Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/14303 |
Resumo: | We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imagingTriazaOrthogonal protectionBifunctional chelatorsGalliumRadiopharmacyIntegrin αѵβ₃receptorIntegrin alpha(v)beta(3) receptorIntegrin a ß receptor ? 3Integrin α β receptor ν 3Science & TechnologyWe report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line.Fundação para a Ciência e a Tecnologia (FCT)ElsevierUniversidade do MinhoSá, Arsénio VasconcelosMatias, Áurea A.Prata, M. Isabel M.Geraldes, Carlos F. G. C.Ferreira, Paula M. T.André, João P.20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/14303eng0960-894X10.1016/j.bmcl.2010.10.05921106453info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:04:22Zoai:repositorium.sdum.uminho.pt:1822/14303Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:54:39.888430Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
title |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
spellingShingle |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging Sá, Arsénio Vasconcelos Triaza Orthogonal protection Bifunctional chelators Gallium Radiopharmacy Integrin αѵβ₃receptor Integrin alpha(v)beta(3) receptor Integrin a ß receptor ? 3 Integrin α β receptor ν 3 Science & Technology |
title_short |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
title_full |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
title_fullStr |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
title_full_unstemmed |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
title_sort |
Gallium labeled NOTA-based conjugates for peptide receptor-mediated medical imaging |
author |
Sá, Arsénio Vasconcelos |
author_facet |
Sá, Arsénio Vasconcelos Matias, Áurea A. Prata, M. Isabel M. Geraldes, Carlos F. G. C. Ferreira, Paula M. T. André, João P. |
author_role |
author |
author2 |
Matias, Áurea A. Prata, M. Isabel M. Geraldes, Carlos F. G. C. Ferreira, Paula M. T. André, João P. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Sá, Arsénio Vasconcelos Matias, Áurea A. Prata, M. Isabel M. Geraldes, Carlos F. G. C. Ferreira, Paula M. T. André, João P. |
dc.subject.por.fl_str_mv |
Triaza Orthogonal protection Bifunctional chelators Gallium Radiopharmacy Integrin αѵβ₃receptor Integrin alpha(v)beta(3) receptor Integrin a ß receptor ? 3 Integrin α β receptor ν 3 Science & Technology |
topic |
Triaza Orthogonal protection Bifunctional chelators Gallium Radiopharmacy Integrin αѵβ₃receptor Integrin alpha(v)beta(3) receptor Integrin a ß receptor ? 3 Integrin α β receptor ν 3 Science & Technology |
description |
We report a straightforward and efficient synthetic strategy for the synthesis of three model glycine-arginine-glycine-aspartic-glycine (GRGDG) conjugates based on derivatives of NOTA and of their Ga(III) complexes targeted to the integrin αѵβ₃receptor. 71Ga NMR spectroscopy showed that the Ga(III)-labeled conjugates are highly stable in aqueous solution. The 67Ga-labeled conjugates proved to have high kinetic stability and showed a weak but specific binding to the receptors in a U87MG-glioblastoma cell line. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 2010-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/14303 |
url |
http://hdl.handle.net/1822/14303 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0960-894X 10.1016/j.bmcl.2010.10.059 21106453 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132329607692288 |