Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784 |
Resumo: | Objectives: Although the breast cancer incidence in Portugal is lower than the European average, it is the most frequent cancer in women. Overall, mortality rates are heterogeneous throughout Portugal. Implicated factors may include demographic and socioeconomic aspects, tumor biological characteristics, and access to medical care. The aim of this study is to detect survival differences in female breast cancer and identify the main associated factors.Material and Methods: We have conducted a population-based, retrospective cohort study with follow-up. Incident breast cancer cases diagnosed in 2005 of residents in the southern region of Portugal were included. Data was collected from the Southern Portugal Cancer Registry (ROR-Sul) database and completed with clinical chart information.Results: A total of 1 354 patients were included in this study. Observed geographical variations were as follows: for age distribution, with an aging population in Alentejo; for tumor sub-types, there was a higher incidence of HER2-positive tumors in the Algarve and a higher incidence of HER2-negative tumors in Região Autónoma da Madeira. Reported estimated 5-year overall survival was 80%, with significant association with tumor stage, hormone receptor and HER2 status. No survival differences were identified among women from distinct geographical regions.Discussion: Although we found differences in age and tumor sub-type distribution between geographical regions, our study does not support the existence of discrepancies in breast cancer survival between these regions. Tumor biological characteristics seem to be the main associated factor with breast cancer survival in our population.Conclusions: Our study confirms the association between patient survival and tumor stage, hormone receptor and HER2 status. However, no differences in patient survival were observed among different regions of residence.Keywords: Breast Neoplasms; Neoplasm Staging; Survival Analysis; Portugal. |
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Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in PortugalSobrevivência de Cancro da Mama e Factores Associados: Resultados do Registo Oncológico Regional SulObjectives: Although the breast cancer incidence in Portugal is lower than the European average, it is the most frequent cancer in women. Overall, mortality rates are heterogeneous throughout Portugal. Implicated factors may include demographic and socioeconomic aspects, tumor biological characteristics, and access to medical care. The aim of this study is to detect survival differences in female breast cancer and identify the main associated factors.Material and Methods: We have conducted a population-based, retrospective cohort study with follow-up. Incident breast cancer cases diagnosed in 2005 of residents in the southern region of Portugal were included. Data was collected from the Southern Portugal Cancer Registry (ROR-Sul) database and completed with clinical chart information.Results: A total of 1 354 patients were included in this study. Observed geographical variations were as follows: for age distribution, with an aging population in Alentejo; for tumor sub-types, there was a higher incidence of HER2-positive tumors in the Algarve and a higher incidence of HER2-negative tumors in Região Autónoma da Madeira. Reported estimated 5-year overall survival was 80%, with significant association with tumor stage, hormone receptor and HER2 status. No survival differences were identified among women from distinct geographical regions.Discussion: Although we found differences in age and tumor sub-type distribution between geographical regions, our study does not support the existence of discrepancies in breast cancer survival between these regions. Tumor biological characteristics seem to be the main associated factor with breast cancer survival in our population.Conclusions: Our study confirms the association between patient survival and tumor stage, hormone receptor and HER2 status. However, no differences in patient survival were observed among different regions of residence.Keywords: Breast Neoplasms; Neoplasm Staging; Survival Analysis; Portugal.Objectivos: A incidência do cancro da mama em Portugal é inferior à média europeia, sendo, ainda assim, a neoplasia mais frequente na mulher. As taxas de mortalidade por cancro de mama apresentam uma distribuição heterogénea nas diferentes regiões de Portugal. São múltiplos os factores que podem influenciar esta distribuição, incluindo aspectos demográficos e socioeconómicos, características biológicas tumorais, e o acesso aos cuidados de saúde. O objectivo deste estudo é detectar diferenças na sobrevivência do cancro de mama feminino e os principais factores associados.Material e Métodos: Estudo de coorte, de base populacional e orientação retrospectiva, com follow-up. Foram incluídos casos de cancro de mama diagnosticados em 2005 e residentes na região sul de Portugal, tendo os dados sido recolhidos a partir da base de dados do Registo Oncológico Regional Sul (ROR-Sul) e complementados com dados dos processos clínicos.Resultados: Foram incluídos neste estudo 1 354 doentes. Observaram-se as seguintes variações geográficas: na distribuição etária, com uma população envelhecida no Alentejo; na distribuição de sub-tipos tumorais, com uma maior incidência de tumores HER2- positivo no Algarve e maior incidência de tumores HER2-negativo na Região Autónoma da Madeira. A sobrevivência global estimada aos 5 anos foi de 80%, com uma associação significativa com o estadio, receptores hormonais e status HER2. Não foram identificadas diferenças na sobrevivência entre mulheres residentes em regiões geográficas distintas.Discussão: Apesar das diferenças observadas na