Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort

Detalhes bibliográficos
Autor(a) principal: Castagné, R
Data de Publicação: 2018
Outros Autores: Garès, V, Karimi, M, Chadeau-Hyam, M, Vineis, P, Delpierre, C, Kelly-Irving, M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/113058
Resumo: The concept of allostatic load (AL) refers to the idea of a global physiological 'wear and tear' resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL on mortality, we use data from the 1958 British birth cohort including eleven year mortality in 8,113 adults. Specifically, we interrogate the hypothesis of a cumulative biological risk (allostatic load) reflecting 4 physiological systems potentially predicting future risk of death (N = 132). AL was defined using 14 biomarkers assayed in blood from a biosample collected at 44 years of age. Cox proportional hazard regression analysis revealed that higher allostatic load at 44 years old was a significant predictor of mortality 11 years later [HR = 3.56 (2.3 to 5.53)]. We found that this relationship was not solely related to early-life SEP, adverse childhood experiences and young adulthood health status, behaviours and SEP [HR = 2.57 (1.59 to 4.15)]. Regarding the ability of each physiological system and biomarkers to predict future death, our results suggest that the cumulative measure was advantageous compared to evaluating each physiological system sub-score and biomarker separately. Our findings add some evidence of a biological embodiment in response to stress which ultimately affects mortality.
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spelling Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohortAllostatic loadMortalitySocioeconomical statusThe concept of allostatic load (AL) refers to the idea of a global physiological 'wear and tear' resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL on mortality, we use data from the 1958 British birth cohort including eleven year mortality in 8,113 adults. Specifically, we interrogate the hypothesis of a cumulative biological risk (allostatic load) reflecting 4 physiological systems potentially predicting future risk of death (N = 132). AL was defined using 14 biomarkers assayed in blood from a biosample collected at 44 years of age. Cox proportional hazard regression analysis revealed that higher allostatic load at 44 years old was a significant predictor of mortality 11 years later [HR = 3.56 (2.3 to 5.53)]. We found that this relationship was not solely related to early-life SEP, adverse childhood experiences and young adulthood health status, behaviours and SEP [HR = 2.57 (1.59 to 4.15)]. Regarding the ability of each physiological system and biomarkers to predict future death, our results suggest that the cumulative measure was advantageous compared to evaluating each physiological system sub-score and biomarker separately. Our findings add some evidence of a biological embodiment in response to stress which ultimately affects mortality.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/113058eng1573-728410.1007/s10654-018-0364-1Castagné, RGarès, VKarimi, MChadeau-Hyam, MVineis, PDelpierre, CKelly-Irving, Minfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:37:36Zoai:repositorio-aberto.up.pt:10216/113058Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:44:11.586433Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
title Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
spellingShingle Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
Castagné, R
Allostatic load
Mortality
Socioeconomical status
title_short Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
title_full Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
title_fullStr Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
title_full_unstemmed Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
title_sort Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
author Castagné, R
author_facet Castagné, R
Garès, V
Karimi, M
Chadeau-Hyam, M
Vineis, P
Delpierre, C
Kelly-Irving, M
author_role author
author2 Garès, V
Karimi, M
Chadeau-Hyam, M
Vineis, P
Delpierre, C
Kelly-Irving, M
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castagné, R
Garès, V
Karimi, M
Chadeau-Hyam, M
Vineis, P
Delpierre, C
Kelly-Irving, M
dc.subject.por.fl_str_mv Allostatic load
Mortality
Socioeconomical status
topic Allostatic load
Mortality
Socioeconomical status
description The concept of allostatic load (AL) refers to the idea of a global physiological 'wear and tear' resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL on mortality, we use data from the 1958 British birth cohort including eleven year mortality in 8,113 adults. Specifically, we interrogate the hypothesis of a cumulative biological risk (allostatic load) reflecting 4 physiological systems potentially predicting future risk of death (N = 132). AL was defined using 14 biomarkers assayed in blood from a biosample collected at 44 years of age. Cox proportional hazard regression analysis revealed that higher allostatic load at 44 years old was a significant predictor of mortality 11 years later [HR = 3.56 (2.3 to 5.53)]. We found that this relationship was not solely related to early-life SEP, adverse childhood experiences and young adulthood health status, behaviours and SEP [HR = 2.57 (1.59 to 4.15)]. Regarding the ability of each physiological system and biomarkers to predict future death, our results suggest that the cumulative measure was advantageous compared to evaluating each physiological system sub-score and biomarker separately. Our findings add some evidence of a biological embodiment in response to stress which ultimately affects mortality.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/113058
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 1573-7284
10.1007/s10654-018-0364-1
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