FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Química Nova (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000500598 |
Resumo: | In recent decades, the occurrence of pharmaceuticals in the environment has been widely reported due to their high frequency and recalcitrance in many cases. Concerning the chiral pharmaceuticals (CPs) in environmental matrices, the stereochemistry is often neglected and enantiomers are determined together as unique molecules. However, it is well known that CPs might have enantioselective toxicity, rendering important to assess the occurrence and degradation processes of single enantiomers in the environment, namely during biological treatment in wastewater treatment plants (WWTPs). The development of analytical methods to qualitatively and quantitatively evaluate the enantiomers of CPs is crucial for determining enantiomeric fraction (EF). The EF is the most important parameter in studies involving enantiomers and enantioselective processes and fundamental in biodegradation studies and wastewater monitoring. This review summarizes the analytical methods used to determine EF of CPs in environmental matrices and/or during biodegradation processes. The occurrence of CPs in the environment and their biodegradation are reviewed and future trends in the area outlined. |
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FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADEchiral pharmaceuticalsenantioselectivityenvironmentIn recent decades, the occurrence of pharmaceuticals in the environment has been widely reported due to their high frequency and recalcitrance in many cases. Concerning the chiral pharmaceuticals (CPs) in environmental matrices, the stereochemistry is often neglected and enantiomers are determined together as unique molecules. However, it is well known that CPs might have enantioselective toxicity, rendering important to assess the occurrence and degradation processes of single enantiomers in the environment, namely during biological treatment in wastewater treatment plants (WWTPs). The development of analytical methods to qualitatively and quantitatively evaluate the enantiomers of CPs is crucial for determining enantiomeric fraction (EF). The EF is the most important parameter in studies involving enantiomers and enantioselective processes and fundamental in biodegradation studies and wastewater monitoring. This review summarizes the analytical methods used to determine EF of CPs in environmental matrices and/or during biodegradation processes. The occurrence of CPs in the environment and their biodegradation are reviewed and future trends in the area outlined.Sociedade Brasileira de Química2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000500598Química Nova v.39 n.5 2016reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20160060info:eu-repo/semantics/openAccessRibeiro,Ana R.Afonso,CarlosCastro,Paula M. L.Tiritan,Maria E.por2016-07-07T00:00:00Zoai:scielo:S0100-40422016000500598Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2016-07-07T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE |
title |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE |
spellingShingle |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE Ribeiro,Ana R. chiral pharmaceuticals enantioselectivity environment |
title_short |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE |
title_full |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE |
title_fullStr |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE |
title_full_unstemmed |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE |
title_sort |
FÁRMACOS QUIRAIS EM DIFERENTES MATRIZES AMBIENTAIS: OCORRÊNCIA, REMOÇÃO E TOXICIDADE |
author |
Ribeiro,Ana R. |
author_facet |
Ribeiro,Ana R. Afonso,Carlos Castro,Paula M. L. Tiritan,Maria E. |
author_role |
author |
author2 |
Afonso,Carlos Castro,Paula M. L. Tiritan,Maria E. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Ribeiro,Ana R. Afonso,Carlos Castro,Paula M. L. Tiritan,Maria E. |
dc.subject.por.fl_str_mv |
chiral pharmaceuticals enantioselectivity environment |
topic |
chiral pharmaceuticals enantioselectivity environment |
description |
In recent decades, the occurrence of pharmaceuticals in the environment has been widely reported due to their high frequency and recalcitrance in many cases. Concerning the chiral pharmaceuticals (CPs) in environmental matrices, the stereochemistry is often neglected and enantiomers are determined together as unique molecules. However, it is well known that CPs might have enantioselective toxicity, rendering important to assess the occurrence and degradation processes of single enantiomers in the environment, namely during biological treatment in wastewater treatment plants (WWTPs). The development of analytical methods to qualitatively and quantitatively evaluate the enantiomers of CPs is crucial for determining enantiomeric fraction (EF). The EF is the most important parameter in studies involving enantiomers and enantioselective processes and fundamental in biodegradation studies and wastewater monitoring. This review summarizes the analytical methods used to determine EF of CPs in environmental matrices and/or during biodegradation processes. The occurrence of CPs in the environment and their biodegradation are reviewed and future trends in the area outlined. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000500598 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000500598 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
10.5935/0100-4042.20160060 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Química Nova v.39 n.5 2016 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Química Nova (Online) |
collection |
Química Nova (Online) |
repository.name.fl_str_mv |
Química Nova (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
quimicanova@sbq.org.br |
_version_ |
1750318117525913600 |