The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/25304 |
Resumo: | Research Areas: Agriculture ; Reproductive Biology ; Veterinary Sciences |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cellsEndometritisHASIL-6MareMCP-1NF-kappa BResearch Areas: Agriculture ; Reproductive Biology ; Veterinary SciencesABSTRACT: Endometritis is an important issue decreasing mares' fertility. In the case of endo-metritis, both inflammatory cells infiltration and proinflammatory molecules produc-tion are regulated by various cellular and gene regulatory mechanisms, including the nuclear factor- κB (NF- κB)- dependent pathway. NF- κB- signalling pathway has been recently studied in the equine endometrium in the context of endometrosis. Thus, this study aimed to determine gene transcription of NF- κB subunits (RelA; NF- κB1; NF- κB2), proinflammatory molecules (M C P - 1 ; I L- 6) and hyaluronan synthases (HAS 1; HAS 2; HAS 3) in endometritis and compare them with the intensity and type of inflamma-tory cell infiltration. Endometrial samples, collected post- mortem from cyclic mares in oestrus or dioestrus, were classified histologically and examined using quantitative PCR. Transcription NF- κB subunits genes did not differ with either inflammatory in-tensity or type of inflammatory cell infiltration. Transcription of M C P - 1 and I L- 6 genes increased with the severity of inflammation, with the involvement of HAS 3 and HAS 2 genes, as opposed to HAS 1 genes. These proinflammatory molecules and hyaluronan synthases in the equine inflamed endometrium do not seem to be regulated by the NF- κB pathway. Hence, separate signalling pathways for the development and pro-gression of equine endometritis and endometrosis may be suggestedWileyRepositório da Universidade de LisboaJasiński, TomaszZdrojkowski, ŁukaszKautz, EwaJuszczuk- Kubiak, EdytaFerreira-Dias, GraçaDomino, Małgorzata2022-08-31T09:19:36Z2022-062022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/25304engJasiński T, Zdrojkowski Ł, Kautz E, Juszczuk- Kubiak E, Ferreira-Dias G, Domino M. 2022. The NF- κB- signalling pathway in mare's endometrium infiltrated with the inflammatory cells. Reproduction in Domestic Animals, 57(6):598–610. DOI: https://doi.org/10.1111/rda.140990936-6768https://doi.org/10.1111/rda.140991439-0531info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:54:47Zoai:www.repository.utl.pt:10400.5/25304Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:09:07.078003Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells |
title |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells |
spellingShingle |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells Jasiński, Tomasz Endometritis HAS IL-6 Mare MCP-1 NF-kappa B |
title_short |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells |
title_full |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells |
title_fullStr |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells |
title_full_unstemmed |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells |
title_sort |
The NF-kappa B-signalling pathway in mare's endometrium infiltrated with the inflammatory cells |
author |
Jasiński, Tomasz |
author_facet |
Jasiński, Tomasz Zdrojkowski, Łukasz Kautz, Ewa Juszczuk- Kubiak, Edyta Ferreira-Dias, Graça Domino, Małgorzata |
author_role |
author |
author2 |
Zdrojkowski, Łukasz Kautz, Ewa Juszczuk- Kubiak, Edyta Ferreira-Dias, Graça Domino, Małgorzata |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Jasiński, Tomasz Zdrojkowski, Łukasz Kautz, Ewa Juszczuk- Kubiak, Edyta Ferreira-Dias, Graça Domino, Małgorzata |
dc.subject.por.fl_str_mv |
Endometritis HAS IL-6 Mare MCP-1 NF-kappa B |
topic |
Endometritis HAS IL-6 Mare MCP-1 NF-kappa B |
description |
Research Areas: Agriculture ; Reproductive Biology ; Veterinary Sciences |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-31T09:19:36Z 2022-06 2022-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/25304 |
url |
http://hdl.handle.net/10400.5/25304 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Jasiński T, Zdrojkowski Ł, Kautz E, Juszczuk- Kubiak E, Ferreira-Dias G, Domino M. 2022. The NF- κB- signalling pathway in mare's endometrium infiltrated with the inflammatory cells. Reproduction in Domestic Animals, 57(6):598–610. DOI: https://doi.org/10.1111/rda.14099 0936-6768 https://doi.org/10.1111/rda.14099 1439-0531 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799131185819942912 |