Nanocarrier-mediated topical insulin delivery for wound healing
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/16898 |
Resumo: | Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers. |
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Nanocarrier-mediated topical insulin delivery for wound healingInsulinWound healinNanomedicineTopical deliverWoundsBurnsPolymer nanoparticleLipid nanoparticleInorganic nanoparticleWound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers.FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization(POCI) POCI-01-0145-FEDER-032610, PTDC/MEC-DER/32610/2017, UIDB/50006/2020, UIDB/04326/2020, UIDB/04565/2020MDPISapientiaMacedo, Ana S.Mendes, FranciscaFilipe, PatríciaReis, SaletteFonte, Pedro2021-08-25T13:08:24Z2021-07-302021-08-06T15:18:59Z2021-07-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/16898engMaterials 14 (15): 4257 (2021)1996-194410.3390/ma14154257info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:28:53Zoai:sapientia.ualg.pt:10400.1/16898Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:06:55.090526Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nanocarrier-mediated topical insulin delivery for wound healing |
title |
Nanocarrier-mediated topical insulin delivery for wound healing |
spellingShingle |
Nanocarrier-mediated topical insulin delivery for wound healing Macedo, Ana S. Insulin Wound healin Nanomedicine Topical deliver Wounds Burns Polymer nanoparticle Lipid nanoparticle Inorganic nanoparticle |
title_short |
Nanocarrier-mediated topical insulin delivery for wound healing |
title_full |
Nanocarrier-mediated topical insulin delivery for wound healing |
title_fullStr |
Nanocarrier-mediated topical insulin delivery for wound healing |
title_full_unstemmed |
Nanocarrier-mediated topical insulin delivery for wound healing |
title_sort |
Nanocarrier-mediated topical insulin delivery for wound healing |
author |
Macedo, Ana S. |
author_facet |
Macedo, Ana S. Mendes, Francisca Filipe, Patrícia Reis, Salette Fonte, Pedro |
author_role |
author |
author2 |
Mendes, Francisca Filipe, Patrícia Reis, Salette Fonte, Pedro |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Macedo, Ana S. Mendes, Francisca Filipe, Patrícia Reis, Salette Fonte, Pedro |
dc.subject.por.fl_str_mv |
Insulin Wound healin Nanomedicine Topical deliver Wounds Burns Polymer nanoparticle Lipid nanoparticle Inorganic nanoparticle |
topic |
Insulin Wound healin Nanomedicine Topical deliver Wounds Burns Polymer nanoparticle Lipid nanoparticle Inorganic nanoparticle |
description |
Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-25T13:08:24Z 2021-07-30 2021-08-06T15:18:59Z 2021-07-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/16898 |
url |
http://hdl.handle.net/10400.1/16898 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials 14 (15): 4257 (2021) 1996-1944 10.3390/ma14154257 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133313065025536 |