Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes

Detalhes bibliográficos
Autor(a) principal: Issa,Yousry M.
Data de Publicação: 2021
Outros Autores: Khalil,Mohamed M., Zayed,Sayed I. M., Mustafa,Naglaa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042021000500381
Resumo: Abstract Two carbon paste electrodes for oxymetazoline hydrochloride were constructed based on ion pair complexes of this drug, with sodium tetraphenylborate (NaTPB) or ammonium reineckate, using dibutyl phthalate and dioctyl phthalate as solvent mediators, respectively. The developed electrodes displayed a fast, stable response over the concentration range from 3.98x10-5 to 1x10-2 M oxymetazoline hydrochloride, with a near-nernstian slope of 59.0, 58.2 mV of concentration decade-1 and a limit of detection (LOD) of 3.31x10-5 and 3.72x10-5 M, in the oxymetazoline-tetraphenylborate and oxymetazoline-reineckate cases, respectively. The developed electrodes have been successfully applied for oxymetazoline hydrochloride determination in the Afrin nasal drop pharmaceutical formulation.
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spelling Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste ElectrodesOxymetazoline hydrochloridemodified carbon paste electrodepotentiometrypharmaceutical formulationAbstract Two carbon paste electrodes for oxymetazoline hydrochloride were constructed based on ion pair complexes of this drug, with sodium tetraphenylborate (NaTPB) or ammonium reineckate, using dibutyl phthalate and dioctyl phthalate as solvent mediators, respectively. The developed electrodes displayed a fast, stable response over the concentration range from 3.98x10-5 to 1x10-2 M oxymetazoline hydrochloride, with a near-nernstian slope of 59.0, 58.2 mV of concentration decade-1 and a limit of detection (LOD) of 3.31x10-5 and 3.72x10-5 M, in the oxymetazoline-tetraphenylborate and oxymetazoline-reineckate cases, respectively. The developed electrodes have been successfully applied for oxymetazoline hydrochloride determination in the Afrin nasal drop pharmaceutical formulation.Sociedade Portuguesa de Electroquímica2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042021000500381Portugaliae Electrochimica Acta v.39 n.5 2021reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042021000500381Issa,Yousry M.Khalil,Mohamed M.Zayed,Sayed I. M.Mustafa,Naglaainfo:eu-repo/semantics/openAccess2024-02-06T17:07:36Zoai:scielo:S0872-19042021000500381Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:28.164006Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
title Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
spellingShingle Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
Issa,Yousry M.
Oxymetazoline hydrochloride
modified carbon paste electrode
potentiometry
pharmaceutical formulation
title_short Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
title_full Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
title_fullStr Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
title_full_unstemmed Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
title_sort Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes
author Issa,Yousry M.
author_facet Issa,Yousry M.
Khalil,Mohamed M.
Zayed,Sayed I. M.
Mustafa,Naglaa
author_role author
author2 Khalil,Mohamed M.
Zayed,Sayed I. M.
Mustafa,Naglaa
author2_role author
author
author
dc.contributor.author.fl_str_mv Issa,Yousry M.
Khalil,Mohamed M.
Zayed,Sayed I. M.
Mustafa,Naglaa
dc.subject.por.fl_str_mv Oxymetazoline hydrochloride
modified carbon paste electrode
potentiometry
pharmaceutical formulation
topic Oxymetazoline hydrochloride
modified carbon paste electrode
potentiometry
pharmaceutical formulation
description Abstract Two carbon paste electrodes for oxymetazoline hydrochloride were constructed based on ion pair complexes of this drug, with sodium tetraphenylborate (NaTPB) or ammonium reineckate, using dibutyl phthalate and dioctyl phthalate as solvent mediators, respectively. The developed electrodes displayed a fast, stable response over the concentration range from 3.98x10-5 to 1x10-2 M oxymetazoline hydrochloride, with a near-nernstian slope of 59.0, 58.2 mV of concentration decade-1 and a limit of detection (LOD) of 3.31x10-5 and 3.72x10-5 M, in the oxymetazoline-tetraphenylborate and oxymetazoline-reineckate cases, respectively. The developed electrodes have been successfully applied for oxymetazoline hydrochloride determination in the Afrin nasal drop pharmaceutical formulation.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042021000500381
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042021000500381
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042021000500381
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
publisher.none.fl_str_mv Sociedade Portuguesa de Electroquímica
dc.source.none.fl_str_mv Portugaliae Electrochimica Acta v.39 n.5 2021
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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