Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/44867 |
Resumo: | Salvia officinalis and some of its isolated compounds have been found to be preventive of DNA damage and increased proliferation in vitro in colon cells. In the present study, we used the azoxymethane model to test effects of S. officinalis on colon cancer prevention in vivo. The results showed that sage treatment reduced the number of ACF formed only if administered before azoxymethane injection, demonstrating that sage tea drinking has a chemopreventive effect on colorectal cancer. A decrease in the proliferation marker Ki67 and in H2O2-induced and azoxymethane-induced DNA damage to colonocytes and lymphocytes were found with sage treatment. This confirms in vivo the chemopreventive effects of S. officinalis. Taken together, our results show that sage treatment prevented initiation phases of colon carcinogenesis, an effect due, at least in part, to DNA protection, and reduced proliferation rates of colon epithelial cell that prevent mutations and their fixation through cell replication. These chemopreventive effects of S. officinalis on colon cancer add to the many health benefits attributed to sage and encourage its consumption. |
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Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferationSalvia officinalis teaColon cancerDNA damageComet assayScience & TechnologySalvia officinalis and some of its isolated compounds have been found to be preventive of DNA damage and increased proliferation in vitro in colon cells. In the present study, we used the azoxymethane model to test effects of S. officinalis on colon cancer prevention in vivo. The results showed that sage treatment reduced the number of ACF formed only if administered before azoxymethane injection, demonstrating that sage tea drinking has a chemopreventive effect on colorectal cancer. A decrease in the proliferation marker Ki67 and in H2O2-induced and azoxymethane-induced DNA damage to colonocytes and lymphocytes were found with sage treatment. This confirms in vivo the chemopreventive effects of S. officinalis. Taken together, our results show that sage treatment prevented initiation phases of colon carcinogenesis, an effect due, at least in part, to DNA protection, and reduced proliferation rates of colon epithelial cell that prevent mutations and their fixation through cell replication. These chemopreventive effects of S. officinalis on colon cancer add to the many health benefits attributed to sage and encourage its consumption.Fundação para a Ciência e a Tecnologia (FCT) - grant SFRH/BD/35672/2007, SFRH/BD/64817/2009John Wiley and SonsUniversidade do MinhoPedro, Dalila F. N.Ramos, Alice Fernanda AbreuLima, Cristóvão Fernando MacedoBaltazar, FátimaWilson, Cristina Pereira20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/44867eng0951-418X1099-157310.1002/ptr.553126661587http://onlinelibrary.wiley.com/doi/10.1002/ptr.5531/abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:50:15Zoai:repositorium.sdum.uminho.pt:1822/44867Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:48:54.822366Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation |
title |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation |
spellingShingle |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation Pedro, Dalila F. N. Salvia officinalis tea Colon cancer DNA damage Comet assay Science & Technology |
title_short |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation |
title_full |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation |
title_fullStr |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation |
title_full_unstemmed |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation |
title_sort |
Colon cancer chemoprevention by sage tea drinking: decreased DNA damage and cell proliferation |
author |
Pedro, Dalila F. N. |
author_facet |
Pedro, Dalila F. N. Ramos, Alice Fernanda Abreu Lima, Cristóvão Fernando Macedo Baltazar, Fátima Wilson, Cristina Pereira |
author_role |
author |
author2 |
Ramos, Alice Fernanda Abreu Lima, Cristóvão Fernando Macedo Baltazar, Fátima Wilson, Cristina Pereira |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pedro, Dalila F. N. Ramos, Alice Fernanda Abreu Lima, Cristóvão Fernando Macedo Baltazar, Fátima Wilson, Cristina Pereira |
dc.subject.por.fl_str_mv |
Salvia officinalis tea Colon cancer DNA damage Comet assay Science & Technology |
topic |
Salvia officinalis tea Colon cancer DNA damage Comet assay Science & Technology |
description |
Salvia officinalis and some of its isolated compounds have been found to be preventive of DNA damage and increased proliferation in vitro in colon cells. In the present study, we used the azoxymethane model to test effects of S. officinalis on colon cancer prevention in vivo. The results showed that sage treatment reduced the number of ACF formed only if administered before azoxymethane injection, demonstrating that sage tea drinking has a chemopreventive effect on colorectal cancer. A decrease in the proliferation marker Ki67 and in H2O2-induced and azoxymethane-induced DNA damage to colonocytes and lymphocytes were found with sage treatment. This confirms in vivo the chemopreventive effects of S. officinalis. Taken together, our results show that sage treatment prevented initiation phases of colon carcinogenesis, an effect due, at least in part, to DNA protection, and reduced proliferation rates of colon epithelial cell that prevent mutations and their fixation through cell replication. These chemopreventive effects of S. officinalis on colon cancer add to the many health benefits attributed to sage and encourage its consumption. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/44867 |
url |
http://hdl.handle.net/1822/44867 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0951-418X 1099-1573 10.1002/ptr.5531 26661587 http://onlinelibrary.wiley.com/doi/10.1002/ptr.5531/abstract |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley and Sons |
publisher.none.fl_str_mv |
John Wiley and Sons |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133068446924800 |