Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice

Detalhes bibliográficos
Autor(a) principal: Fontinha, Bruno M
Data de Publicação: 2009
Outros Autores: Delgado-García, José M, Madroñal, Noelia, Ribeiro, Joaquim A, Sebastião, Ana M, Gruart, Agnès
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/6731
Resumo: © 2009 Nature Publishing Group All rights reserved
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spelling Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving miceAdenosine A2A receptorCA3-CA1 synapseClassical conditioningHippocampusMiceLong-term potentiation© 2009 Nature Publishing Group All rights reservedPrevious in vitro studies have characterized the electrophysiological and molecular signaling pathways of adenosine tonic modulation on long-lasting synaptic plasticity events, particularly for hippocampal long-term potentiation(LTP). However, it remains to be elucidated whether the long-term changes produced by endogenous adenosine in the efficiency of synapses are related to those required for learning and memory formation. Our goal was to understand how endogenous activation of adenosine excitatory A2A receptors modulates the associative learning evolution in conscious behaving mice. We have studied here the effects of the application of a highly selective A2A receptor antagonist, SCH58261, upon a well-known associative learning paradigm - classical eyeblink conditioning. We used a trace paradigm, with a tone as the conditioned stimulus (CS) and an electric shock presented to the supraorbital nerve as the unconditioned stimulus(US). A single electrical pulse was presented to the Schaffer collateral–commissural pathway to evoke field EPSPs (fEPSPs) in the pyramidal CA1 area during the CS–US interval. In vehicle-injected animals, there was a progressive increase in the percentage of conditioning responses (CRs) and in the slope of fEPSPs through conditioning sessions, an effect that was completely prevented (and lost) in SCH58261 (0.5 mg/kg, i.p.)-injected animals. Moreover, experimentally evoked LTP was impaired in SCH58261- injected mice. In conclusion, the endogenous activation of adenosine A2A receptors plays a pivotal effect on the associative learning process and its relevant hippocampal circuits, including activity-dependent changes at the CA3-CA1 synapse.This study was supported by grants from the Spanish Ministry of Education and Research (BFU2005-01024 and BFU2005-02512), Spanish Junta de Andalucía (BIO-122 and CVI-02487), and the Fundación Conocimiento y Cultura of the Pablo de Olavide University (Seville, Spain).B. Fontinha was in receipt of a studentship from a project grant (POCI/SAU-NEU/56332/2004) supported by Fundação para a Ciência e Tecnologia (FCT, Portugal), and of an STSM from Cost B30 concerted action of the EU.Nature Publishing GroupRepositório da Universidade de LisboaFontinha, Bruno MDelgado-García, José MMadroñal, NoeliaRibeiro, Joaquim ASebastião, Ana MGruart, Agnès2012-07-23T09:54:02Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10451/6731engNeuropsychopharmacology (2009), 1–100893-133Xhttp://dx.doi.org/10.1038/npp.2009.8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T17:09:18Zoai:repositorio.ul.pt:10451/6731Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T17:09:18Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
title Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
spellingShingle Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
Fontinha, Bruno M
Adenosine A2A receptor
CA3-CA1 synapse
Classical conditioning
Hippocampus
Mice
Long-term potentiation
title_short Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
title_full Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
title_fullStr Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
title_full_unstemmed Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
title_sort Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
author Fontinha, Bruno M
author_facet Fontinha, Bruno M
Delgado-García, José M
Madroñal, Noelia
Ribeiro, Joaquim A
Sebastião, Ana M
Gruart, Agnès
author_role author
author2 Delgado-García, José M
Madroñal, Noelia
Ribeiro, Joaquim A
Sebastião, Ana M
Gruart, Agnès
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Fontinha, Bruno M
Delgado-García, José M
Madroñal, Noelia
Ribeiro, Joaquim A
Sebastião, Ana M
Gruart, Agnès
dc.subject.por.fl_str_mv Adenosine A2A receptor
CA3-CA1 synapse
Classical conditioning
Hippocampus
Mice
Long-term potentiation
topic Adenosine A2A receptor
CA3-CA1 synapse
Classical conditioning
Hippocampus
Mice
Long-term potentiation
description © 2009 Nature Publishing Group All rights reserved
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2012-07-23T09:54:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/6731
url http://hdl.handle.net/10451/6731
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neuropsychopharmacology (2009), 1–10
0893-133X
http://dx.doi.org/10.1038/npp.2009.8
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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