European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease?
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/56662 |
Resumo: | © 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease?Non-alcoholic fatty liver diseaseLiver healthMultiple joint correspondence analysisPolicy preparednessHealth policyMetabolic-associated fatty liver diseaseNon-alcoholic steatohepatitisEurope© 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Background & aims: Non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity, metabolic syndrome, and diabetes, is a highly prevalent emerging condition that can be optimally managed through a multidisciplinary patient-centred approach. National preparedness to address NAFLD is essential to ensure that health systems can deliver effective care. We present a NAFLD Preparedness Index for Europe. Methods: In June 2019, data were extracted by expert groups from 29 countries to complete a 41-item questionnaire about NAFLD. Questions were classified into 4 categories: policies/civil society (9 questions), guidelines (16 questions), epidemiology (4 questions), and care management (12 questions). Based on the responses, national preparedness for each indicator was classified into low, middle, or high-levels. We then applied a multiple correspondence analysis to obtain a standardised preparedness score for each country ranging from 0 to 100. Results: The analysis estimated a summary factor that explained 71.3% of the variation in the dataset. No countries were found to have yet attained a high-level of preparedness. Currently, the UK (75.5) scored best, although falling within the mid-level preparedness band, followed by Spain (56.2), and Denmark (43.4), whereas Luxembourg and Ireland were the lowest scoring countries with a score of 4.9. Only Spain scored highly in the epidemiology indicator category, whereas the UK was the only country that scored highly for care management. Conclusions: The NAFLD Preparedness Index indicates substantial variation between countries' readiness to address NAFLD. Notably, even those countries that score relatively highly exhibit deficiencies in key domains, suggesting that structural changes are needed to optimise NAFLD management and ensure effective public health approaches are in place. Lay summary: Non-alcoholic fatty liver disease (NAFLD), which is closely associated with obesity, metabolic syndrome, and diabetes, is a highly prevalent condition that can be optimally managed through a multidisciplinary patient-centred approach. National preparedness to address NAFLD is essential to allow for effective public health measures aimed at preventing disease while also ensuring that health systems can deliver effective care to affected populations. This study defined preparedness as having adequate policies and civil society engagement, guidelines, epidemiology, and care management. NAFLD preparedness was found to be deficient in all 29 countries studied, with great variation among the countries and the 4 categories studied.JVL is supported by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III/ESF, European Union [CP18/00074]) and further acknowledges institutional support from the Spanish Ministry of Science, Innovation and Universities through the ‘Centro de Excelencia Severo Ochoa 2019–2023’ Programme (CEX2018-000806-S), and support from the Government of Catalonia through the CERCA Programme. QMA and VR are members of the EPoS (Elucidating Pathways of Steatohepatitis) consortium funded by the Horizon 2020 Framework Program of the European Union under Grant Agreement 634413. QMA, VR, HCP, ME, and MRG are members of the LITMUS (Liver Investigation: Testing Marker Utility in Steatohepatitis) consortium funded by the IMI2 Program of the European Union under Grant Agreement 777377. QMA is a Newcastle NIHR Biomedical Research Centre investigator.ElsevierRepositório da Universidade de LisboaLazarus, Jeffrey V.Palayew, AdamCarrieri, PatriziaEkstedt, MattiasMarchesini, GiulioNovak, KatjaRatziu, VladRomero-Gómez, ManuelTacke, FrankZelber-Sagi, ShiraCortez-Pinto, HelenaAnstee, Quentin M.2023-03-14T16:40:42Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56662engJHEP Rep. 2021 Jan 21;3(2):10023410.1016/j.jhepr.2021.1002342589-5559info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:30Zoai:repositorio.ul.pt:10451/56662Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:13.227461Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? |
| title |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? |
| spellingShingle |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? Lazarus, Jeffrey V. Non-alcoholic fatty liver disease Liver health Multiple joint correspondence analysis Policy preparedness Health policy Metabolic-associated fatty liver disease Non-alcoholic steatohepatitis Europe |
| title_short |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? |
| title_full |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? |
| title_fullStr |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? |
| title_full_unstemmed |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? |
| title_sort |
European ‘NAFLD Preparedness Index’ — Is Europe ready to meet the challenge of fatty liver disease? |
| author |
Lazarus, Jeffrey V. |
| author_facet |
Lazarus, Jeffrey V. Palayew, Adam Carrieri, Patrizia Ekstedt, Mattias Marchesini, Giulio Novak, Katja Ratziu, Vlad Romero-Gómez, Manuel Tacke, Frank Zelber-Sagi, Shira Cortez-Pinto, Helena Anstee, Quentin M. |
| author_role |
author |
| author2 |
Palayew, Adam Carrieri, Patrizia Ekstedt, Mattias Marchesini, Giulio Novak, Katja Ratziu, Vlad Romero-Gómez, Manuel Tacke, Frank Zelber-Sagi, Shira Cortez-Pinto, Helena Anstee, Quentin M. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Lazarus, Jeffrey V. Palayew, Adam Carrieri, Patrizia Ekstedt, Mattias Marchesini, Giulio Novak, Katja Ratziu, Vlad Romero-Gómez, Manuel Tacke, Frank Zelber-Sagi, Shira Cortez-Pinto, Helena Anstee, Quentin M. |
| dc.subject.por.fl_str_mv |
Non-alcoholic fatty liver disease Liver health Multiple joint correspondence analysis Policy preparedness Health policy Metabolic-associated fatty liver disease Non-alcoholic steatohepatitis Europe |
| topic |
Non-alcoholic fatty liver disease Liver health Multiple joint correspondence analysis Policy preparedness Health policy Metabolic-associated fatty liver disease Non-alcoholic steatohepatitis Europe |
| description |
© 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01T00:00:00Z 2023-03-14T16:40:42Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/56662 |
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http://hdl.handle.net/10451/56662 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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JHEP Rep. 2021 Jan 21;3(2):100234 10.1016/j.jhepr.2021.100234 2589-5559 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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