B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2002 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12892 |
Resumo: | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil |
| id |
CRUZ_2a9d406db040f1b9e443a0ab13bae2f0 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/12892 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Vieira, Maria das Graças SilvaOliveira, Luis Fabiano BorgesArruda, Sérgio MarcosBittencourt, Achilea Candida LisboaBarbosa Junior, Aryon de AlmeidaBarral Netto, ManoelBarral, Aldina Maria Prado2016-02-29T13:21:40Z2016-02-29T13:21:40Z2002VIEIRA, M. G. S. et al. B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases. Memórias do Instituto Oswaldo Cruz, v. 97, n. 7, p. 979-983, 2002.0074-0276https://www.arca.fiocruz.br/handle/icict/12892engInstituto Oswaldo CruzB-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital Professor Edgard Santos. Serviço de Anatomia Patológica. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital Professor Edgard Santos. Serviço de Anatomia Patológica. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / ***Instituto de Investigação em Imunologia, Instituto do Milênio, São Paulo, SP, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / ***Instituto de Investigação em Imunologia, Instituto do Milênio, São Paulo, SP, BrasilBiopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration, frequency of cytokine (IFN-g, TNF-a) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN- g expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-a and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-g producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ.LeishmaniasisB lymphocytesCytokinesCD8+ T cellsIFN-ginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12892/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVieira M G B-cell infiltration....pdfVieira M G B-cell infiltration....pdfapplication/pdf57883https://www.arca.fiocruz.br/bitstream/icict/12892/2/Vieira%20M%20G%20B-cell%20infiltration....pdfdcb00a38cbd96d2a01cb584028725a4cMD52TEXTVieira M G B-cell infiltration....pdf.txtVieira M G B-cell infiltration....pdf.txtExtracted texttext/plain25538https://www.arca.fiocruz.br/bitstream/icict/12892/3/Vieira%20M%20G%20B-cell%20infiltration....pdf.txtdceacab3fb30918b8424f0dd602a21efMD53icict/128922023-03-15 14:34:02.398oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases |
| title |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases |
| spellingShingle |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases Vieira, Maria das Graças Silva Leishmaniasis B lymphocytes Cytokines CD8+ T cells IFN-g |
| title_short |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases |
| title_full |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases |
| title_fullStr |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases |
| title_full_unstemmed |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases |
| title_sort |
B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases |
| author |
Vieira, Maria das Graças Silva |
| author_facet |
Vieira, Maria das Graças Silva Oliveira, Luis Fabiano Borges Arruda, Sérgio Marcos Bittencourt, Achilea Candida Lisboa Barbosa Junior, Aryon de Almeida Barral Netto, Manoel Barral, Aldina Maria Prado |
| author_role |
author |
| author2 |
Oliveira, Luis Fabiano Borges Arruda, Sérgio Marcos Bittencourt, Achilea Candida Lisboa Barbosa Junior, Aryon de Almeida Barral Netto, Manoel Barral, Aldina Maria Prado |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Vieira, Maria das Graças Silva Oliveira, Luis Fabiano Borges Arruda, Sérgio Marcos Bittencourt, Achilea Candida Lisboa Barbosa Junior, Aryon de Almeida Barral Netto, Manoel Barral, Aldina Maria Prado |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis B lymphocytes Cytokines CD8+ T cells IFN-g |
| topic |
Leishmaniasis B lymphocytes Cytokines CD8+ T cells IFN-g |
| description |
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil |
| publishDate |
2002 |
| dc.date.issued.fl_str_mv |
2002 |
| dc.date.accessioned.fl_str_mv |
2016-02-29T13:21:40Z |
| dc.date.available.fl_str_mv |
2016-02-29T13:21:40Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
VIEIRA, M. G. S. et al. B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases. Memórias do Instituto Oswaldo Cruz, v. 97, n. 7, p. 979-983, 2002. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/12892 |
| dc.identifier.issn.none.fl_str_mv |
0074-0276 |
| identifier_str_mv |
VIEIRA, M. G. S. et al. B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases. Memórias do Instituto Oswaldo Cruz, v. 97, n. 7, p. 979-983, 2002. 0074-0276 |
| url |
https://www.arca.fiocruz.br/handle/icict/12892 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz |
| publisher.none.fl_str_mv |
Instituto Oswaldo Cruz |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/12892/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/12892/2/Vieira%20M%20G%20B-cell%20infiltration....pdf https://www.arca.fiocruz.br/bitstream/icict/12892/3/Vieira%20M%20G%20B-cell%20infiltration....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 dcb00a38cbd96d2a01cb584028725a4c dceacab3fb30918b8424f0dd602a21ef |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324829312516096 |