Helichrysum italicum: from traditional use to scientific data

Detalhes bibliográficos
Autor(a) principal: Viegas, Daniel Antunes
Data de Publicação: 2014
Outros Autores: Palmeira-de-Oliveira, Ana, Salgueiro, Lígia, Martinez-de-Oliveira, José, Palmeira-de-Oliveira, Rita
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/27162
https://doi.org/10.1016/j.jep.2013.11.005
Resumo: Ethnopharmacological relevance Helichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. This review aims to provide an overview of the current state of knowledge of the pharmacological activities of Helichrysum italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methods The selection of relevant data was made through a search using the keywords “Helichrysum italicum” and “H. italicum” in “Directory of Open Access Journals”, “Google Scholar”, “ISI Web of Knowledge”, “PubMed”, “ScienceDirect” and “Wiley Online Library”. Information obtained in local and foreign books and other sources was also included. Results There are reports on the traditional use of Helichrysum italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of Helichrysum italicum and highlight other potential applications for its extracts and isolated compounds, several scientific studies have been conducted in the last decades. In vitro studies characterized Helichrysum italicum as an antimicrobial and anti-inflammatory agent. Its flavonoids and terpenes were effective against bacteria (e.g. Staphylococcus aureus), its acetophenones, phloroglucinols and terpenoids displayed antifungal action against Candida albicans and its flavonoids and phloroglucinols inhibited HSV and HIV, respectively. Helichrysum italicum acetophenones, flavonoids and phloroglucinols demonstrated inhibitory action in different pathways of arachidonic acid metabolism and other pro-inflammatory mediators. Regarding Helichrysum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while Helichrysum italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Conclusions Helichrysum italicum is a medicinal plant with promising pharmacological activities. However, most of its traditionally claimed applications are not yet scientifically proven. Clinical trials are needed to further confirm these data and promote Helichrysum italicum as an important tool in the treatment of several diseases.
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spelling Helichrysum italicum: from traditional use to scientific dataHelichrysum italicumTraditional medicineEverlastingAnti-inflammatoryAntimicrobialEthnopharmacological relevance Helichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. This review aims to provide an overview of the current state of knowledge of the pharmacological activities of Helichrysum italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methods The selection of relevant data was made through a search using the keywords “Helichrysum italicum” and “H. italicum” in “Directory of Open Access Journals”, “Google Scholar”, “ISI Web of Knowledge”, “PubMed”, “ScienceDirect” and “Wiley Online Library”. Information obtained in local and foreign books and other sources was also included. Results There are reports on the traditional use of Helichrysum italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of Helichrysum italicum and highlight other potential applications for its extracts and isolated compounds, several scientific studies have been conducted in the last decades. In vitro studies characterized Helichrysum italicum as an antimicrobial and anti-inflammatory agent. Its flavonoids and terpenes were effective against bacteria (e.g. Staphylococcus aureus), its acetophenones, phloroglucinols and terpenoids displayed antifungal action against Candida albicans and its flavonoids and phloroglucinols inhibited HSV and HIV, respectively. Helichrysum italicum acetophenones, flavonoids and phloroglucinols demonstrated inhibitory action in different pathways of arachidonic acid metabolism and other pro-inflammatory mediators. Regarding Helichrysum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while Helichrysum italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Conclusions Helichrysum italicum is a medicinal plant with promising pharmacological activities. However, most of its traditionally claimed applications are not yet scientifically proven. Clinical trials are needed to further confirm these data and promote Helichrysum italicum as an important tool in the treatment of several diseases.Elsevier2014-01-10info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/27162http://hdl.handle.net/10316/27162https://doi.org/10.1016/j.jep.2013.11.005engVIEGAS, Daniel Antunes. [et al.] - Helichrysum italicum: from traditional use to scientific data. "Journal of Ethnopharmacology". ISSN 0378-8741. Vol. 151 Nº. 1 (2014) p. 54-650378-8741http://www.sciencedirect.com/science/article/pii/S037887411300799XViegas, Daniel AntunesPalmeira-de-Oliveira, AnaSalgueiro, LígiaMartinez-de-Oliveira, JoséPalmeira-de-Oliveira, Ritainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-05-25T07:45:15Zoai:estudogeral.uc.pt:10316/27162Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:28.717858Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Helichrysum italicum: from traditional use to scientific data
