Pregnancy and its role in breast cancer

Detalhes bibliográficos
Autor(a) principal: Martins, Filipe
Data de Publicação: 2008
Outros Autores: Botelho, Maria, Laranjo, Mafalda, Cabrita, António, Torgal, Maria, Oliveira, Carlos de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/8494
https://doi.org/10.1007/s12156-008-0069-x
Resumo: Abstract Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.
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spelling Pregnancy and its role in breast cancerAbstract Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/8494http://hdl.handle.net/10316/8494https://doi.org/10.1007/s12156-008-0069-xengMartins, FilipeBotelho, MariaLaranjo, MafaldaCabrita, AntónioTorgal, MariaOliveira, Carlos deinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-27T16:14:34Zoai:estudogeral.uc.pt:10316/8494Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:43:34.941933Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pregnancy and its role in breast cancer
title Pregnancy and its role in breast cancer
spellingShingle Pregnancy and its role in breast cancer
Martins, Filipe
title_short Pregnancy and its role in breast cancer
title_full Pregnancy and its role in breast cancer
title_fullStr Pregnancy and its role in breast cancer
title_full_unstemmed Pregnancy and its role in breast cancer
title_sort Pregnancy and its role in breast cancer
author Martins, Filipe
author_facet Martins, Filipe
Botelho, Maria
Laranjo, Mafalda
Cabrita, António
Torgal, Maria
Oliveira, Carlos de
author_role author
author2 Botelho, Maria
Laranjo, Mafalda
Cabrita, António
Torgal, Maria
Oliveira, Carlos de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Martins, Filipe
Botelho, Maria
Laranjo, Mafalda
Cabrita, António
Torgal, Maria
Oliveira, Carlos de
description Abstract Early full-term pregnancy is the only recognized factor able to prevent breast cancer. There are several hypotheses to explain the mechanisms of this protection, namely an altered hormonal milieu, a differentiation process or a switch in stem cell properties. To explore them, authors have been using animal models, mainly in rodents. Hormonal administration with estrogen and progesterone was the most widely used process to mimic the mammary changes during pregnancy. We have recently proposed that this enigmatic protective role of a full-term birth in breast cancer is carried out by tumor inhibition mediated by differentiated mammary epithelial cells. This explanation may give a new perspective of breast cancer prevention and treatment.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/8494
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https://doi.org/10.1007/s12156-008-0069-x
url http://hdl.handle.net/10316/8494
https://doi.org/10.1007/s12156-008-0069-x
dc.language.iso.fl_str_mv eng
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