Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100003 |
Resumo: | Five solid membrane sensors responsive to memantine hydrochloride (MEM) and pramipexole dihydrochloride monohydrate (PXL) are described for simple and fast determination of these drugs in pharmaceutical preparation and human plasma. The first and the second sensors are based on the formation of an ion association complex between MEM as a cationic drug with Na tetra phenyl borate and ammonium reineckate (as anionic exchanger), respectively. The third sensor is based on the formation of an ion association complex between PXL with ammonium reineckate. The produced electroactive material is dispersed in PVC matrix. While the other fourth and fifth sensors are based on using functionalized lipophilic cyclodextrin derivative (2-hydroxypropyl-β-cyclodextrin) as sensor ionophore for the determination of MEM and PXL. The performance characteristics of these sensors-evaluated according to IUPAC recommendations-reveal fast, stable and near Nernstian response for 1 \D7 10-4 - 1 \D7 10-1 M and 1 \D7 10-6 - 1 \D7 10-2 M for (MEM) and (PXL), respectively. Many inorganic and organic substances such as drug excipients and diluents normally used in drug formulations do not interfere with drugs response. Statistical comparison between the results obtained by applying the proposed potentiometric method for the determination of the (MEM) and (PXL) in their pure powder forms and those obtained by applying the reported methods was done and no significant difference was found at p = 0.05. Validation of the method according to ICH guidelines shows the suitability of the sensors for quality control analysis of the cited drugs in pharmaceutical formulations and human plasma. The proposed sensors can also be used as a detector for HPLC. |
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Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydratememantine hydrochloridepramipexol dihdydrochloridemembrane sensorspotentiometryFive solid membrane sensors responsive to memantine hydrochloride (MEM) and pramipexole dihydrochloride monohydrate (PXL) are described for simple and fast determination of these drugs in pharmaceutical preparation and human plasma. The first and the second sensors are based on the formation of an ion association complex between MEM as a cationic drug with Na tetra phenyl borate and ammonium reineckate (as anionic exchanger), respectively. The third sensor is based on the formation of an ion association complex between PXL with ammonium reineckate. The produced electroactive material is dispersed in PVC matrix. While the other fourth and fifth sensors are based on using functionalized lipophilic cyclodextrin derivative (2-hydroxypropyl-β-cyclodextrin) as sensor ionophore for the determination of MEM and PXL. The performance characteristics of these sensors-evaluated according to IUPAC recommendations-reveal fast, stable and near Nernstian response for 1 \D7 10-4 - 1 \D7 10-1 M and 1 \D7 10-6 - 1 \D7 10-2 M for (MEM) and (PXL), respectively. Many inorganic and organic substances such as drug excipients and diluents normally used in drug formulations do not interfere with drugs response. Statistical comparison between the results obtained by applying the proposed potentiometric method for the determination of the (MEM) and (PXL) in their pure powder forms and those obtained by applying the reported methods was done and no significant difference was found at p = 0.05. Validation of the method according to ICH guidelines shows the suitability of the sensors for quality control analysis of the cited drugs in pharmaceutical formulations and human plasma. The proposed sensors can also be used as a detector for HPLC.Sociedade Portuguesa de Electroquímica2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100003Portugaliae Electrochimica Acta v.30 n.1 2012reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100003Merey,Hanan A.Helmy,Marwa I.Tawakkol,Shereen M.Toubar,Safaa S.Risk,Mohamed S.info:eu-repo/semantics/openAccess2024-02-06T17:07:09Zoai:scielo:S0872-19042012000100003Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:11.824960Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate |
title |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate |
spellingShingle |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate Merey,Hanan A. memantine hydrochloride pramipexol dihdydrochloride membrane sensors potentiometry |
title_short |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate |
title_full |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate |
title_fullStr |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate |
title_full_unstemmed |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate |
title_sort |
Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate |
author |
Merey,Hanan A. |
author_facet |
Merey,Hanan A. Helmy,Marwa I. Tawakkol,Shereen M. Toubar,Safaa S. Risk,Mohamed S. |
author_role |
author |
author2 |
Helmy,Marwa I. Tawakkol,Shereen M. Toubar,Safaa S. Risk,Mohamed S. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Merey,Hanan A. Helmy,Marwa I. Tawakkol,Shereen M. Toubar,Safaa S. Risk,Mohamed S. |
dc.subject.por.fl_str_mv |
memantine hydrochloride pramipexol dihdydrochloride membrane sensors potentiometry |
topic |
memantine hydrochloride pramipexol dihdydrochloride membrane sensors potentiometry |
description |
Five solid membrane sensors responsive to memantine hydrochloride (MEM) and pramipexole dihydrochloride monohydrate (PXL) are described for simple and fast determination of these drugs in pharmaceutical preparation and human plasma. The first and the second sensors are based on the formation of an ion association complex between MEM as a cationic drug with Na tetra phenyl borate and ammonium reineckate (as anionic exchanger), respectively. The third sensor is based on the formation of an ion association complex between PXL with ammonium reineckate. The produced electroactive material is dispersed in PVC matrix. While the other fourth and fifth sensors are based on using functionalized lipophilic cyclodextrin derivative (2-hydroxypropyl-β-cyclodextrin) as sensor ionophore for the determination of MEM and PXL. The performance characteristics of these sensors-evaluated according to IUPAC recommendations-reveal fast, stable and near Nernstian response for 1 \D7 10-4 - 1 \D7 10-1 M and 1 \D7 10-6 - 1 \D7 10-2 M for (MEM) and (PXL), respectively. Many inorganic and organic substances such as drug excipients and diluents normally used in drug formulations do not interfere with drugs response. Statistical comparison between the results obtained by applying the proposed potentiometric method for the determination of the (MEM) and (PXL) in their pure powder forms and those obtained by applying the reported methods was done and no significant difference was found at p = 0.05. Validation of the method according to ICH guidelines shows the suitability of the sensors for quality control analysis of the cited drugs in pharmaceutical formulations and human plasma. The proposed sensors can also be used as a detector for HPLC. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100003 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042012000100003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
dc.source.none.fl_str_mv |
Portugaliae Electrochimica Acta v.30 n.1 2012 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799137290474225664 |