The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen

Detalhes bibliográficos
Autor(a) principal: Repizo, Guillermo D.
Data de Publicação: 2017
Outros Autores: Viale, Alejandro M., Borges, Vítor, Cameranesi, María M., Taib, Najwa, Espariz, Martín, Brochier-Armanet, Céline, Gomes, João Paulo, Salcedo, Suzana P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5218
Resumo: Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28934377/
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spelling The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial PathogenAcinetobacter baumanniiCRISPRs/casComparative GenomicsPreantibiotic era bacteriumVirulence FactorsInfecções RespiratóriasFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28934377/Acinetobacter baumannii represents nowadays an important nosocomial opportunistic pathogen whose reservoirs outside the clinical setting are obscure. Here, we traced the origins of the collection strain A. baumannii DSM30011 to an isolate first reported in 1944, obtained from the enriched microbiota responsible of the aerobic decomposition of the resinous desert shrub guayule. Whole-genome sequencing and phylogenetic analysis based on core genes confirmed DSM30011 affiliation to A. baumannii. Comparative studies with 32 complete A. baumannii genomes revealed the presence of 12 unique accessory chromosomal regions in DSM30011 including five encompassing phage-related genes, five containing toxin genes of the type-6 secretion system, and one with an atypical CRISPRs/cas cluster. No antimicrobial resistance islands were identified in DSM30011 agreeing with a general antimicrobial susceptibility phenotype including folate synthesis inhibitors. The marginal ampicillin resistance of DSM30011 most likely derived from chromosomal ADC-type ampC and blaOXA-51-type genes. Searching for catabolic pathways genes revealed several clusters involved in the degradation of plant defenses including woody tissues and a previously unreported atu locus responsible of aliphatic terpenes degradation, thus suggesting that resinous plants may provide an effective niche for this organism. DSM30011 also harbored most genes and regulatory mechanisms linked to persistence and virulence in pathogenic Acinetobacter species. This strain thus revealed important clues into the genomic diversity, virulence potential, and niche ranges of the preantibiotic era A. baumannii population, and may provide an useful tool for our understanding of the processes that led to the recent evolution of this species toward an opportunistic pathogen of humans.This work was supported by a FINOVI Young Researcher Grant awarded to S.P.S.; by an Investissement d’Avenir (ANR-10-BINF-01-01) grant awarded to C.B.-A., and from grants to A.M.V. from the Agencia Nacional de Promocion Cientíıfica y Tecnologica (ANPCyT); Consejo Nacional de Investigaciones Cientıficas y Técnicas (CONICET-PIP1055); Ministerio de Ciencia, Tecnologıa e Innovacion Productiva, Provincia de Santa Fe; Argentina. A.M.V., G.D.R., and M.E. are staff members of CONICET. C.B.-A. is member of the Institut Universitaire de France.Oxford University Press/Society for Molecular Biology and EvolutionRepositório Científico do Instituto Nacional de SaúdeRepizo, Guillermo D.Viale, Alejandro M.Borges, VítorCameranesi, María M.Taib, NajwaEspariz, MartínBrochier-Armanet, CélineGomes, João PauloSalcedo, Suzana P.2018-03-06T15:54:52Z2017-09-012017-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5218engGenome Biol Evol. 2017 Sep 1;9(9):2292-2307. doi: 10.1093/gbe/evx162.1759-6653 (online)10.1093/gbe/evx162info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:44Zoai:repositorio.insa.pt:10400.18/5218Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:56.023590Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
title The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
spellingShingle The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
Repizo, Guillermo D.
Acinetobacter baumannii
CRISPRs/cas
Comparative Genomics
Preantibiotic era bacterium
Virulence Factors
Infecções Respiratórias
title_short The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
title_full The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
title_fullStr The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
title_full_unstemmed The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
title_sort The Environmental Acinetobacter baumannii Isolate DSM30011 Reveals Clues into the Preantibiotic Era Genome Diversity, Virulence Potential, and Niche Range of a Predominant Nosocomial Pathogen
author Repizo, Guillermo D.
author_facet Repizo, Guillermo D.
Viale, Alejandro M.
Borges, Vítor
Cameranesi, María M.
Taib, Najwa
Espariz, Martín
Brochier-Armanet, Céline
Gomes, João Paulo
Salcedo, Suzana P.
author_role author
author2 Viale, Alejandro M.
Borges, Vítor
Cameranesi, María M.
Taib, Najwa
Espariz, Martín
Brochier-Armanet, Céline
Gomes, João Paulo
Salcedo, Suzana P.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Repizo, Guillermo D.
Viale, Alejandro M.
Borges, Vítor
Cameranesi, María M.
Taib, Najwa
Espariz, Martín
Brochier-Armanet, Céline
Gomes, João Paulo
Salcedo, Suzana P.
dc.subject.por.fl_str_mv Acinetobacter baumannii
CRISPRs/cas
Comparative Genomics
Preantibiotic era bacterium
Virulence Factors
Infecções Respiratórias
topic Acinetobacter baumannii
CRISPRs/cas
Comparative Genomics
Preantibiotic era bacterium
Virulence Factors
Infecções Respiratórias
description Free PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28934377/
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
2017-09-01T00:00:00Z
2018-03-06T15:54:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5218
url http://hdl.handle.net/10400.18/5218
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genome Biol Evol. 2017 Sep 1;9(9):2292-2307. doi: 10.1093/gbe/evx162.
1759-6653 (online)
10.1093/gbe/evx162
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press/Society for Molecular Biology and Evolution
publisher.none.fl_str_mv Oxford University Press/Society for Molecular Biology and Evolution
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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