The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells

Detalhes bibliográficos
Autor(a) principal: Jasiński, Tomasz
Data de Publicação: 2022
Outros Autores: Zdrojkowski, Łukasz, Kautz, Ewa, Juszczuk- Kubiak, Edyta, Ferreira-Dias, Graça, Domino, Małgorzata
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/25304
Resumo: Research Areas: Agriculture ; Reproductive Biology ; Veterinary Sciences
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spelling The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cellsEndometritisHASIL-6MareMCP-1NF-kappa BResearch Areas: Agriculture ; Reproductive Biology ; Veterinary SciencesABSTRACT: Endometritis is an important issue decreasing mares' fertility. In the case of endo-metritis, both inflammatory cells infiltration and proinflammatory molecules produc-tion are regulated by various cellular and gene regulatory mechanisms, including the nuclear factor- κB (NF- κB)- dependent pathway. NF- κB- signalling pathway has been recently studied in the equine endometrium in the context of endometrosis. Thus, this study aimed to determine gene transcription of NF- κB subunits (RelA; NF- κB1; NF- κB2), proinflammatory molecules (M C P - 1 ; I L- 6) and hyaluronan synthases (HAS 1; HAS 2; HAS 3) in endometritis and compare them with the intensity and type of inflamma-tory cell infiltration. Endometrial samples, collected post- mortem from cyclic mares in oestrus or dioestrus, were classified histologically and examined using quantitative PCR. Transcription NF- κB subunits genes did not differ with either inflammatory in-tensity or type of inflammatory cell infiltration. Transcription of M C P - 1 and I L- 6 genes increased with the severity of inflammation, with the involvement of HAS 3 and HAS 2 genes, as opposed to HAS 1 genes. These proinflammatory molecules and hyaluronan synthases in the equine inflamed endometrium do not seem to be regulated by the NF- κB pathway. Hence, separate signalling pathways for the development and pro-gression of equine endometritis and endometrosis may be suggestedWileyRepositório da Universidade de LisboaJasiński, TomaszZdrojkowski, ŁukaszKautz, EwaJuszczuk- Kubiak, EdytaFerreira-Dias, GraçaDomino, Małgorzata2022-08-31T09:19:36Z2022-062022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/25304engJasiński T, Zdrojkowski Ł, Kautz E, Juszczuk- Kubiak E, Ferreira-Dias G, Domino M. 2022. The NF- κB- signalling pathway in mare's endometrium infiltrated with the inflammatory cells. Reproduction in Domestic Animals, 57(6):598–610. DOI: https://doi.org/10.1111/rda.140990936-6768https://doi.org/10.1111/rda.140991439-0531info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:54:47Zoai:www.repository.utl.pt:10400.5/25304Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:09:07.078003Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
title The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
spellingShingle The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
Jasiński, Tomasz
Endometritis
HAS
IL-6
Mare
MCP-1
NF-kappa B
title_short The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
title_full The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
title_fullStr The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
title_full_unstemmed The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
title_sort The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
author Jasiński, Tomasz
author_facet Jasiński, Tomasz
Zdrojkowski, Łukasz
Kautz, Ewa
Juszczuk- Kubiak, Edyta
Ferreira-Dias, Graça
Domino, Małgorzata
author_role author
author2 Zdrojkowski, Łukasz
Kautz, Ewa
Juszczuk- Kubiak, Edyta
Ferreira-Dias, Graça
Domino, Małgorzata
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Jasiński, Tomasz
Zdrojkowski, Łukasz
Kautz, Ewa
Juszczuk- Kubiak, Edyta
Ferreira-Dias, Graça
Domino, Małgorzata
dc.subject.por.fl_str_mv Endometritis
HAS
IL-6
Mare
MCP-1
NF-kappa B
topic Endometritis
HAS
IL-6
Mare
MCP-1
NF-kappa B
description Research Areas: Agriculture ; Reproductive Biology ; Veterinary Sciences
publishDate 2022
dc.date.none.fl_str_mv 2022-08-31T09:19:36Z
2022-06
2022-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/25304
url http://hdl.handle.net/10400.5/25304
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jasiński T, Zdrojkowski Ł, Kautz E, Juszczuk- Kubiak E, Ferreira-Dias G, Domino M. 2022. The NF- κB- signalling pathway in mare's endometrium infiltrated with the inflammatory cells. Reproduction in Domestic Animals, 57(6):598–610. DOI: https://doi.org/10.1111/rda.14099
0936-6768
https://doi.org/10.1111/rda.14099
1439-0531
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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