Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/56653 |
| Resumo: | © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| id |
RCAP_b8bd3cee53e30a6c0ad756f631530d7b |
|---|---|
| oai_identifier_str |
oai:repositorio.ul.pt:10451/56653 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathwayAspergillus fumigatusRab11Rab7Annexin A2ExocytosisHeat shock proteinHuman p11Invasive aspergillosisPhagosome maturationRecycling endosome© 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).The decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. We discovered that human p11 is a critical factor for this decision. The HscA protein present on the conidial surface of the human-pathogenic fungus Aspergillus fumigatus anchors p11 on conidia-containing phagosomes (PSs), excludes the PS maturation mediator Rab7, and triggers binding of exocytosis mediators Rab11 and Sec15. This reprogramming redirects PSs to the non-degradative pathway, allowing A. fumigatus to escape cells by outgrowth and expulsion as well as transfer of conidia between cells. The clinical relevance is supported by the identification of a single nucleotide polymorphism in the non-coding region of the S100A10 (p11) gene that affects mRNA and protein expression in response to A. fumigatus and is associated with protection against invasive pulmonary aspergillosis. These findings reveal the role of p11 in mediating fungal PS evasion.This work was funded by the Deutsche Forschungsgemeinschaft (DFG) cluster of excellence Balance of the Microverse (Project-ID 390713860, Gepris 2051), the DFG-ANR project “AfuInf (316898429),” DFG CRC/Transregio 124 “FungiNet” (A1, Z2; 210879364), DFG CRC 1278 “PolyTarget” (Z01; 316213987), Leibniz project (K217/2016), Fundação para a Ciência e a Tecnologia (FCT) (PTDC/MED-OUT/1112/2021, UIDB/50026/2020, UIDP/50026/2020, NORTE-01-0145-FEDER-000039), EU’s Horizon 2020 (847507), “la Caixa” Foundation (ID 100010434) and FCT (LCF/PR/HR17/52190003), Gilead Research Scholars Program - Anti-Fungals, and EU-funded Horizon 2020 project HDM-FUN (ID 847507). M.R. and F.S. were supported by the DFG excellence graduate school Jena School for Microbial Communication, and C.C. by FCT (CEECIND/04058/2018).ElsevierRepositório da Universidade de LisboaJia, Lei-JieRafiq, MuhammadRadosa, LukášHortschansky, PeterCunha, CristinaCseresnyés, ZoltánKrüger, ThomasSchmidt, FranziskaHeinekamp, ThorstenStraßburger, MariaLöffler, BettinaDoenst, TorstenLacerda, JoãoCampos, AntónioFigge, Marc ThiloCarvalho, AgostinhoKniemeyer, OlafBrakhage, Axel A.2023-03-14T14:09:14Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56653engCell Host Microbe. 2023 Mar 8;31(3):373-388.e101931-312810.1016/j.chom.2023.02.0021934-6069info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:20:10Zoai:repositorio.ul.pt:10451/56653Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:20:10Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway |
| title |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway |
| spellingShingle |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway Jia, Lei-Jie Aspergillus fumigatus Rab11 Rab7 Annexin A2 Exocytosis Heat shock protein Human p11 Invasive aspergillosis Phagosome maturation Recycling endosome |
| title_short |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway |
| title_full |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway |
| title_fullStr |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway |
| title_full_unstemmed |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway |
| title_sort |
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway |
| author |
Jia, Lei-Jie |
| author_facet |
Jia, Lei-Jie Rafiq, Muhammad Radosa, Lukáš Hortschansky, Peter Cunha, Cristina Cseresnyés, Zoltán Krüger, Thomas Schmidt, Franziska Heinekamp, Thorsten Straßburger, Maria Löffler, Bettina Doenst, Torsten Lacerda, João Campos, António Figge, Marc Thilo Carvalho, Agostinho Kniemeyer, Olaf Brakhage, Axel A. |
| author_role |
author |
| author2 |
Rafiq, Muhammad Radosa, Lukáš Hortschansky, Peter Cunha, Cristina Cseresnyés, Zoltán Krüger, Thomas Schmidt, Franziska Heinekamp, Thorsten Straßburger, Maria Löffler, Bettina Doenst, Torsten Lacerda, João Campos, António Figge, Marc Thilo Carvalho, Agostinho Kniemeyer, Olaf Brakhage, Axel A. |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Jia, Lei-Jie Rafiq, Muhammad Radosa, Lukáš Hortschansky, Peter Cunha, Cristina Cseresnyés, Zoltán Krüger, Thomas Schmidt, Franziska Heinekamp, Thorsten Straßburger, Maria Löffler, Bettina Doenst, Torsten Lacerda, João Campos, António Figge, Marc Thilo Carvalho, Agostinho Kniemeyer, Olaf Brakhage, Axel A. |
| dc.subject.por.fl_str_mv |
Aspergillus fumigatus Rab11 Rab7 Annexin A2 Exocytosis Heat shock protein Human p11 Invasive aspergillosis Phagosome maturation Recycling endosome |
| topic |
Aspergillus fumigatus Rab11 Rab7 Annexin A2 Exocytosis Heat shock protein Human p11 Invasive aspergillosis Phagosome maturation Recycling endosome |
| description |
© 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-03-14T14:09:14Z 2023 2023-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/56653 |
| url |
http://hdl.handle.net/10451/56653 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Cell Host Microbe. 2023 Mar 8;31(3):373-388.e10 1931-3128 10.1016/j.chom.2023.02.002 1934-6069 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
| _version_ |
1817549225527869440 |