distribuição etária e de sub-tipos tumorais entre regiões geográficas, os nossos resultados não suportam a existência de discrepâncias na sobrevivência do cancro de mama entre estas regiões. As características biológicas tumorais parecem ser os principais factores associados à sobrevivência do cancro de mama feminino na nossa população.Conclusões: O nosso estudo confirma a associação entre a sobrevivência e o estadio, receptores hormonais e status HER2. No entanto, não foram observadas diferenças na sobrevivência entre diferentes regiões geográficas de residência.Palavras-chave: Neoplasias da Mama; Estadiamento de Neoplasias; Análise de Sobrevida; Portugal.Ordem dos Médicos2014-06-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegimage/jpegimage/jpegimage/jpegapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784oai:ojs.www.actamedicaportuguesa.com:article/4784Acta Médica Portuguesa; Vol. 27 No. 3 (2014): May-June; 325-330Acta Médica Portuguesa; Vol. 27 N.º 3 (2014): Maio-Junho; 325-3301646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/3981https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6969https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6970https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6971https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6972https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/7270André, Maria do RosarioAmaral, SandraMayer, AlexandraMiranda, AnaROR SUL, Working Groupinfo:eu-repo/semantics/openAccess2022-12-20T11:03:59Zoai:ojs.www.actamedicaportuguesa.com:article/4784Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:58.466517Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal Sobrevivência de Cancro da Mama e Factores Associados: Resultados do Registo Oncológico Regional Sul |
title |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal |
spellingShingle |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal André, Maria do Rosario |
title_short |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal |
title_full |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal |
title_fullStr |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal |
title_full_unstemmed |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal |
title_sort |
Breast Cancer Patients Survival and Associated Factors: Reported Outcomes from the Southern Cancer Registry in Portugal |
author |
André, Maria do Rosario |
author_facet |
André, Maria do Rosario Amaral, Sandra Mayer, Alexandra Miranda, Ana ROR SUL, Working Group |
author_role |
author |
author2 |
Amaral, Sandra Mayer, Alexandra Miranda, Ana ROR SUL, Working Group |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
André, Maria do Rosario Amaral, Sandra Mayer, Alexandra Miranda, Ana ROR SUL, Working Group |
description |
Objectives: Although the breast cancer incidence in Portugal is lower than the European average, it is the most frequent cancer in women. Overall, mortality rates are heterogeneous throughout Portugal. Implicated factors may include demographic and socioeconomic aspects, tumor biological characteristics, and access to medical care. The aim of this study is to detect survival differences in female breast cancer and identify the main associated factors.Material and Methods: We have conducted a population-based, retrospective cohort study with follow-up. Incident breast cancer cases diagnosed in 2005 of residents in the southern region of Portugal were included. Data was collected from the Southern Portugal Cancer Registry (ROR-Sul) database and completed with clinical chart information.Results: A total of 1 354 patients were included in this study. Observed geographical variations were as follows: for age distribution, with an aging population in Alentejo; for tumor sub-types, there was a higher incidence of HER2-positive tumors in the Algarve and a higher incidence of HER2-negative tumors in Região Autónoma da Madeira. Reported estimated 5-year overall survival was 80%, with significant association with tumor stage, hormone receptor and HER2 status. No survival differences were identified among women from distinct geographical regions.Discussion: Although we found differences in age and tumor sub-type distribution between geographical regions, our study does not support the existence of discrepancies in breast cancer survival between these regions. Tumor biological characteristics seem to be the main associated factor with breast cancer survival in our population.Conclusions: Our study confirms the association between patient survival and tumor stage, hormone receptor and HER2 status. However, no differences in patient survival were observed among different regions of residence.Keywords: Breast Neoplasms; Neoplasm Staging; Survival Analysis; Portugal. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784 oai:ojs.www.actamedicaportuguesa.com:article/4784 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784 |
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oai:ojs.www.actamedicaportuguesa.com:article/4784 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/3981 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6969 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6970 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6971 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/6972 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4784/7270 |
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Ordem dos Médicos |
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Ordem dos Médicos |
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Acta Médica Portuguesa; Vol. 27 No. 3 (2014): May-June; 325-330 Acta Médica Portuguesa; Vol. 27 N.º 3 (2014): Maio-Junho; 325-330 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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