Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins

Detalhes bibliográficos
Autor(a) principal: Dias, Maria Inês
Data de Publicação: 2014
Outros Autores: Barreira, João C. M., Calhelha, Ricardo C., Queiroz, Maria João R. P., Oliveira, M. Beatriz P. P., Soković, Marina, Ferreira, Isabel C. F. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/63908
Resumo: "Article ID 520464"
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spelling Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different originsAnti-Infective AgentsAntineoplastic AgentsBacteriaCell Line, TumorDrug Screening Assays, AntitumorFungiHumansLaurusMethanolMicrobial Sensitivity TestsPhenolsPlant ExtractsPrincipal Component AnalysisScience & Technology"Article ID 520464"Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts. Specifically, methanol and aqueous extracts of wild and cultivated samples of L. nobilis were compared considering different phenolic groups. Principal component analysis (PCA) was applied to understand how each extract acts differentially against specific bacteria, fungi, and selected human tumor cell lines. In general, the extract type induced the highest differences in bioactivity of laurel samples. However, from the PCA biplot, it became clear that wild laurel samples were higher inhibitors of tumor cell lines (HeLa, MCF7, NCI-H460, and HCT15). HepG2 had the same response to laurel from wild and cultivated origin. It was also observed that methanolic extracts tended to have higher antimicrobial activity, except against A. niger, A. fumigatus, and P. verrucosum. The differences in bioactivity might be related to the higher phenolic contents in methanolic extracts. These results allow selecting the extract type and/or origin with highest antibacterial, antifungal, and antitumor activity.The authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for the financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011) and REQUIMTE (PEst-C/EQB/LA0006/2011). M. I. Dias, R. Calhelha, and J. C. M. Barreira also thank FCT, POPHQREN, and FSE for their Grants (SFRH/BD/84485/2012, SFRH/BPD/ 68344/2010, and BPD/72802/2010). The authors also thank to Serbian Ministry of Education and Science for financial support (grant number 173032).Hindawi LimitedUniversidade do MinhoDias, Maria InêsBarreira, João C. M.Calhelha, Ricardo C.Queiroz, Maria João R. P.Oliveira, M. Beatriz P. P.Soković, MarinaFerreira, Isabel C. F. R.20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/63908eng2314-61332314-614110.1155/2014/52046424826380info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:27:42Zoai:repositorium.sdum.uminho.pt:1822/63908Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:22:22.040081Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
title Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
spellingShingle Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
Dias, Maria Inês
Anti-Infective Agents
Antineoplastic Agents
Bacteria
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fungi
Humans
Laurus
Methanol
Microbial Sensitivity Tests
Phenols
Plant Extracts
Principal Component Analysis
Science & Technology
title_short Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
title_full Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
title_fullStr Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
title_full_unstemmed Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
title_sort Two-dimensional PCA highlights the differentiated antitumor and antimicrobial activity of methanolic and aqueous extracts of Laurus nobilis L. from different origins
author Dias, Maria Inês
author_facet Dias, Maria Inês
Barreira, João C. M.
Calhelha, Ricardo C.
Queiroz, Maria João R. P.
Oliveira, M. Beatriz P. P.
Soković, Marina
Ferreira, Isabel C. F. R.
author_role author
author2 Barreira, João C. M.
Calhelha, Ricardo C.
Queiroz, Maria João R. P.
Oliveira, M. Beatriz P. P.
Soković, Marina
Ferreira, Isabel C. F. R.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Dias, Maria Inês
Barreira, João C. M.
Calhelha, Ricardo C.
Queiroz, Maria João R. P.
Oliveira, M. Beatriz P. P.
Soković, Marina
Ferreira, Isabel C. F. R.
dc.subject.por.fl_str_mv Anti-Infective Agents
Antineoplastic Agents
Bacteria
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fungi
Humans
Laurus
Methanol
Microbial Sensitivity Tests
Phenols
Plant Extracts
Principal Component Analysis
Science & Technology
topic Anti-Infective Agents
Antineoplastic Agents
Bacteria
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fungi
Humans
Laurus
Methanol
Microbial Sensitivity Tests
Phenols
Plant Extracts
Principal Component Analysis
Science & Technology
description "Article ID 520464"
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/63908
url http://hdl.handle.net/1822/63908
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2314-6133
2314-6141
10.1155/2014/520464
24826380
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Limited
publisher.none.fl_str_mv Hindawi Limited
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132693657550848

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