Population structure of a vector of human diseases
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/116887 |
Resumo: | Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt thatthe ancestral home of the species is Africa. This mosquito invaded the New World400-500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of theNew World invasion. Here, we use ∼17,000 genome-wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of thismosquito across its ancestral range in Africa. We find signatures of human-assistedmigrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogeneticanalysis combined with the genetic structure analyses, we suggest West Africa andespecially Angola as the source of the New World's invasion, a scenario that fits wellwith the historic record of 16th-century slave trade between Africa and Americas. |
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Population structure of a vector of human diseasesAedes aegypti in its ancestral range, AfricaAedes aegyptiAfricaGeneticsMigrationPopulation structureSNP-chipGeneticsEcology, Evolution, Behavior and SystematicsInsect ScienceInfectious DiseasesSDG 3 - Good Health and Well-beingSDG 15 - Life on LandAedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt thatthe ancestral home of the species is Africa. This mosquito invaded the New World400-500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of theNew World invasion. Here, we use ∼17,000 genome-wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of thismosquito across its ancestral range in Africa. We find signatures of human-assistedmigrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogeneticanalysis combined with the genetic structure analyses, we suggest West Africa andespecially Angola as the source of the New World's invasion, a scenario that fits wellwith the historic record of 16th-century slave trade between Africa and Americas.Vector borne diseases and pathogens (VBD)Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)RUNKotsakiozi, PanayiotaEvans, Benjamin R.Gloria-Soria, AndreaKamgang, BasileMayanja, MartinLutwama, JuliusLe Goff, GilbertAyala, DiegoPaupy, ChristopheBadolo, AthanasePinto, JoaoSousa, Carla A.Troco, Arlete D.Powell, Jeffrey R.2021-05-03T22:53:16Z2018-01-012018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/116887eng1751-0252PURE: 20086696https://doi.org/10.1002/ece3.4278info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:44Zoai:run.unl.pt:10362/116887Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:21.014938Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Population structure of a vector of human diseases Aedes aegypti in its ancestral range, Africa |
title |
Population structure of a vector of human diseases |
spellingShingle |
Population structure of a vector of human diseases Kotsakiozi, Panayiota Aedes aegypti Africa Genetics Migration Population structure SNP-chip Genetics Ecology, Evolution, Behavior and Systematics Insect Science Infectious Diseases SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
title_short |
Population structure of a vector of human diseases |
title_full |
Population structure of a vector of human diseases |
title_fullStr |
Population structure of a vector of human diseases |
title_full_unstemmed |
Population structure of a vector of human diseases |
title_sort |
Population structure of a vector of human diseases |
author |
Kotsakiozi, Panayiota |
author_facet |
Kotsakiozi, Panayiota Evans, Benjamin R. Gloria-Soria, Andrea Kamgang, Basile Mayanja, Martin Lutwama, Julius Le Goff, Gilbert Ayala, Diego Paupy, Christophe Badolo, Athanase Pinto, Joao Sousa, Carla A. Troco, Arlete D. Powell, Jeffrey R. |
author_role |
author |
author2 |
Evans, Benjamin R. Gloria-Soria, Andrea Kamgang, Basile Mayanja, Martin Lutwama, Julius Le Goff, Gilbert Ayala, Diego Paupy, Christophe Badolo, Athanase Pinto, Joao Sousa, Carla A. Troco, Arlete D. Powell, Jeffrey R. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Vector borne diseases and pathogens (VBD) Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) RUN |
dc.contributor.author.fl_str_mv |
Kotsakiozi, Panayiota Evans, Benjamin R. Gloria-Soria, Andrea Kamgang, Basile Mayanja, Martin Lutwama, Julius Le Goff, Gilbert Ayala, Diego Paupy, Christophe Badolo, Athanase Pinto, Joao Sousa, Carla A. Troco, Arlete D. Powell, Jeffrey R. |
dc.subject.por.fl_str_mv |
Aedes aegypti Africa Genetics Migration Population structure SNP-chip Genetics Ecology, Evolution, Behavior and Systematics Insect Science Infectious Diseases SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
topic |
Aedes aegypti Africa Genetics Migration Population structure SNP-chip Genetics Ecology, Evolution, Behavior and Systematics Insect Science Infectious Diseases SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
description |
Aedes aegypti, the major vector of dengue, yellow fever, chikungunya, and Zika viruses, remains of great medical and public health concern. There is little doubt thatthe ancestral home of the species is Africa. This mosquito invaded the New World400-500 years ago and later, Asia. However, little is known about the genetic structure and history of Ae. aegypti across Africa, as well as the possible origin(s) of theNew World invasion. Here, we use ∼17,000 genome-wide single nucleotide polymorphisms (SNPs) to characterize a heretofore undocumented complex picture of thismosquito across its ancestral range in Africa. We find signatures of human-assistedmigrations, connectivity across long distances in sylvan populations, and of local admixture between domestic and sylvan populations. Finally, through a phylogeneticanalysis combined with the genetic structure analyses, we suggest West Africa andespecially Angola as the source of the New World's invasion, a scenario that fits wellwith the historic record of 16th-century slave trade between Africa and Americas. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 2018-01-01T00:00:00Z 2021-05-03T22:53:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/116887 |
url |
http://hdl.handle.net/10362/116887 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1751-0252 PURE: 20086696 https://doi.org/10.1002/ece3.4278 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
14 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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