Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity

Detalhes bibliográficos
Autor(a) principal: Lopes, Noëlla
Data de Publicação: 2020
Outros Autores: Silva-Santos, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47212
Resumo: © 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License.
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spelling Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunityIFN-γIL-17MetabolismTumor immunologyγδ T cells© 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License.γδ T cells can display a plethora of immune functions, but recent studies have highlighted their importance, in multiple disease models, as sources of the pro-inflammatory cytokines, IL-17A (IL-17), and IFN-γ. These are produced by distinct murine effector γδ T cell subsets that diverge during thymic γδ T cell development. Among the multiple roles these subsets play in peripheral tissues, a striking dichotomy has emerged at tumor sites: whereas IFN-γ+ γδ T cells inhibit tumor cell growth, IL-17+ γδ T cells promote tumor progression and metastasis formation. In this review, we discuss the main lines of evidence, mostly from preclinical studies in mouse models, for this functional dichotomy in cancer immunity. We further highlight very recent advances in our understanding how metabolic sources and pathways can impact on the balance between IFN-γ+ and IL-17+ γδ T cells in the tumor microenvironment, which opens a new exciting avenue to explore toward the application of γδ T cells in cancer immunotherapy.Our work is supported by “la Caixa” Foundation’s Health Research Program, project HR18-00069; PAC-PRECISE LISBOA-01-0145-FEDER-016394, co-funded by FEDER (POR Lisboa 2020) and Fundação para a Ciência e a Tecnologia (Portugal); and N.L. received an EMBO long term fellowship (ALTF 752–2018).John Wiley & Sons, Inc.Repositório da Universidade de LisboaLopes, NoëllaSilva-Santos, Bruno2021-04-01T16:07:01Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47212engEur. J. Immunol. 2021. 51: 17–260014-298010.1002/eji.2019484021521-4141info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:57Zoai:repositorio.ul.pt:10451/47212Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:17.294628Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
title Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
spellingShingle Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
Lopes, Noëlla
IFN-γ
IL-17
Metabolism
Tumor immunology
γδ T cells
title_short Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
title_full Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
title_fullStr Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
title_full_unstemmed Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
title_sort Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
author Lopes, Noëlla
author_facet Lopes, Noëlla
Silva-Santos, Bruno
author_role author
author2 Silva-Santos, Bruno
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Lopes, Noëlla
Silva-Santos, Bruno
dc.subject.por.fl_str_mv IFN-γ
IL-17
Metabolism
Tumor immunology
γδ T cells
topic IFN-γ
IL-17
Metabolism
Tumor immunology
γδ T cells
description © 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-04-01T16:07:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47212
url http://hdl.handle.net/10451/47212
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur. J. Immunol. 2021. 51: 17–26
0014-2980
10.1002/eji.201948402
1521-4141
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons, Inc.
publisher.none.fl_str_mv John Wiley & Sons, Inc.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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