Caffeine, adenosine receptors, and synaptic plasticity

Detalhes bibliográficos
Autor(a) principal: Costenla, Ana Rita
Data de Publicação: 2010
Outros Autores: Cunha, Rodrigo A., De Mendonça, Alexandre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/6253
Resumo: Copyright ©2012 IOS Press All rights reserved.
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spelling Caffeine, adenosine receptors, and synaptic plasticityA2A receptorsAdenosineCaffeineLong-term potentiationHippocampusSynaptic plasticityCopyright ©2012 IOS Press All rights reserved.Few studies to date have looked at the effects of caffeine on synaptic plasticity, and those that did used very high concentrations of caffeine, whereas the brain concentrations attained by regular coffee consumption in humans should be in the low micromolar range, where caffeine exerts pharmacological actions mainly by antagonizing adenosine receptors. Accordingly, rats drinking caffeine (1 g/L) for 3 weeks, displayed a concentration of caffeine of circa 22 μM in the hippocampus. It is known that selective adenosine A1 receptor antagonists facilitate, whereas selective adenosine A2A receptor antagonists attenuate, long term potentiation (LTP) in the hippocampus. Although caffeine is a non-selective antagonist of adenosine receptors, it attenuates frequency-induced LTP in hippocampal slices in a manner similar to selective adenosine A2A receptor antagonists. These effects of low micromolar concentration of caffeine (30 μM) are maintained in aged animals, which is important when a possible beneficial effect for caffeine in age-related cognitive decline is proposed. Future studies will still be required to confirm and detail the involvement of A1 and A2A receptors in the effects of caffeine on hippocampal synaptic plasticity, using both pharmacological and genetic approaches.The work was supported by Fundação para a Ciência e Tecnologia and Fundação Oriente.IOS PressRepositório da Universidade de LisboaCostenla, Ana RitaCunha, Rodrigo A.De Mendonça, Alexandre2012-05-09T13:23:15Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/6253engJournal of Alzheimer’s Disease 20 (2010) S25–S341387-2877info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:48:39Zoai:repositorio.ul.pt:10451/6253Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:31:25.660390Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Caffeine, adenosine receptors, and synaptic plasticity
title Caffeine, adenosine receptors, and synaptic plasticity
spellingShingle Caffeine, adenosine receptors, and synaptic plasticity
Costenla, Ana Rita
A2A receptors
Adenosine
Caffeine
Long-term potentiation
Hippocampus
Synaptic plasticity
title_short Caffeine, adenosine receptors, and synaptic plasticity
title_full Caffeine, adenosine receptors, and synaptic plasticity
title_fullStr Caffeine, adenosine receptors, and synaptic plasticity
title_full_unstemmed Caffeine, adenosine receptors, and synaptic plasticity
title_sort Caffeine, adenosine receptors, and synaptic plasticity
author Costenla, Ana Rita
author_facet Costenla, Ana Rita
Cunha, Rodrigo A.
De Mendonça, Alexandre
author_role author
author2 Cunha, Rodrigo A.
De Mendonça, Alexandre
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Costenla, Ana Rita
Cunha, Rodrigo A.
De Mendonça, Alexandre
dc.subject.por.fl_str_mv A2A receptors
Adenosine
Caffeine
Long-term potentiation
Hippocampus
Synaptic plasticity
topic A2A receptors
Adenosine
Caffeine
Long-term potentiation
Hippocampus
Synaptic plasticity
description Copyright ©2012 IOS Press All rights reserved.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2012-05-09T13:23:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/6253
url http://hdl.handle.net/10451/6253
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Alzheimer’s Disease 20 (2010) S25–S34
1387-2877
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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