Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10216/109257 |
Resumo: | BACKGROUND: The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. RESULTS: Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. CONCLUSIONS: A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
spelling |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6Africa NorthernAfrican Continental Ancestry Group/geneticsBayes TheoremDNA Mitochondrial/geneticsEuropeEvolution, MolecularGenetics, PopulationGenome HumanHaplotypesHumansLikelihood FunctionsMutationPhylogenyPhylogeographySelection GeneticBACKGROUND: The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. RESULTS: Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. CONCLUSIONS: A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast.BioMed Central20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/mswordapplication/vnd.ms-excelhttp://hdl.handle.net/10216/109257eng1471-214810.1186/1471-2148-10-390Pereira, LSilva, NMFranco-Duarte, RFernandes, VPereira, JBCosta, MDMartins, HSoares, PBehar, DMRichards, MBMacaulay, Vinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:20:20Zoai:repositorio-aberto.up.pt:10216/109257Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:59:13.638992Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 |
title |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 |
spellingShingle |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 Pereira, L Africa Northern African Continental Ancestry Group/genetics Bayes Theorem DNA Mitochondrial/genetics Europe Evolution, Molecular Genetics, Population Genome Human Haplotypes Humans Likelihood Functions Mutation Phylogeny Phylogeography Selection Genetic |
title_short |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 |
title_full |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 |
title_fullStr |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 |
title_full_unstemmed |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 |
title_sort |
Population expansion in the North Africa Late Pleistocene signalled by mitochondrial DNA haplogroup U6 |
author |
Pereira, L |
author_facet |
Pereira, L Silva, NM Franco-Duarte, R Fernandes, V Pereira, JB Costa, MD Martins, H Soares, P Behar, DM Richards, MB Macaulay, V |
author_role |
author |
author2 |
Silva, NM Franco-Duarte, R Fernandes, V Pereira, JB Costa, MD Martins, H Soares, P Behar, DM Richards, MB Macaulay, V |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, L Silva, NM Franco-Duarte, R Fernandes, V Pereira, JB Costa, MD Martins, H Soares, P Behar, DM Richards, MB Macaulay, V |
dc.subject.por.fl_str_mv |
Africa Northern African Continental Ancestry Group/genetics Bayes Theorem DNA Mitochondrial/genetics Europe Evolution, Molecular Genetics, Population Genome Human Haplotypes Humans Likelihood Functions Mutation Phylogeny Phylogeography Selection Genetic |
topic |
Africa Northern African Continental Ancestry Group/genetics Bayes Theorem DNA Mitochondrial/genetics Europe Evolution, Molecular Genetics, Population Genome Human Haplotypes Humans Likelihood Functions Mutation Phylogeny Phylogeography Selection Genetic |
description |
BACKGROUND: The archaeology of North Africa remains enigmatic, with questions of population continuity versus discontinuity taking centre-stage. Debates have focused on population transitions between the bearers of the Middle Palaeolithic Aterian industry and the later Upper Palaeolithic populations of the Maghreb, as well as between the late Pleistocene and Holocene. RESULTS: Improved resolution of the mitochondrial DNA (mtDNA) haplogroup U6 phylogeny, by the screening of 39 new complete sequences, has enabled us to infer a signal of moderate population expansion using Bayesian coalescent methods. To ascertain the time for this expansion, we applied both a mutation rate accounting for purifying selection and one with an internal calibration based on four approximate archaeological dates: the settlement of the Canary Islands, the settlement of Sardinia and its internal population re-expansion, and the split between haplogroups U5 and U6 around the time of the first modern human settlement of the Near East. CONCLUSIONS: A Bayesian skyline plot placed the main expansion in the time frame of the Late Pleistocene, around 20 ka, and spatial smoothing techniques suggested that the most probable geographic region for this demographic event was to the west of North Africa. A comparison with U6's European sister clade, U5, revealed a stronger population expansion at around this time in Europe. Also in contrast with U5, a weak signal of a recent population expansion in the last 5,000 years was observed in North Africa, pointing to a moderate impact of the late Neolithic on the local population size of the southern Mediterranean coast. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2010-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10216/109257 |
url |
http://hdl.handle.net/10216/109257 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1471-2148 10.1186/1471-2148-10-390 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/msword application/vnd.ms-excel |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135915973541889 |