One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia
| Autor(a) principal: | |
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| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/52995 |
Resumo: | This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
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One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast AsiaThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.Background: In 2015, Singapore had the first and only reported foodborne outbreak of invasive disease caused by the group B Streptococcus (GBS; Streptococcus agalactiae). Disease, predominantly septic arthritis and meningitis, was associated with sequence type (ST)283, acquired from eating raw farmed freshwater fish. Although GBS sepsis is well-described in neonates and older adults with co-morbidities, this outbreak affected non-pregnant and younger adults with fewer co-morbidities, suggesting greater virulence. Before 2015 ST283 had only been reported from twenty humans in Hong Kong and two in France, and from one fish in Thailand. We hypothesised that ST283 was causing region-wide infection in Southeast Asia. Methodology/principal findings: We performed a literature review, whole genome sequencing on 145 GBS isolates collected from six Southeast Asian countries, and phylogenetic analysis on 7,468 GBS sequences including 227 variants of ST283 from humans and animals. Although almost absent outside Asia, ST283 was found in all invasive Asian collections analysed, from 1995 to 2017. It accounted for 29/38 (76%) human isolates in Lao PDR, 102/139 (73%) in Thailand, 4/13 (31%) in Vietnam, and 167/739 (23%) in Singapore. ST283 and its variants were found in 62/62 (100%) tilapia from 14 outbreak sites in Malaysia and Vietnam, in seven fish species in Singapore markets, and a diseased frog in China. Conclusions: GBS ST283 is widespread in Southeast Asia, where it accounts for a large proportion of bacteraemic GBS, and causes disease and economic loss in aquaculture. If human ST283 is fishborne, as in the Singapore outbreak, then GBS sepsis in Thailand and Lao PDR is predominantly a foodborne disease. However, whether transmission is from aquaculture to humans, or vice versa, or involves an unidentified reservoir remains unknown. Creation of cross-border collaborations in human and animal health are needed to complete the epidemiological picture.Support for this project was provided by the Molecular Biology Laboratory and the Department of Laboratory Medicine, Tan Tock Seng Hospital; by the Environmental Health Institute, National Environment Agency, Singapore; by the Ministry of Health, Singapore, through the Singapore Infectious Diseases Initiative grant number SIDI/2016/002 (TB) https://www.moh.gov.sg, and the National Medical Research Council, Ministry of Health, Singapore grant number NMRC/CIRG/1467/2017 (SLC) http://www.nmrc.gov.sg, by the UK Global Challenges Research Fund via the Scottish Funding Council, SFC/AN/10/2018 (RNZ) http://www.sfc.ac.uk, and by the Global Disease Detection program of the U.S. Centers for Disease Control and Prevention.PLoSRepositório da Universidade de LisboaBarkham, TimothyZadoks, Ruth N.Azmai, Mohammad Noor AmalBaker, StephenBich, Vu Thi NgocChalker, VictoriaChau, Man LingDance, DavidDeepak, Rama Narayanavan Doorn, H. RogierGutierrez, Ramona A.Holmes, Mark A.Huong, Lan Nguyen PhuKoh, Tse HsienMartins, Elisabete R.Mehershahi, KuroshNewton, PaulNg, Lee ChingPhuoc, Nguyen NgocSangwichian, OrnumaSawatwong, PongpunSurin, UraiwanTan, Thean YenTang, Wen YingThuy, Nguyen VuTurner, PaulVongsouvath, ManivanhZhang, DefengWhistler, ToniChen, Swaine L.2022-05-13T15:29:46Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/52995engPLoS Negl Trop Dis. 2019 Jun 27;13(6):e00074211935-272710.1371/journal.pntd.00074211935-2735info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:30Zoai:repositorio.ul.pt:10451/52995Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:03:58.692836Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia |
| title |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia |
| spellingShingle |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia Barkham, Timothy |
| title_short |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia |
| title_full |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia |
| title_fullStr |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia |
| title_full_unstemmed |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia |
| title_sort |
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia |
| author |
Barkham, Timothy |
| author_facet |
Barkham, Timothy Zadoks, Ruth N. Azmai, Mohammad Noor Amal Baker, Stephen Bich, Vu Thi Ngoc Chalker, Victoria Chau, Man Ling Dance, David Deepak, Rama Narayana van Doorn, H. Rogier Gutierrez, Ramona A. Holmes, Mark A. Huong, Lan Nguyen Phu Koh, Tse Hsien Martins, Elisabete R. Mehershahi, Kurosh Newton, Paul Ng, Lee Ching Phuoc, Nguyen Ngoc Sangwichian, Ornuma Sawatwong, Pongpun Surin, Uraiwan Tan, Thean Yen Tang, Wen Ying Thuy, Nguyen Vu Turner, Paul Vongsouvath, Manivanh Zhang, Defeng Whistler, Toni Chen, Swaine L. |
| author_role |
author |
| author2 |
Zadoks, Ruth N. Azmai, Mohammad Noor Amal Baker, Stephen Bich, Vu Thi Ngoc Chalker, Victoria Chau, Man Ling Dance, David Deepak, Rama Narayana van Doorn, H. Rogier Gutierrez, Ramona A. Holmes, Mark A. Huong, Lan Nguyen Phu Koh, Tse Hsien Martins, Elisabete R. Mehershahi, Kurosh Newton, Paul Ng, Lee Ching Phuoc, Nguyen Ngoc Sangwichian, Ornuma Sawatwong, Pongpun Surin, Uraiwan Tan, Thean Yen Tang, Wen Ying Thuy, Nguyen Vu Turner, Paul Vongsouvath, Manivanh Zhang, Defeng Whistler, Toni Chen, Swaine L. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Barkham, Timothy Zadoks, Ruth N. Azmai, Mohammad Noor Amal Baker, Stephen Bich, Vu Thi Ngoc Chalker, Victoria Chau, Man Ling Dance, David Deepak, Rama Narayana van Doorn, H. Rogier Gutierrez, Ramona A. Holmes, Mark A. Huong, Lan Nguyen Phu Koh, Tse Hsien Martins, Elisabete R. Mehershahi, Kurosh Newton, Paul Ng, Lee Ching Phuoc, Nguyen Ngoc Sangwichian, Ornuma Sawatwong, Pongpun Surin, Uraiwan Tan, Thean Yen Tang, Wen Ying Thuy, Nguyen Vu Turner, Paul Vongsouvath, Manivanh Zhang, Defeng Whistler, Toni Chen, Swaine L. |
| description |
This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2022-05-13T15:29:46Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/52995 |
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http://hdl.handle.net/10451/52995 |
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eng |
| language |
eng |
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PLoS Negl Trop Dis. 2019 Jun 27;13(6):e0007421 1935-2727 10.1371/journal.pntd.0007421 1935-2735 |
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info:eu-repo/semantics/openAccess |
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PLoS |
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PLoS |
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