Purines and carotid body: New roles in pathological conditions

Detalhes bibliográficos
Autor(a) principal: Conde, S.V.
Data de Publicação: 2017
Outros Autores: Monteiro, E.C., Sacramento, J.F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.3389/fphar.2017.00913
Resumo: JS is supported by Ph.D. Grant from the Portuguese Foundation for Science and Technology, PD/BD/105890/2014.
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spelling Purines and carotid body: New roles in pathological conditionsAdenosineATPCarotid bodyChronic intermittent hypoxiaHypertensionType 2 diabetesSDG 3 - Good Health and Well-beingJS is supported by Ph.D. Grant from the Portuguese Foundation for Science and Technology, PD/BD/105890/2014.It is known that adenosine and adenosine-5'-triphosphate (ATP) are excitatory mediators involved in carotid body (CB) hypoxic signaling. The CBs are peripheral chemoreceptors classically defined by O2, CO2, and pH sensors. When hypoxia activates the CB, it induces the release of neurotransmitters from chemoreceptor cells leading to an increase in the action potentials frequency at the carotid sinus nerve (CSN). This increase in the firing frequency of the CSN is integrated in the brainstem to induce cardiorespiratory compensatory responses. In the last decade several pathologies, as, hypertension, diabetes, obstructive sleep apnea and heart failure have been associated with CB overactivation. In the first section of the present manuscript we review in a concise manner fundamental aspects of purine metabolism. The second section is devoted to the role of purines on the hypoxic response of the CB, providing the state-of-the art for the presence of adenosine and ATP receptors in the CB; for the role of purines at presynaptic level in CB chemoreceptor cells, as well as, its metabolism and regulation; at postsynaptic level in the CSN activity; and on the ventilatory responses to hypoxia. Recently, we have showed that adenosine is involved in CB hypersensitization during chronic intermittent hypoxia (CIH), which mimics obstructive sleep apnea, since caffeine, a non-selective adenosine receptor antagonist that inhibits A2A and A2B adenosine receptors, decreased CSN chemosensory activity in animals subjected to CIH. Apart from this involvement of adenosine in CB sensitization in sleep apnea, it was recently found that P2X3 ATP receptor in the CB contributes to increased chemoreflex hypersensitivity and hypertension in spontaneously hypertension rats. Therefore the last section of this manuscript is devoted to review the recent findings on the role of purines in CB-mediated pathologies as hypertension, diabetes and sleep apnea emphasizing the potential clinical importance of modulating purines levels and action to treat pathologies associated with CB dysfunction. © 2017 Conde, Monteiro and Sacramento.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNConde, S.V.Monteiro, E.C.Sacramento, J.F.2017-12-28T23:10:52Z2017-12-122017-12-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.3389/fphar.2017.00913eng1663-9812PURE: 3409127https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037825630&doi=10.3389%2ffphar.2017.00913&partnerID=40&md5=be97fc0c2e04545a6b01d2a92c1e8bb7https://doi.org/10.3389/fphar.2017.00913info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:14:30Zoai:run.unl.pt:10362/27414Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:28:41.087848Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Purines and carotid body: New roles in pathological conditions
title Purines and carotid body: New roles in pathological conditions
spellingShingle Purines and carotid body: New roles in pathological conditions
Conde, S.V.
Adenosine
ATP
Carotid body
Chronic intermittent hypoxia
Hypertension
Type 2 diabetes
SDG 3 - Good Health and Well-being
title_short Purines and carotid body: New roles in pathological conditions
title_full Purines and carotid body: New roles in pathological conditions
title_fullStr Purines and carotid body: New roles in pathological conditions
title_full_unstemmed Purines and carotid body: New roles in pathological conditions
title_sort Purines and carotid body: New roles in pathological conditions
author Conde, S.V.
author_facet Conde, S.V.
Monteiro, E.C.
Sacramento, J.F.
author_role author
author2 Monteiro, E.C.
Sacramento, J.F.
author2_role author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Conde, S.V.
Monteiro, E.C.
Sacramento, J.F.
dc.subject.por.fl_str_mv Adenosine
ATP
Carotid body
Chronic intermittent hypoxia
Hypertension
Type 2 diabetes
SDG 3 - Good Health and Well-being
topic Adenosine
ATP
Carotid body
Chronic intermittent hypoxia
Hypertension
Type 2 diabetes
SDG 3 - Good Health and Well-being
description JS is supported by Ph.D. Grant from the Portuguese Foundation for Science and Technology, PD/BD/105890/2014.
publishDate 2017
dc.date.none.fl_str_mv 2017-12-28T23:10:52Z
2017-12-12
2017-12-12T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.3389/fphar.2017.00913
url https://doi.org/10.3389/fphar.2017.00913
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1663-9812
PURE: 3409127
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037825630&doi=10.3389%2ffphar.2017.00913&partnerID=40&md5=be97fc0c2e04545a6b01d2a92c1e8bb7
https://doi.org/10.3389/fphar.2017.00913
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