The bounds of education in the human brain connectome

Detalhes bibliográficos
Autor(a) principal: Marques, Paulo César Gonçalves
Data de Publicação: 2015
Outros Autores: Soares, José Miguel Montenegro, Magalhaes, Ricardo José da Silva, Santos, Nadine Correia, Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/40679
Resumo: Inter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite effect on the long-term. These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.
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spelling The bounds of education in the human brain connectomeCiências Médicas::Ciências da SaúdeScience & TechnologyInter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite effect on the long-term. These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.This work was funded by the European Commission (FP7): “SwitchBox” (Contract HEALTH-F2-2010-259772) and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). José M. Soares, Paulo Marques, and Nadine C. Santos are supported by fellowships of the project “SwitchBox”; Ricardo Magalhães is supported by a fellowship from the project FCT ANR/NEU-OSD/0258/2012 funded by FCT/MEC (www.fct.pt) and by ON.2 – ONOVONORTE – North Portugal Regional Operational Programme 2007/2013, of the National Strategic Reference Framework (NSRF) 2007/2013, through FEDER.Nature Publishing GroupUniversidade do MinhoMarques, Paulo César GonçalvesSoares, José Miguel MontenegroMagalhaes, Ricardo José da SilvaSantos, Nadine CorreiaSousa, Nuno20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/40679engMarques, P., Soares, J. M., Magalhaes, R., Santos, N. C., & Sousa, N. (2015). The Bounds of Education In The Human Brain Connectome. Scientific Reports, 5. doi: 10.1038/srep128122045-232210.1038/srep1281226245669http://www.nature.cominfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:45:44Zoai:repositorium.sdum.uminho.pt:1822/40679Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:43:38.215496Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The bounds of education in the human brain connectome
title The bounds of education in the human brain connectome
spellingShingle The bounds of education in the human brain connectome
Marques, Paulo César Gonçalves
Ciências Médicas::Ciências da Saúde
Science & Technology
title_short The bounds of education in the human brain connectome
title_full The bounds of education in the human brain connectome
title_fullStr The bounds of education in the human brain connectome
title_full_unstemmed The bounds of education in the human brain connectome
title_sort The bounds of education in the human brain connectome
author Marques, Paulo César Gonçalves
author_facet Marques, Paulo César Gonçalves
Soares, José Miguel Montenegro
Magalhaes, Ricardo José da Silva
Santos, Nadine Correia
Sousa, Nuno
author_role author
author2 Soares, José Miguel Montenegro
Magalhaes, Ricardo José da Silva
Santos, Nadine Correia
Sousa, Nuno
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Marques, Paulo César Gonçalves
Soares, José Miguel Montenegro
Magalhaes, Ricardo José da Silva
Santos, Nadine Correia
Sousa, Nuno
dc.subject.por.fl_str_mv Ciências Médicas::Ciências da Saúde
Science & Technology
topic Ciências Médicas::Ciências da Saúde
Science & Technology
description Inter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite effect on the long-term. These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/40679
url http://hdl.handle.net/1822/40679
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marques, P., Soares, J. M., Magalhaes, R., Santos, N. C., & Sousa, N. (2015). The Bounds of Education In The Human Brain Connectome. Scientific Reports, 5. doi: 10.1038/srep12812
2045-2322
10.1038/srep12812
26245669
http://www.nature.com
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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