Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia

Detalhes bibliográficos
Autor(a) principal: Marques, Bárbara
Data de Publicação: 2022
Outros Autores: Afonso, Carolina, Cortesão, Emília
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770
Resumo: Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal proliferation, with increased incidence with advancing age. AML with myelodysplasia-related changes (AML-MRC) represents an AML subtype with a poor prognosis and challenging treatment, particularly in elderly patients. We report the case of a 77-year-old patient diagnosed with high-risk AML-MRC, ineligible for intensive chemotherapy, with frequent need of transfusion of red cell concentrates. The authors present, to the best of their knowledge, the first patient in Portugal with AML-MRC treated with an hypomethylating agent, azacytidine, and a BCL2 inhibitor (venetoclax), and that association was essential in the treatment and overall survival, which was much higher than expected.
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spelling Venetoclax: A New Hope for Elderly Patients with Acute Myeloid LeukemiaVenetoclax: Uma Nova Esperança para o Doente Idoso com Leucemia Mielóide AgudaAgedBridged Bicyclo CompoundsHeterocyclicLeukemiaMyeloidAcute/drug therapyCompostos Bicíclicos Heterocíclicos com PontesIdosoLeucemia Mielóide Aguda/tratamento formacológicoAcute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal proliferation, with increased incidence with advancing age. AML with myelodysplasia-related changes (AML-MRC) represents an AML subtype with a poor prognosis and challenging treatment, particularly in elderly patients. We report the case of a 77-year-old patient diagnosed with high-risk AML-MRC, ineligible for intensive chemotherapy, with frequent need of transfusion of red cell concentrates. The authors present, to the best of their knowledge, the first patient in Portugal with AML-MRC treated with an hypomethylating agent, azacytidine, and a BCL2 inhibitor (venetoclax), and that association was essential in the treatment and overall survival, which was much higher than expected.A leucemia mielóide aguda (LMA) é uma neoplasia hematológica caracterizada pela proliferação clonal, com incidência crescente com a idade. A LMA com alterações relacionadas com mielodisplasia (LMA-ARM) representa um subtipo de LMA com prognóstico adverso, cujo tratamento é desafiante, sobretudo nos doentes mais idosos. Descrevemos o caso de uma doente de 77 anos com o diagnóstico de LMA-ARM, de alto risco inelegível para quimioterapia intensiva, com necessidades transfusionais frequentes. Tanto quanto é do seu conhecimento, os autores apresentam o primeiro caso clínico de LMA-ARM, em Portugal, tratado com a associação do agente hipometilante, azaciditina, e o inibidor BCL2 (venetoclax), o que foi crucial para o tratamento e sobrevivência global do doente, muito além da sobrevivência esperada.Ordem dos Médicos2022-03-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770Acta Médica Portuguesa; Vol. 36 No. 1 (2023): Janeiro; 59-62Acta Médica Portuguesa; Vol. 36 N.º 1 (2023): Janeiro; 59-621646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770/6596Direitos de Autor (c) 2022 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessMarques, BárbaraAfonso, CarolinaCortesão, Emília2023-01-08T03:01:11Zoai:ojs.www.actamedicaportuguesa.com:article/17770Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:21:00.142937Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
Venetoclax: Uma Nova Esperança para o Doente Idoso com Leucemia Mielóide Aguda
title Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
spellingShingle Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
Marques, Bárbara
Aged
Bridged Bicyclo Compounds
Heterocyclic
Leukemia
Myeloid
Acute/drug therapy
Compostos Bicíclicos Heterocíclicos com Pontes
Idoso
Leucemia Mielóide Aguda/tratamento formacológico
title_short Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
title_full Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
title_fullStr Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
title_full_unstemmed Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
title_sort Venetoclax: A New Hope for Elderly Patients with Acute Myeloid Leukemia
author Marques, Bárbara
author_facet Marques, Bárbara
Afonso, Carolina
Cortesão, Emília
author_role author
author2 Afonso, Carolina
Cortesão, Emília
author2_role author
author
dc.contributor.author.fl_str_mv Marques, Bárbara
Afonso, Carolina
Cortesão, Emília
dc.subject.por.fl_str_mv Aged
Bridged Bicyclo Compounds
Heterocyclic
Leukemia
Myeloid
Acute/drug therapy
Compostos Bicíclicos Heterocíclicos com Pontes
Idoso
Leucemia Mielóide Aguda/tratamento formacológico
topic Aged
Bridged Bicyclo Compounds
Heterocyclic
Leukemia
Myeloid
Acute/drug therapy
Compostos Bicíclicos Heterocíclicos com Pontes
Idoso
Leucemia Mielóide Aguda/tratamento formacológico
description Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by clonal proliferation, with increased incidence with advancing age. AML with myelodysplasia-related changes (AML-MRC) represents an AML subtype with a poor prognosis and challenging treatment, particularly in elderly patients. We report the case of a 77-year-old patient diagnosed with high-risk AML-MRC, ineligible for intensive chemotherapy, with frequent need of transfusion of red cell concentrates. The authors present, to the best of their knowledge, the first patient in Portugal with AML-MRC treated with an hypomethylating agent, azacytidine, and a BCL2 inhibitor (venetoclax), and that association was essential in the treatment and overall survival, which was much higher than expected.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-29
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/17770/6596
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2022 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2022 Acta Médica Portuguesa
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 36 No. 1 (2023): Janeiro; 59-62
Acta Médica Portuguesa; Vol. 36 N.º 1 (2023): Janeiro; 59-62
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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