Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.

Detalhes bibliográficos
Autor(a) principal: Pereira, Olívia R.
Data de Publicação: 2019
Outros Autores: Macias, Rócio I.R., Domingues, Maria R.M., Marin, Jose J.G., Cardoso, Susana M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/19688
Resumo: The phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro . L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside were the major phenolic compounds of L. dentata and M. aquatica extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While L. cardiaca extract showed moderate biological effects, M. aquatica extract displayed high antioxidant activity in chemical models, and that of L. dentata was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, M. aquatica extract (50 μg/mL) and its mixture (50%/50%) with L. dentata extract displayed an effective cytoprotective effect.
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spelling Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.MenthaLavandulaLeonurusLiver diseasesHepG2 cellsAntioxidant;Phenolic compoundsUHPLC-DAD-ESI-MSnThe phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro . L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside were the major phenolic compounds of L. dentata and M. aquatica extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While L. cardiaca extract showed moderate biological effects, M. aquatica extract displayed high antioxidant activity in chemical models, and that of L. dentata was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, M. aquatica extract (50 μg/mL) and its mixture (50%/50%) with L. dentata extract displayed an effective cytoprotective effect.Aveiro and FCT/MCT financed the QOPNA research Unit (FCT UID/QUI/00062/2019) through national funds and, where applicable, co-financed by the FEDER, within the PT2020 Partnership Agreement, to the Portuguese NMR Network and to the Portuguese Mass Spectrometry Network (RNEM, LISBOA-01-0145-FEDER-402-022125). This study was supported in part by the CIBERehd (EHD15PI05/2016) and Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Spain (PI16/00598, co-funded by European Regional Development Fund/European Social Fund, “Investing in your future”); Spanish Ministry of Economy, Industry and Competitiveness (SAF2016-75197-R); Junta de Castilla y Leon (SA063P17); AECCScientific Foundation (2017/2020), Spain; and “Centro Internacional sobre el Envejecimiento” (OLD-HEPAMARKER, 0348_CIE_6_E), Spain. Project AgroForWealth (CENTRO-01-0145-FEDER-000001) funded by Centro2020, through FEDER and PT2020, financed the research contract of Susana M. Cardoso.MDPIBiblioteca Digital do IPBPereira, Olívia R.Macias, Rócio I.R.Domingues, Maria R.M.Marin, Jose J.G.Cardoso, Susana M.2019-10-23T11:24:32Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/19688engPereira, Olívia R.; Macias, Rocio I.R.; Domingues, Maria R.M.; Marin, Jose J.G.; Cardoso, Susana M. (2019). Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L. Antioxidants. ISSN 2076-3921. 8:8, p. 1-132076-392110.3390/antiox8080267info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:44:52Zoai:bibliotecadigital.ipb.pt:10198/19688Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:10:17.039005Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
title Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
spellingShingle Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
Pereira, Olívia R.
Mentha
Lavandula
Leonurus
Liver diseases
HepG2 cells
Antioxidant;
Phenolic compounds
UHPLC-DAD-ESI-MSn
title_short Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
title_full Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
title_fullStr Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
title_full_unstemmed Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
title_sort Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L.
author Pereira, Olívia R.
author_facet Pereira, Olívia R.
Macias, Rócio I.R.
Domingues, Maria R.M.
Marin, Jose J.G.
Cardoso, Susana M.
author_role author
author2 Macias, Rócio I.R.
Domingues, Maria R.M.
Marin, Jose J.G.
Cardoso, Susana M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Pereira, Olívia R.
Macias, Rócio I.R.
Domingues, Maria R.M.
Marin, Jose J.G.
Cardoso, Susana M.
dc.subject.por.fl_str_mv Mentha
Lavandula
Leonurus
Liver diseases
HepG2 cells
Antioxidant;
Phenolic compounds
UHPLC-DAD-ESI-MSn
topic Mentha
Lavandula
Leonurus
Liver diseases
HepG2 cells
Antioxidant;
Phenolic compounds
UHPLC-DAD-ESI-MSn
description The phenolic composition of hydroethanolic extracts of Mentha aquatica L., Lavandula dentata L. and Leonurus cardiaca L., obtained from plants grown under organic cultivation, was determined and their hepatoprotective effects were investigated in vitro . L. cardiaca extract was rich in phenylethenoid glycosides, especially lavandolifolioside (254 ± 36 μg/mg), whereas rosmarinic acid and eriodictyol-O-rutinoside were the major phenolic compounds of L. dentata and M. aquatica extracts, accounting for 68 ± 7 μg/mg and 145 ± 22 μg/mg, respectively. These differential phenolic components presumably account for their dissimilar antioxidant properties. While L. cardiaca extract showed moderate biological effects, M. aquatica extract displayed high antioxidant activity in chemical models, and that of L. dentata was effective in counteracting potassium dichromate-induced ROS generation in human hepatocarcinoma cells. Moreover, M. aquatica extract (50 μg/mL) and its mixture (50%/50%) with L. dentata extract displayed an effective cytoprotective effect.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-23T11:24:32Z
2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/19688
url http://hdl.handle.net/10198/19688
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pereira, Olívia R.; Macias, Rocio I.R.; Domingues, Maria R.M.; Marin, Jose J.G.; Cardoso, Susana M. (2019). Hepatoprotection of mentha aquatica L., lavandula dentata L. and leonurus cardiaca L. Antioxidants. ISSN 2076-3921. 8:8, p. 1-13
2076-3921
10.3390/antiox8080267
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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