title Helichrysum italicum: from traditional use to scientific data
spellingShingle Helichrysum italicum: from traditional use to scientific data
Viegas, Daniel Antunes
Helichrysum italicum
Traditional medicine
Everlasting
Anti-inflammatory
Antimicrobial
title_short Helichrysum italicum: from traditional use to scientific data
title_full Helichrysum italicum: from traditional use to scientific data
title_fullStr Helichrysum italicum: from traditional use to scientific data
title_full_unstemmed Helichrysum italicum: from traditional use to scientific data
title_sort Helichrysum italicum: from traditional use to scientific data
author Viegas, Daniel Antunes
author_facet Viegas, Daniel Antunes
Palmeira-de-Oliveira, Ana
Salgueiro, Lígia
Martinez-de-Oliveira, José
Palmeira-de-Oliveira, Rita
author_role author
author2 Palmeira-de-Oliveira, Ana
Salgueiro, Lígia
Martinez-de-Oliveira, José
Palmeira-de-Oliveira, Rita
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Viegas, Daniel Antunes
Palmeira-de-Oliveira, Ana
Salgueiro, Lígia
Martinez-de-Oliveira, José
Palmeira-de-Oliveira, Rita
dc.subject.por.fl_str_mv Helichrysum italicum
Traditional medicine
Everlasting
Anti-inflammatory
Antimicrobial
topic Helichrysum italicum
Traditional medicine
Everlasting
Anti-inflammatory
Antimicrobial
description Ethnopharmacological relevance Helichrysum italicum (Roth) G. Don fil. (family Asteraceae) has been used for its medicinal properties for a long time and, even nowadays, continues to play an important role in the traditional medicine of Mediterranean countries. Based on this traditional knowledge, its different pharmacological activities have been the focus of active research. This review aims to provide an overview of the current state of knowledge of the pharmacological activities of Helichrysum italicum, as well as its traditional uses, toxicity, drug interactions and safety. Materials and methods The selection of relevant data was made through a search using the keywords “Helichrysum italicum” and “H. italicum” in “Directory of Open Access Journals”, “Google Scholar”, “ISI Web of Knowledge”, “PubMed”, “ScienceDirect” and “Wiley Online Library”. Information obtained in local and foreign books and other sources was also included. Results There are reports on the traditional use of Helichrysum italicum in European countries, particularly Italy, Spain, Portugal and Bosnia and Herzegovina. In these countries, its flowers and leaves are the most used parts in the treatment of health disorders such as allergies, colds, cough, skin, liver and gallbladder disorders, inflammation, infections and sleeplessness. In order to validate some of the traditional uses of Helichrysum italicum and highlight other potential applications for its extracts and isolated compounds, several scientific studies have been conducted in the last decades. In vitro studies characterized Helichrysum italicum as an antimicrobial and anti-inflammatory agent. Its flavonoids and terpenes were effective against bacteria (e.g. Staphylococcus aureus), its acetophenones, phloroglucinols and terpenoids displayed antifungal action against Candida albicans and its flavonoids and phloroglucinols inhibited HSV and HIV, respectively. Helichrysum italicum acetophenones, flavonoids and phloroglucinols demonstrated inhibitory action in different pathways of arachidonic acid metabolism and other pro-inflammatory mediators. Regarding Helichrysum italicum in vivo activity, the highlight goes to the anti-erythematous and photoprotective activities of its flavonoids, demonstrated both in animals and humans, and to the anti-inflammatory properties exhibited by its flavonoids, acetophenones and phloroglucinols, as seen in animal models. Concerning its safety and adverse effects, while Helichrysum italicum does not display significant levels of cytotoxicity or genotoxicity, it should be noticed that one of its flavonoids inhibited some CYP isoforms and a case has been reported of an allergic reaction to its extracts. Conclusions Helichrysum italicum is a medicinal plant with promising pharmacological activities. However, most of its traditionally claimed applications are not yet scientifically proven. Clinical trials are needed to further confirm these data and promote Helichrysum italicum as an important tool in the treatment of several diseases.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/27162
http://hdl.handle.net/10316/27162
https://doi.org/10.1016/j.jep.2013.11.005
url http://hdl.handle.net/10316/27162
https://doi.org/10.1016/j.jep.2013.11.005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv VIEGAS, Daniel Antunes. [et al.] - Helichrysum italicum: from traditional use to scientific data. "Journal of Ethnopharmacology". ISSN 0378-8741. Vol. 151 Nº. 1 (2014) p. 54-65
0378-8741
http://www.sciencedirect.com/science/article/pii/S037887411300799X
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dc.publisher.none.fl_str_mv Elsevier
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