A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/30940 https://doi.org/10.1177/00236772211035250 |
Resumo: | Oral administration of medication to experimental animals is a cause of significant stress. When coupled to animals who are already under strenuous circumstances due to the disease being modelled, there is a significant risk for increased morbidity and mortality, thus influencing the results. Faced with these con- straints, a low-intensity method for oral administration was developed, based solely on the natural behaviour of the animals and minimal conditioning, in which precise doses of medication were administered in a locally available, standard wheat cookie fragment, providing both a palatable vehicle and an absorbent matrix for the medication. Fast administration to large numbers of animals was thus achieved, safeguarding the animals’ welfare and ensuring ease of handling. This method is a promising alternative to oral gavage in pre-clinical drug studies with laboratory mice. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavagecookiefastmousestressoral administrationoral gavagewelfareOral administration of medication to experimental animals is a cause of significant stress. When coupled to animals who are already under strenuous circumstances due to the disease being modelled, there is a significant risk for increased morbidity and mortality, thus influencing the results. Faced with these con- straints, a low-intensity method for oral administration was developed, based solely on the natural behaviour of the animals and minimal conditioning, in which precise doses of medication were administered in a locally available, standard wheat cookie fragment, providing both a palatable vehicle and an absorbent matrix for the medication. Fast administration to large numbers of animals was thus achieved, safeguarding the animals’ welfare and ensuring ease of handling. This method is a promising alternative to oral gavage in pre-clinical drug studies with laboratory mice.Laboratory Animals2022-01-31T15:22:43Z2022-01-312021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/30940https://doi.org/10.1177/00236772211035250http://hdl.handle.net/10174/30940https://doi.org/10.1177/00236772211035250engNeto T, Faustino-Rocha AI, Gil da Costa RM, Medeiros R, Oliveira PA. 2021. A quick and low-intensity method for oral administration to large numbers of mice: a possible alternative to oral gavage. Laboratory Animals 0(0): 1-6.1-600ndanafaustino@uevora.ptndndnd206Neto, TiagoFaustino-Rocha, Ana IsabelGil da Costa, Rui MiguelMedeiros, RuiOliveira, Paula Alexandrainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:27:39Zoai:dspace.uevora.pt:10174/30940Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:19:35.131804Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage |
title |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage |
spellingShingle |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage Neto, Tiago cookie fast mouse stress oral administration oral gavage welfare |
title_short |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage |
title_full |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage |
title_fullStr |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage |
title_full_unstemmed |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage |
title_sort |
A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage |
author |
Neto, Tiago |
author_facet |
Neto, Tiago Faustino-Rocha, Ana Isabel Gil da Costa, Rui Miguel Medeiros, Rui Oliveira, Paula Alexandra |
author_role |
author |
author2 |
Faustino-Rocha, Ana Isabel Gil da Costa, Rui Miguel Medeiros, Rui Oliveira, Paula Alexandra |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Neto, Tiago Faustino-Rocha, Ana Isabel Gil da Costa, Rui Miguel Medeiros, Rui Oliveira, Paula Alexandra |
dc.subject.por.fl_str_mv |
cookie fast mouse stress oral administration oral gavage welfare |
topic |
cookie fast mouse stress oral administration oral gavage welfare |
description |
Oral administration of medication to experimental animals is a cause of significant stress. When coupled to animals who are already under strenuous circumstances due to the disease being modelled, there is a significant risk for increased morbidity and mortality, thus influencing the results. Faced with these con- straints, a low-intensity method for oral administration was developed, based solely on the natural behaviour of the animals and minimal conditioning, in which precise doses of medication were administered in a locally available, standard wheat cookie fragment, providing both a palatable vehicle and an absorbent matrix for the medication. Fast administration to large numbers of animals was thus achieved, safeguarding the animals’ welfare and ensuring ease of handling. This method is a promising alternative to oral gavage in pre-clinical drug studies with laboratory mice. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01T00:00:00Z 2022-01-31T15:22:43Z 2022-01-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/30940 https://doi.org/10.1177/00236772211035250 http://hdl.handle.net/10174/30940 https://doi.org/10.1177/00236772211035250 |
url |
http://hdl.handle.net/10174/30940 https://doi.org/10.1177/00236772211035250 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neto T, Faustino-Rocha AI, Gil da Costa RM, Medeiros R, Oliveira PA. 2021. A quick and low-intensity method for oral administration to large numbers of mice: a possible alternative to oral gavage. Laboratory Animals 0(0): 1-6. 1-6 0 0 nd anafaustino@uevora.pt nd nd nd 206 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Laboratory Animals |
publisher.none.fl_str_mv |
Laboratory Animals |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799136677120180224 |