Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Ana R.
Data de Publicação: 2016
Outros Autores: Afonso, Carlos, Castro, Paula M. L., Tiritan, Maria E.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/23003
Resumo: In recent decades, the occurrence of pharmaceuticals in the environment has been widely reported due to their high frequency and recalcitrance in many cases. Concerning the chiral pharmaceuticals (CPs) in environmental matrices, the stereochemistry is often neglected and enantiomers are determined together as unique molecules. However, it is well known that CPs might have enantioselective toxicity, rendering important to assess the occurrence and degradation processes of single enantiomers in the environment, namely during biological treatment in wastewater treatment plants (WWTPs). The development of analytical methods to qualitatively and quantitatively evaluate the enantiomers of CPs is crucial for determining enantiomeric fraction (EF). The EF is the most important parameter in studies involving enantiomers and enantioselective processes and fundamental in biodegradation studies and wastewater monitoring. This review summarizes the analytical methods used to determine EF of CPs in environmental matrices and/or during biodegradation processes. The occurrence of CPs in the environment and their biodegradation are reviewed and future trends in the area outlined.
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spelling Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidadeChiral pharmaceuticals in diverse environmental matrices: Occurrence, removal and toxicityChiral pharmaceuticalsEnantioselectivityEnvironmentIn recent decades, the occurrence of pharmaceuticals in the environment has been widely reported due to their high frequency and recalcitrance in many cases. Concerning the chiral pharmaceuticals (CPs) in environmental matrices, the stereochemistry is often neglected and enantiomers are determined together as unique molecules. However, it is well known that CPs might have enantioselective toxicity, rendering important to assess the occurrence and degradation processes of single enantiomers in the environment, namely during biological treatment in wastewater treatment plants (WWTPs). The development of analytical methods to qualitatively and quantitatively evaluate the enantiomers of CPs is crucial for determining enantiomeric fraction (EF). The EF is the most important parameter in studies involving enantiomers and enantioselective processes and fundamental in biodegradation studies and wastewater monitoring. This review summarizes the analytical methods used to determine EF of CPs in environmental matrices and/or during biodegradation processes. The occurrence of CPs in the environment and their biodegradation are reviewed and future trends in the area outlined.Veritati - Repositório Institucional da Universidade Católica PortuguesaRibeiro, Ana R.Afonso, CarlosCastro, Paula M. L.Tiritan, Maria E.2017-10-12T10:13:19Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/23003porRIBEIRO, Ana R.; AFONSO, Carlos; CASTRO, Paula M. L.; TIRITAN, Maria E. - Chiral pharmaceuticals in diverse environmental matrices: Occurrence, removal and toxicity. Quimica Nova. ISSN 1678-7064. Vol. 39, n.º 5 (2016), p. 598-60710.5935/0100-4042.2016006084978394332000380837200011info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-05T01:35:22Zoai:repositorio.ucp.pt:10400.14/23003Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:17:24.468372Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
Chiral pharmaceuticals in diverse environmental matrices: Occurrence, removal and toxicity
title Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
spellingShingle Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
Ribeiro, Ana R.
Chiral pharmaceuticals
Enantioselectivity
Environment
title_short Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
title_full Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
title_fullStr Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
title_full_unstemmed Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
title_sort Fármacos quirais em diferentes matrizes ambientais: ocorrência, remoção e toxicidade
author Ribeiro, Ana R.
author_facet Ribeiro, Ana R.
Afonso, Carlos
Castro, Paula M. L.
Tiritan, Maria E.
author_role author
author2 Afonso, Carlos
Castro, Paula M. L.
Tiritan, Maria E.
author2_role author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Ribeiro, Ana R.
Afonso, Carlos
Castro, Paula M. L.
Tiritan, Maria E.
dc.subject.por.fl_str_mv Chiral pharmaceuticals
Enantioselectivity
Environment
topic Chiral pharmaceuticals
Enantioselectivity
Environment
description In recent decades, the occurrence of pharmaceuticals in the environment has been widely reported due to their high frequency and recalcitrance in many cases. Concerning the chiral pharmaceuticals (CPs) in environmental matrices, the stereochemistry is often neglected and enantiomers are determined together as unique molecules. However, it is well known that CPs might have enantioselective toxicity, rendering important to assess the occurrence and degradation processes of single enantiomers in the environment, namely during biological treatment in wastewater treatment plants (WWTPs). The development of analytical methods to qualitatively and quantitatively evaluate the enantiomers of CPs is crucial for determining enantiomeric fraction (EF). The EF is the most important parameter in studies involving enantiomers and enantioselective processes and fundamental in biodegradation studies and wastewater monitoring. This review summarizes the analytical methods used to determine EF of CPs in environmental matrices and/or during biodegradation processes. The occurrence of CPs in the environment and their biodegradation are reviewed and future trends in the area outlined.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2017-10-12T10:13:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/23003
url http://hdl.handle.net/10400.14/23003
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv RIBEIRO, Ana R.; AFONSO, Carlos; CASTRO, Paula M. L.; TIRITAN, Maria E. - Chiral pharmaceuticals in diverse environmental matrices: Occurrence, removal and toxicity. Quimica Nova. ISSN 1678-7064. Vol. 39, n.º 5 (2016), p. 598-607
10.5935/0100-4042.20160060
84978394332
000380837200011
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eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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