Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/57847 |
Resumo: | Background: The Stroop test is frequently used to assess deficits in inhibitory control in people with multiple sclerosis (MS). This test has limitations and antisaccade eye movements, that also measure inhibitory control, may be an alternative to Stroop.Objectives: The aim of this study was twofold: (i) to investigate if the performance in the antisaccade task is altered in patients with MS and (ii) to investigate the correlation between performances in neuropsychological tests, the Stroop test and the antisaccade task.Methods: We measured antisaccades (AS) parameters with an infrared eye tracker (SMIRED 250 Hz) using a standard AS paradigm. A total of 38 subjects diagnosed with MS and 38 age and gender matched controls participated in this study. Neuropsychological measures were obtained from the MS group.Results: Patients with MS have higher error rates and prolonged latency than controls in the antisaccade task. There was a consistent association between the Stroop performance and AS latency. Stroop performance but not AS latency was associated with other neuropsychological measures in which the MS group showed deficits.Conclusions: Our findings suggest that AS may be a selective and independent measure to investigate inhibitory control in patients with MS. More studies are necessary to confirm our results and to describe brain correlates associated with impaired performance in the antisaccade task in people diagnosed with MS. |
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Relationships between neuropsychological and antisaccade measures in multiple sclerosis patientsEye movementsAntisaccadesMultiple sclerosisStroop testInhibitory controlExecutive functionsCiências Médicas::Medicina BásicaScience & TechnologyBackground: The Stroop test is frequently used to assess deficits in inhibitory control in people with multiple sclerosis (MS). This test has limitations and antisaccade eye movements, that also measure inhibitory control, may be an alternative to Stroop.Objectives: The aim of this study was twofold: (i) to investigate if the performance in the antisaccade task is altered in patients with MS and (ii) to investigate the correlation between performances in neuropsychological tests, the Stroop test and the antisaccade task.Methods: We measured antisaccades (AS) parameters with an infrared eye tracker (SMIRED 250 Hz) using a standard AS paradigm. A total of 38 subjects diagnosed with MS and 38 age and gender matched controls participated in this study. Neuropsychological measures were obtained from the MS group.Results: Patients with MS have higher error rates and prolonged latency than controls in the antisaccade task. There was a consistent association between the Stroop performance and AS latency. Stroop performance but not AS latency was associated with other neuropsychological measures in which the MS group showed deficits.Conclusions: Our findings suggest that AS may be a selective and independent measure to investigate inhibitory control in patients with MS. More studies are necessary to confirm our results and to describe brain correlates associated with impaired performance in the antisaccade task in people diagnosed with MS.The Vision Rehabilitation Lab and Antonio Filipe Macedo receive or received funding from Shamir Optical Industry Lt, Portugal, from grants PTDC/DTP-EPI/0412/2012 (Prevalence and Costs of Visual Impairment in Portugal) and UID/FIS/04650/2013 (Framework of the Strategic Funding granted to Centre of Physics at Minho University). Multiple Sclerosis Association "Todos com a Esclerose Multiple" paid the salary of Marisa Borges Ferreira. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.info:eu-repo/semantics/publishedVersionPeerj, Inc.Universidade do MinhoFerreira, Marisa BorgesPereira, Paulo A.Parreira, MartaSousa, InesFigueiredo, JoséCerqueira, João JoséMacedo, Antonio Filipe20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57847engFerreira, M. B., Pereira, P. A., Parreira, M., Sousa, I., Figueiredo, J., Cerqueira, J. J., & Macedo, A. F. (2018). Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients. PeerJ, 6, e57372167-835910.7717/peerj.5737https://peerj.com/articles/5737/?utm_source=TrendMD&utm_campaign=PeerJ_TrendMD_1&utm_medium=TrendMDinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:58:13Zoai:repositorium.sdum.uminho.pt:1822/57847Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:55.418728Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients |
title |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients |
spellingShingle |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients Ferreira, Marisa Borges Eye movements Antisaccades Multiple sclerosis Stroop test Inhibitory control Executive functions Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients |
title_full |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients |
title_fullStr |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients |
title_full_unstemmed |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients |
title_sort |
Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients |
author |
Ferreira, Marisa Borges |
author_facet |
Ferreira, Marisa Borges Pereira, Paulo A. Parreira, Marta Sousa, Ines Figueiredo, José Cerqueira, João José Macedo, Antonio Filipe |
author_role |
author |
author2 |
Pereira, Paulo A. Parreira, Marta Sousa, Ines Figueiredo, José Cerqueira, João José Macedo, Antonio Filipe |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Ferreira, Marisa Borges Pereira, Paulo A. Parreira, Marta Sousa, Ines Figueiredo, José Cerqueira, João José Macedo, Antonio Filipe |
dc.subject.por.fl_str_mv |
Eye movements Antisaccades Multiple sclerosis Stroop test Inhibitory control Executive functions Ciências Médicas::Medicina Básica Science & Technology |
topic |
Eye movements Antisaccades Multiple sclerosis Stroop test Inhibitory control Executive functions Ciências Médicas::Medicina Básica Science & Technology |
description |
Background: The Stroop test is frequently used to assess deficits in inhibitory control in people with multiple sclerosis (MS). This test has limitations and antisaccade eye movements, that also measure inhibitory control, may be an alternative to Stroop.Objectives: The aim of this study was twofold: (i) to investigate if the performance in the antisaccade task is altered in patients with MS and (ii) to investigate the correlation between performances in neuropsychological tests, the Stroop test and the antisaccade task.Methods: We measured antisaccades (AS) parameters with an infrared eye tracker (SMIRED 250 Hz) using a standard AS paradigm. A total of 38 subjects diagnosed with MS and 38 age and gender matched controls participated in this study. Neuropsychological measures were obtained from the MS group.Results: Patients with MS have higher error rates and prolonged latency than controls in the antisaccade task. There was a consistent association between the Stroop performance and AS latency. Stroop performance but not AS latency was associated with other neuropsychological measures in which the MS group showed deficits.Conclusions: Our findings suggest that AS may be a selective and independent measure to investigate inhibitory control in patients with MS. More studies are necessary to confirm our results and to describe brain correlates associated with impaired performance in the antisaccade task in people diagnosed with MS. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/57847 |
url |
http://hdl.handle.net/1822/57847 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira, M. B., Pereira, P. A., Parreira, M., Sousa, I., Figueiredo, J., Cerqueira, J. J., & Macedo, A. F. (2018). Relationships between neuropsychological and antisaccade measures in multiple sclerosis patients. PeerJ, 6, e5737 2167-8359 10.7717/peerj.5737 https://peerj.com/articles/5737/?utm_source=TrendMD&utm_campaign=PeerJ_TrendMD_1&utm_medium=TrendMD |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Peerj, Inc. |
publisher.none.fl_str_mv |
Peerj, Inc. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132239759409152 |