HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8378 |
Resumo: | The HBM4EU Chromates study team consists of: Kukka Aimonen1, Rob Anzion2, Radia Bousoumah3, Maurice van Dael2, Karen S. Galea4, Ivo Iavicoli5, Kate Jones6, Henriqueta Louro2, Sophie Ndaw7, Simo P. Porras1, Edna Riberio8, and Riitta Velin1 Statistical team consist of: Natalia Buławska9, Dominika Jurkiewicz9 Correspondent affiliations: 1 Finnish Institute of Occupational Health, 00250 Helsinki, Finland; 2 Human Genetics Department, National Institute of Health Dr. Ricardo Jorge (INSA), Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade Nova de Lisboa, 1649-016 Lisbon, Portugal; 3 Comprehensive Health Research Center (CHRC), 1169-056, Lisbon, Portugal; 4 Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK; 5 Department of Public Health, University of Naples Federico II, 80131 Naples, Italy; 6 Health and Safety Executive (HSE), Harpur Hill, Buxton SK17 9JN, UK; 7 French National Research and Safety Institute, 54500, Vandoeuvre-les-Nancy, France; 8 Public Health Research Centre, NOVA National School of Public Health, Universidade NOVA de Lisbon, 1600-560 Lisbon, Portugal; 9 QSAR Lab Ltd., 80172 Gdansk, Poland. |
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HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent ChromiumEnvironmental GenotoxicityBiomarkersHuman BiomonitoringMetabolic PathwaysEarly Biologic EffectsOccupational HealthGenotoxicidade AmbientalThe HBM4EU Chromates study team consists of: Kukka Aimonen1, Rob Anzion2, Radia Bousoumah3, Maurice van Dael2, Karen S. Galea4, Ivo Iavicoli5, Kate Jones6, Henriqueta Louro2, Sophie Ndaw7, Simo P. Porras1, Edna Riberio8, and Riitta Velin1 Statistical team consist of: Natalia Buławska9, Dominika Jurkiewicz9 Correspondent affiliations: 1 Finnish Institute of Occupational Health, 00250 Helsinki, Finland; 2 Human Genetics Department, National Institute of Health Dr. Ricardo Jorge (INSA), Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade Nova de Lisboa, 1649-016 Lisbon, Portugal; 3 Comprehensive Health Research Center (CHRC), 1169-056, Lisbon, Portugal; 4 Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK; 5 Department of Public Health, University of Naples Federico II, 80131 Naples, Italy; 6 Health and Safety Executive (HSE), Harpur Hill, Buxton SK17 9JN, UK; 7 French National Research and Safety Institute, 54500, Vandoeuvre-les-Nancy, France; 8 Public Health Research Centre, NOVA National School of Public Health, Universidade NOVA de Lisbon, 1600-560 Lisbon, Portugal; 9 QSAR Lab Ltd., 80172 Gdansk, Poland.This article belongs to the Special Issue Toxicometabolomics.Exposure to hexavalent chromium Cr(VI) may occur in several occupational activities, placing workers in many industries at risk for potential related health outcomes. Untargeted metabolomics was applied to investigate changes in metabolic pathways in response to Cr(VI) exposure. We obtained our data from a study population of 220 male workers with exposure to Cr(VI) and 102 male controls from Belgium, Finland, Poland, Portugal and the Netherlands within the HBM4EU Chromates Study. Urinary metabolite profiles were determined using liquid chromatography mass spectrometry, and differences between post-shift exposed workers and controls were analyzed using principal component analysis. Based on the first two principal components, we observed clustering by industrial chromate application, such as welding, chrome plating, and surface treatment, distinct from controls and not explained by smoking status or alcohol use. The changes in the abundancy of excreted metabolites observed in workers reflect fatty acid and monoamine neurotransmitter metabolism, oxidative modifications of amino acid residues, the excessive formation of abnormal amino acid metabolites and changes in steroid and thyrotropin-releasing hormones. The observed responses could also have resulted from work-related factors other than Cr(VI). Further targeted metabolomics studies are needed to better understand the observed modifications and further explore the suitability of urinary metabolites as early indicators of adverse effects associated with exposure to Cr(VI).Samples for this study were collected under the HBM4EU program. Metabolomics research was supported by the National Science Centre, Poland, grant number 2019/33B/NZ7/01441.MDPIRepositório Científico do Instituto Nacional de SaúdeKozłowska, LucynaSantonen, TiinaDuca, Radu CorneliuGodderis, LodeJagiello, KarolinaJanasik, BeataVan Nieuwenhuyse, AnPoels, KatrienPuzyn, TomaszScheepers, Paul T.J.Sijko, MonikaSilva, Maria JoãoSosnowska, AnitaViegas, SusanaVerdonck, JelleWąsowicz, WojciechHBM4EU Chromates Study TeamStatistical Team2022-12-05T12:39:50Z2022-04-182022-04-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8378engMetabolites. 2022 Apr 18;12(4):362. doi: 10.3390/metabo120403622218-198910.3390/metabo12040362info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:29Zoai:repositorio.insa.pt:10400.18/8378Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:55.854433Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
