ATP as a multi-target danger signal in the brain

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Ricardo J.
Data de Publicação: 2015
Outros Autores: Tomé, Ângelo R., Cunha, Rodrigo A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/109156
https://doi.org/10.3389/fnins.2015.00148
Resumo: ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2 receptors (P2R) as well as adenosine receptors upon extracellular ATP catabolism by ecto-nucleotidases. Notably, brain noxious stimuli trigger a sustained increase of extracellular ATP, which plays a key role as danger signal in the brain. This involves a combined action of extracellular ATP in different cell types, namely increasing the susceptibility of neurons to damage, promoting astrogliosis and recruiting and formatting microglia to mount neuroinflammatory responses. Such actions involve the activation of different receptors, as heralded by neuroprotective effects resulting from blockade mainly of P2X7R, P2Y1R and adenosine A2A receptors (A2AR), which hierarchy, cooperation and/or redundancy is still not resolved. These pleiotropic functions of ATP as a danger signal in brain damage prompt a therapeutic interest to multi-target different purinergic receptors to provide maximal opportunities for neuroprotection.
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spelling ATP as a multi-target danger signal in the brainATPadenosineP2 receptorsP1 receptorsecto-nucleotidasesP2X7 receptorP2Y1 receptorA2A receptorATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2 receptors (P2R) as well as adenosine receptors upon extracellular ATP catabolism by ecto-nucleotidases. Notably, brain noxious stimuli trigger a sustained increase of extracellular ATP, which plays a key role as danger signal in the brain. This involves a combined action of extracellular ATP in different cell types, namely increasing the susceptibility of neurons to damage, promoting astrogliosis and recruiting and formatting microglia to mount neuroinflammatory responses. Such actions involve the activation of different receptors, as heralded by neuroprotective effects resulting from blockade mainly of P2X7R, P2Y1R and adenosine A2A receptors (A2AR), which hierarchy, cooperation and/or redundancy is still not resolved. These pleiotropic functions of ATP as a danger signal in brain damage prompt a therapeutic interest to multi-target different purinergic receptors to provide maximal opportunities for neuroprotection.Frontiers Media S.A.2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109156http://hdl.handle.net/10316/109156https://doi.org/10.3389/fnins.2015.00148eng1662-4548Rodrigues, Ricardo J.Tomé, Ângelo R.Cunha, Rodrigo A.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-29T09:03:31Zoai:estudogeral.uc.pt:10316/109156Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:21.261059Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv ATP as a multi-target danger signal in the brain
title ATP as a multi-target danger signal in the brain
spellingShingle ATP as a multi-target danger signal in the brain
Rodrigues, Ricardo J.
ATP
adenosine
P2 receptors
P1 receptors
ecto-nucleotidases
P2X7 receptor
P2Y1 receptor
A2A receptor
title_short ATP as a multi-target danger signal in the brain
title_full ATP as a multi-target danger signal in the brain
title_fullStr ATP as a multi-target danger signal in the brain
title_full_unstemmed ATP as a multi-target danger signal in the brain
title_sort ATP as a multi-target danger signal in the brain
author Rodrigues, Ricardo J.
author_facet Rodrigues, Ricardo J.
Tomé, Ângelo R.
Cunha, Rodrigo A.
author_role author
author2 Tomé, Ângelo R.
Cunha, Rodrigo A.
author2_role author
author
dc.contributor.author.fl_str_mv Rodrigues, Ricardo J.
Tomé, Ângelo R.
Cunha, Rodrigo A.
dc.subject.por.fl_str_mv ATP
adenosine
P2 receptors
P1 receptors
ecto-nucleotidases
P2X7 receptor
P2Y1 receptor
A2A receptor
topic ATP
adenosine
P2 receptors
P1 receptors
ecto-nucleotidases
P2X7 receptor
P2Y1 receptor
A2A receptor
description ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2 receptors (P2R) as well as adenosine receptors upon extracellular ATP catabolism by ecto-nucleotidases. Notably, brain noxious stimuli trigger a sustained increase of extracellular ATP, which plays a key role as danger signal in the brain. This involves a combined action of extracellular ATP in different cell types, namely increasing the susceptibility of neurons to damage, promoting astrogliosis and recruiting and formatting microglia to mount neuroinflammatory responses. Such actions involve the activation of different receptors, as heralded by neuroprotective effects resulting from blockade mainly of P2X7R, P2Y1R and adenosine A2A receptors (A2AR), which hierarchy, cooperation and/or redundancy is still not resolved. These pleiotropic functions of ATP as a danger signal in brain damage prompt a therapeutic interest to multi-target different purinergic receptors to provide maximal opportunities for neuroprotection.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109156
http://hdl.handle.net/10316/109156
https://doi.org/10.3389/fnins.2015.00148
url http://hdl.handle.net/10316/109156
https://doi.org/10.3389/fnins.2015.00148
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1662-4548
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dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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