Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Livro |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/152984 |
Resumo: | <jats:title>Abstract</jats:title><jats:p>The effectiveness of biomedical surfaces may be highly affected by the hydrodynamic condition. Surfaces releasing antimicrobial substances when exposed to flow may exhibit shorter lifetimes than at static conditions. Likewise, depending on the fluid flow surrounding the surface, contact-killing surfaces that are adhesive for bacterial cells may be covered by bacterial debris, which decreases their antimicrobial activity. To evaluate the anti-adhesive and antimicrobial performance of novel biomedical materials, a number of flow devices have been designed to recreate <jats:italic>in vivo</jats:italic> flow conditions. Shear stress and flow rate can be accurately controlled and varied in these <jats:italic>in vitro</jats:italic> flow systems, which requires prior knowledge of the flow dynamics inside the platform. After limiting their operational range, modified Robbins devices, flow chambers and microfluidic devices are suggested as experimental setups to mimic the flow behavior in urinary catheters and stents.</jats:p> |
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Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects<jats:title>Abstract</jats:title><jats:p>The effectiveness of biomedical surfaces may be highly affected by the hydrodynamic condition. Surfaces releasing antimicrobial substances when exposed to flow may exhibit shorter lifetimes than at static conditions. Likewise, depending on the fluid flow surrounding the surface, contact-killing surfaces that are adhesive for bacterial cells may be covered by bacterial debris, which decreases their antimicrobial activity. To evaluate the anti-adhesive and antimicrobial performance of novel biomedical materials, a number of flow devices have been designed to recreate <jats:italic>in vivo</jats:italic> flow conditions. Shear stress and flow rate can be accurately controlled and varied in these <jats:italic>in vitro</jats:italic> flow systems, which requires prior knowledge of the flow dynamics inside the platform. After limiting their operational range, modified Robbins devices, flow chambers and microfluidic devices are suggested as experimental setups to mimic the flow behavior in urinary catheters and stents.</jats:p>20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookapplication/pdfhttps://hdl.handle.net/10216/152984eng10.1007/978-3-031-04484-7_19Luciana GomesRita Teixeira dos SantosMaria João RomeuFilipe Mergulhãoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:12:12Zoai:repositorio-aberto.up.pt:10216/152984Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:35:49.096161Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects |
title |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects |
spellingShingle |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects Luciana Gomes |
title_short |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects |
title_full |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects |
title_fullStr |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects |
title_full_unstemmed |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects |
title_sort |
Bacterial Adhesion and Biofilm Formation: Hydrodynamics Effects |
author |
Luciana Gomes |
author_facet |
Luciana Gomes Rita Teixeira dos Santos Maria João Romeu Filipe Mergulhão |
author_role |
author |
author2 |
Rita Teixeira dos Santos Maria João Romeu Filipe Mergulhão |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Luciana Gomes Rita Teixeira dos Santos Maria João Romeu Filipe Mergulhão |
description |
<jats:title>Abstract</jats:title><jats:p>The effectiveness of biomedical surfaces may be highly affected by the hydrodynamic condition. Surfaces releasing antimicrobial substances when exposed to flow may exhibit shorter lifetimes than at static conditions. Likewise, depending on the fluid flow surrounding the surface, contact-killing surfaces that are adhesive for bacterial cells may be covered by bacterial debris, which decreases their antimicrobial activity. To evaluate the anti-adhesive and antimicrobial performance of novel biomedical materials, a number of flow devices have been designed to recreate <jats:italic>in vivo</jats:italic> flow conditions. Shear stress and flow rate can be accurately controlled and varied in these <jats:italic>in vitro</jats:italic> flow systems, which requires prior knowledge of the flow dynamics inside the platform. After limiting their operational range, modified Robbins devices, flow chambers and microfluidic devices are suggested as experimental setups to mimic the flow behavior in urinary catheters and stents.</jats:p> |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/book |
format |
book |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/152984 |
url |
https://hdl.handle.net/10216/152984 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1007/978-3-031-04484-7_19 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135669992292352 |