Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6

Detalhes bibliográficos
Autor(a) principal: Pereira, L
Data de Publicação: 2010
Outros Autores: Silva, NM, Franco-Duarte, R, Fernandes, V, Pereira, JB, Costa, MD, Martins, H, Soares, P, Behar, DM, Richards, MB, Macaulay, V
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/109257
Resumo: BACKGROUND: The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. RESULTS: Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. CONCLUSIONS: A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast.
id RCAP_b2c5773af10a02ebba587b94ac0b59cc
oai_identifier_str oai:repositorio-aberto.up.pt:10216/109257
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6Africa NorthernAfrican Continental Ancestry Group/geneticsBayes TheoremDNA Mitochondrial/geneticsEuropeEvolution, MolecularGenetics, PopulationGenome HumanHaplotypesHumansLikelihood FunctionsMutationPhylogenyPhylogeographySelection GeneticBACKGROUND: The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. RESULTS: Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. CONCLUSIONS: A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast.BioMed Central20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/mswordapplication/vnd.ms-excelhttp://hdl.handle.net/10216/109257eng1471-214810.1186/1471-2148-10-390Pereira, LSilva, NMFranco-Duarte, RFernandes, VPereira, JBCosta, MDMartins, HSoares, PBehar, DMRichards, MBMacaulay, Vinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:20:20Zoai:repositorio-aberto.up.pt:10216/109257Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:59:13.638992Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
title Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
spellingShingle Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
Pereira, L
Africa Northern
African Continental Ancestry Group/genetics
Bayes Theorem
DNA Mitochondrial/genetics
Europe
Evolution, Molecular
Genetics, Population
Genome Human
Haplotypes
Humans
Likelihood Functions
Mutation
Phylogeny
Phylogeography
Selection Genetic
title_short Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
title_full Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
title_fullStr Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
title_full_unstemmed Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
title_sort Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
author Pereira, L
author_facet Pereira, L
Silva, NM
Franco-Duarte, R
Fernandes, V
Pereira, JB
Costa, MD
Martins, H
Soares, P
Behar, DM
Richards, MB
Macaulay, V
author_role author
author2 Silva, NM
Franco-Duarte, R
Fernandes, V
Pereira, JB
Costa, MD
Martins, H
Soares, P
Behar, DM
Richards, MB
Macaulay, V
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira, L
Silva, NM
Franco-Duarte, R
Fernandes, V
Pereira, JB
Costa, MD
Martins, H
Soares, P
Behar, DM
Richards, MB
Macaulay, V
dc.subject.por.fl_str_mv Africa Northern
African Continental Ancestry Group/genetics
Bayes Theorem
DNA Mitochondrial/genetics
Europe
Evolution, Molecular
Genetics, Population
Genome Human
Haplotypes
Humans
Likelihood Functions
Mutation
Phylogeny
Phylogeography
Selection Genetic
topic Africa Northern
African Continental Ancestry Group/genetics
Bayes Theorem
DNA Mitochondrial/genetics
Europe
Evolution, Molecular
Genetics, Population
Genome Human
Haplotypes
Humans
Likelihood Functions
Mutation
Phylogeny
Phylogeography
Selection Genetic
description BACKGROUND: The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. RESULTS: Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. CONCLUSIONS: A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/109257
url http://hdl.handle.net/10216/109257
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1471-2148
10.1186/1471-2148-10-390
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/msword
application/vnd.ms-excel
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799135915973541889