenate: a study in mice
title_sort Toxicity of chromated copper arsenate: a study in mice
author Matos, Rita Cerejeira
author_facet Matos, Rita Cerejeira
Vieira, Catarina
Morais, S.
Pereira, Maria de Lourdes
Pedrosa, J.
author_role author
author2 Vieira, Catarina
Morais, S.
Pereira, Maria de Lourdes
Pedrosa, J.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Matos, Rita Cerejeira
Vieira, Catarina
Morais, S.
Pereira, Maria de Lourdes
Pedrosa, J.
dc.subject.por.fl_str_mv CCA
Kidney
Liver
Histochemistry
topic CCA
Kidney
Liver
Histochemistry
description Chromated copper arsenate (CCA) was widespread used as a chemical wood preservative with application in the construction of playground equipment, fences, jetties, and naval. Environmental protection agency (EPA) had limited the use of CCA-treated wood on 2002, due to probable implications on both human and environmental health. Although this fact, several industries pursue the use of this product within their manufactories. In addition, the durability of this wood for 60 years, makes these treated products an hazard to the public health. In the present work, studies were explored exposing mice to CCA, during 14, 24, 48, and 96 h for the assessment of acute toxicity of CCA. Kidney and liver were removed, prepared for histology and for metalloid, and copper content evaluation by high resolution inductively coupled plasma mass spectroscopy. The histological results evidenced apparently normal structures for control animals and group exposed to As2O5. On the contrary, the renal sections of the animals treated with CCA revealed epithelium cells desquamation, hyaline, and granular casts in renal tubules lumen. Furthermore, high levels of arsenic were detected in the kidney of animals treated with CCA over 14 and 48 h, being significantly greater than controls. Although this approach underlines the potential hazard of CCA on some vital organs, further testing may be required to establish the impacts on other functions.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2013-11-29T12:43:30Z
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10.1016/j.envres.2010.03.001
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dc.publisher.none.fl_str_mv Elsevier
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