Nanocarrier-mediated topical insulin delivery for wound healing

Detalhes bibliográficos
Autor(a) principal: Macedo, Ana S.
Data de Publicação: 2021
Outros Autores: Mendes, Francisca, Filipe, Patrícia, Reis, Salette, Fonte, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/16898
Resumo: Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers.
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spelling Nanocarrier-mediated topical insulin delivery for wound healingInsulinWound healinNanomedicineTopical deliverWoundsBurnsPolymer nanoparticleLipid nanoparticleInorganic nanoparticleWound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers.FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operational Programme for Competitiveness and Internationalization(POCI) POCI-01-0145-FEDER-032610, PTDC/MEC-DER/32610/2017, UIDB/50006/2020, UIDB/04326/2020, UIDB/04565/2020MDPISapientiaMacedo, Ana S.Mendes, FranciscaFilipe, PatríciaReis, SaletteFonte, Pedro2021-08-25T13:08:24Z2021-07-302021-08-06T15:18:59Z2021-07-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/16898engMaterials 14 (15): 4257 (2021)1996-194410.3390/ma14154257info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:28:53Zoai:sapientia.ualg.pt:10400.1/16898Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:06:55.090526Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanocarrier-mediated topical insulin delivery for wound healing
title Nanocarrier-mediated topical insulin delivery for wound healing
spellingShingle Nanocarrier-mediated topical insulin delivery for wound healing
Macedo, Ana S.
Insulin
Wound healin
Nanomedicine
Topical deliver
Wounds
Burns
Polymer nanoparticle
Lipid nanoparticle
Inorganic nanoparticle
title_short Nanocarrier-mediated topical insulin delivery for wound healing
title_full Nanocarrier-mediated topical insulin delivery for wound healing
title_fullStr Nanocarrier-mediated topical insulin delivery for wound healing
title_full_unstemmed Nanocarrier-mediated topical insulin delivery for wound healing
title_sort Nanocarrier-mediated topical insulin delivery for wound healing
author Macedo, Ana S.
author_facet Macedo, Ana S.
Mendes, Francisca
Filipe, Patrícia
Reis, Salette
Fonte, Pedro
author_role author
author2 Mendes, Francisca
Filipe, Patrícia
Reis, Salette
Fonte, Pedro
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Macedo, Ana S.
Mendes, Francisca
Filipe, Patrícia
Reis, Salette
Fonte, Pedro
dc.subject.por.fl_str_mv Insulin
Wound healin
Nanomedicine
Topical deliver
Wounds
Burns
Polymer nanoparticle
Lipid nanoparticle
Inorganic nanoparticle
topic Insulin
Wound healin
Nanomedicine
Topical deliver
Wounds
Burns
Polymer nanoparticle
Lipid nanoparticle
Inorganic nanoparticle
description Wound care has been clinically demanding due to inefficacious treatment that represents an economic burden for healthcare systems. In Europe, approximately 7 million people are diagnosed with untreated wounds, leading to a cost between 6.000€ and 10.000€ per patient/year. In the United States of America, 1.5 million people over 65 years old suffer from chronic wounds. A promising therapeutic strategy is the use of exogenous growth factors because they are decreased at the wound site, limiting the recovery of the skin. Insulin is one of the cheapest growth factors in the market able to accelerate the re-epithelialization and stimulate angiogenesis and cell migration. However, the effectiveness of topical insulin in wound healing is hampered by the proteases in the wound bed. The encapsulation into nanoparticles improves its stability in the wound, providing adhesion to the mucosal surface and allowing its sustained release. The aim of this review is to perform a standing point about a promising strategy to treat different types of wounds by the topical delivery of insulin-loaded nanocarriers.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-25T13:08:24Z
2021-07-30
2021-08-06T15:18:59Z
2021-07-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/16898
url http://hdl.handle.net/10400.1/16898
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials 14 (15): 4257 (2021)
1996-1944
10.3390/ma14154257
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eu_rights_str_mv openAccess
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publisher.none.fl_str_mv MDPI
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instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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