| title |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
| spellingShingle |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium Kozłowska, Lucyna Environmental Genotoxicity Biomarkers Human Biomonitoring Metabolic Pathways Early Biologic Effects Occupational Health Genotoxicidade Ambiental |
| title_short |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
| title_full |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
| title_fullStr |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
| title_full_unstemmed |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
| title_sort |
HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium |
| author |
Kozłowska, Lucyna |
| author_facet |
Kozłowska, Lucyna Santonen, Tiina Duca, Radu Corneliu Godderis, Lode Jagiello, Karolina Janasik, Beata Van Nieuwenhuyse, An Poels, Katrien Puzyn, Tomasz Scheepers, Paul T.J. Sijko, Monika Silva, Maria João Sosnowska, Anita Viegas, Susana Verdonck, Jelle Wąsowicz, Wojciech HBM4EU Chromates Study Team Statistical Team |
| author_role |
author |
| author2 |
Santonen, Tiina Duca, Radu Corneliu Godderis, Lode Jagiello, Karolina Janasik, Beata Van Nieuwenhuyse, An Poels, Katrien Puzyn, Tomasz Scheepers, Paul T.J. Sijko, Monika Silva, Maria João Sosnowska, Anita Viegas, Susana Verdonck, Jelle Wąsowicz, Wojciech HBM4EU Chromates Study Team Statistical Team |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Kozłowska, Lucyna Santonen, Tiina Duca, Radu Corneliu Godderis, Lode Jagiello, Karolina Janasik, Beata Van Nieuwenhuyse, An Poels, Katrien Puzyn, Tomasz Scheepers, Paul T.J. Sijko, Monika Silva, Maria João Sosnowska, Anita Viegas, Susana Verdonck, Jelle Wąsowicz, Wojciech HBM4EU Chromates Study Team Statistical Team |
| dc.subject.por.fl_str_mv |
Environmental Genotoxicity Biomarkers Human Biomonitoring Metabolic Pathways Early Biologic Effects Occupational Health Genotoxicidade Ambiental |
| topic |
Environmental Genotoxicity Biomarkers Human Biomonitoring Metabolic Pathways Early Biologic Effects Occupational Health Genotoxicidade Ambiental |
| description |
The HBM4EU Chromates study team consists of: Kukka Aimonen1, Rob Anzion2, Radia Bousoumah3, Maurice van Dael2, Karen S. Galea4, Ivo Iavicoli5, Kate Jones6, Henriqueta Louro2, Sophie Ndaw7, Simo P. Porras1, Edna Riberio8, and Riitta Velin1 Statistical team consist of: Natalia Buławska9, Dominika Jurkiewicz9 Correspondent affiliations: 1 Finnish Institute of Occupational Health, 00250 Helsinki, Finland; 2 Human Genetics Department, National Institute of Health Dr. Ricardo Jorge (INSA), Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade Nova de Lisboa, 1649-016 Lisbon, Portugal; 3 Comprehensive Health Research Center (CHRC), 1169-056, Lisbon, Portugal; 4 Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK; 5 Department of Public Health, University of Naples Federico II, 80131 Naples, Italy; 6 Health and Safety Executive (HSE), Harpur Hill, Buxton SK17 9JN, UK; 7 French National Research and Safety Institute, 54500, Vandoeuvre-les-Nancy, France; 8 Public Health Research Centre, NOVA National School of Public Health, Universidade NOVA de Lisbon, 1600-560 Lisbon, Portugal; 9 QSAR Lab Ltd., 80172 Gdansk, Poland. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-05T12:39:50Z 2022-04-18 2022-04-18T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/8378 |
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http://hdl.handle.net/10400.18/8378 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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Metabolites. 2022 Apr 18;12(4):362. doi: 10.3390/metabo12040362 2218-1989 10.3390/metabo12040362 |
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MDPI |
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MDPI |
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