Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation

Detalhes bibliográficos
Autor(a) principal: Fernandes, Maria A. S.
Data de Publicação: 2000
Outros Autores: Geraldes, Carlos F. G. C., Oliveira, Catarina R., Alpoim, Maria C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5443
https://doi.org/10.1006/eesa.1999.1939
Resumo: The effects of NADH and H2O2 on chromate-induced human erythrocyte hemoglobin oxidation and peroxidation were studied. It was observed that NADH decreases the levels of chromate-induced human erythrocyte hemoglobin oxidation and peroxidation. H2O2 decreases the levels of chromate-induced hemoglobin oxidation, but increases the levels of chromate-induced peroxidation. The ability of H2O2 to decrease the levels of chromate-induced hemoglobin oxidation is higher than that observed for NADH. Furthermore, H2O2 increases the inhibitory effect of NADH on chromate-induced hemoglobin oxidation, but decreases the NADH effect on chromate-induced peroxidation. The meaning of these results is discussed in terms of involvement of reactive chromium(V) species and reactive oxygen species in the mechanism by which chromate induces its effects in human erythrocytes.
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spelling Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidationchromate; human erythrocytes; hemoglobin oxidation; H2O2; NADH; peroxidation.The effects of NADH and H2O2 on chromate-induced human erythrocyte hemoglobin oxidation and peroxidation were studied. It was observed that NADH decreases the levels of chromate-induced human erythrocyte hemoglobin oxidation and peroxidation. H2O2 decreases the levels of chromate-induced hemoglobin oxidation, but increases the levels of chromate-induced peroxidation. The ability of H2O2 to decrease the levels of chromate-induced hemoglobin oxidation is higher than that observed for NADH. Furthermore, H2O2 increases the inhibitory effect of NADH on chromate-induced hemoglobin oxidation, but decreases the NADH effect on chromate-induced peroxidation. The meaning of these results is discussed in terms of involvement of reactive chromium(V) species and reactive oxygen species in the mechanism by which chromate induces its effects in human erythrocytes.http://www.sciencedirect.com/science/article/B6WDM-45F555T-18/1/46aa99392835526515f01bd943044fb32000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5443http://hdl.handle.net/10316/5443https://doi.org/10.1006/eesa.1999.1939engEcotoxicology and Environmental Safety. 47:1 (2000) 39-42Fernandes, Maria A. S.Geraldes, Carlos F. G. C.Oliveira, Catarina R.Alpoim, Maria C.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:48:38Zoai:estudogeral.uc.pt:10316/5443Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:55:30.146613Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
title Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
spellingShingle Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
Fernandes, Maria A. S.
chromate; human erythrocytes; hemoglobin oxidation; H2O2; NADH; peroxidation.
title_short Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
title_full Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
title_fullStr Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
title_full_unstemmed Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
title_sort Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxidation and Peroxidation
author Fernandes, Maria A. S.
author_facet Fernandes, Maria A. S.
Geraldes, Carlos F. G. C.
Oliveira, Catarina R.
Alpoim, Maria C.
author_role author
author2 Geraldes, Carlos F. G. C.
Oliveira, Catarina R.
Alpoim, Maria C.
author2_role author
author
author
dc.contributor.author.fl_str_mv Fernandes, Maria A. S.
Geraldes, Carlos F. G. C.
Oliveira, Catarina R.
Alpoim, Maria C.
dc.subject.por.fl_str_mv chromate; human erythrocytes; hemoglobin oxidation; H2O2; NADH; peroxidation.
topic chromate; human erythrocytes; hemoglobin oxidation; H2O2; NADH; peroxidation.
description The effects of NADH and H2O2 on chromate-induced human erythrocyte hemoglobin oxidation and peroxidation were studied. It was observed that NADH decreases the levels of chromate-induced human erythrocyte hemoglobin oxidation and peroxidation. H2O2 decreases the levels of chromate-induced hemoglobin oxidation, but increases the levels of chromate-induced peroxidation. The ability of H2O2 to decrease the levels of chromate-induced hemoglobin oxidation is higher than that observed for NADH. Furthermore, H2O2 increases the inhibitory effect of NADH on chromate-induced hemoglobin oxidation, but decreases the NADH effect on chromate-induced peroxidation. The meaning of these results is discussed in terms of involvement of reactive chromium(V) species and reactive oxygen species in the mechanism by which chromate induces its effects in human erythrocytes.
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5443
http://hdl.handle.net/10316/5443
https://doi.org/10.1006/eesa.1999.1939
url http://hdl.handle.net/10316/5443
https://doi.org/10.1006/eesa.1999.1939
dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv Ecotoxicology and Environmental Safety. 47:1 (2000) 39-42
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