Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/6495 |
Resumo: | EuSCAPE Working Group: Portugal - Manuela Caniça, Vera Manageiro |
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Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spreadBacterial ProteinsCarbapenem-Resistant EnterobacteriaceaeCross InfectionEnterobacteriaceae InfectionsEpidemicsEuropeHumansMolecular EpidemiologyPhylogenyPolymorphism, Single NucleotidePropensity ScoreSequence Analysis, DNAEuSCAPE Working Group: Portugal - Manuela Caniça, Vera ManageiroPublic health interventions to control the current epidemic of carbapenem-resistant Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. We analysed the genome sequences and epidemiological data of >1,700 K. pneumoniae samples isolated from patients in 244 hospitals in 32 countries during the European Survey of Carbapenemase-Producing Enterobacteriaceae. We demonstrate that carbapenemase acquisition is the main cause of carbapenem resistance and that it occurred across diverse phylogenetic backgrounds. However, 477 of 682 (69.9%) carbapenemase-positive isolates are concentrated in four clonal lineages, sequence types 11, 15, 101, 258/512 and their derivatives. Combined analysis of the genetic and geographic distances between isolates with different β-lactam resistance determinants suggests that the propensity of K. pneumoniae to spread in hospital environments correlates with the degree of resistance and that carbapenemase-positive isolates have the highest transmissibility. Indeed, we found that over half of the hospitals that contributed carbapenemase-positive isolates probably experienced within-hospital transmission, and interhospital spread is far more frequent within, rather than between, countries. Finally, we propose a value of 21 for the number of single nucleotide polymorphisms that optimizes the discrimination of hospital clusters and detail the international spread of the successful epidemic lineage, ST258/512.This work was funded by The Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus, Wellcome (grant nos. 098051 and 099202) and the NIHR Global Health Research Unit on Genomic Surveillance of Antimicrobial Resistance (NIHR 16/136/111). The EuSCAPE project was funded by ECDC through a specific framework contract (ECDC/2012/055) following an open call for tender (OJ/25/04/2012-PROC/2012/036).Nature Research (part of Springer Nature)Repositório Científico do Instituto Nacional de SaúdeDavid, SophiaReuter, SandraHarris, Simon R.Glasner, CorinnaFeltwell, TheresaArgimon, SilviaAbudahab, KhalilGoater, RichardGiani, TommasoErrico, GiuliaAspbury, MarianneSjunnebo, SaraEuSCAPE Working GroupESGEM Study GroupFeil, Edward J.Rossolini, Gian MariaAanensen, David M.Grundmann, Hajo2020-04-23T16:09:33Z2019-112019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6495engNat Microbiol . 2019 Nov;4(11):1919-1929. doi: 10.1038/s41564-019-0492-8. Epub 2019 Jul 292058-5276)10.1038/s41564-019-0492-8info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:43Zoai:repositorio.insa.pt:10400.18/6495Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:34.388766Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread |
| title |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread |
| spellingShingle |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread David, Sophia Bacterial Proteins Carbapenem-Resistant Enterobacteriaceae Cross Infection Enterobacteriaceae Infections Epidemics Europe Humans Molecular Epidemiology Phylogeny Polymorphism, Single Nucleotide Propensity Score Sequence Analysis, DNA |
| title_short |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread |
| title_full |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread |
| title_fullStr |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread |
| title_full_unstemmed |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread |
| title_sort |
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread |
| author |
David, Sophia |
| author_facet |
David, Sophia Reuter, Sandra Harris, Simon R. Glasner, Corinna Feltwell, Theresa Argimon, Silvia Abudahab, Khalil Goater, Richard Giani, Tommaso Errico, Giulia Aspbury, Marianne Sjunnebo, Sara EuSCAPE Working Group ESGEM Study Group Feil, Edward J. Rossolini, Gian Maria Aanensen, David M. Grundmann, Hajo |
| author_role |
author |
| author2 |
Reuter, Sandra Harris, Simon R. Glasner, Corinna Feltwell, Theresa Argimon, Silvia Abudahab, Khalil Goater, Richard Giani, Tommaso Errico, Giulia Aspbury, Marianne Sjunnebo, Sara EuSCAPE Working Group ESGEM Study Group Feil, Edward J. Rossolini, Gian Maria Aanensen, David M. Grundmann, Hajo |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
David, Sophia Reuter, Sandra Harris, Simon R. Glasner, Corinna Feltwell, Theresa Argimon, Silvia Abudahab, Khalil Goater, Richard Giani, Tommaso Errico, Giulia Aspbury, Marianne Sjunnebo, Sara EuSCAPE Working Group ESGEM Study Group Feil, Edward J. Rossolini, Gian Maria Aanensen, David M. Grundmann, Hajo |
| dc.subject.por.fl_str_mv |
Bacterial Proteins Carbapenem-Resistant Enterobacteriaceae Cross Infection Enterobacteriaceae Infections Epidemics Europe Humans Molecular Epidemiology Phylogeny Polymorphism, Single Nucleotide Propensity Score Sequence Analysis, DNA |
| topic |
Bacterial Proteins Carbapenem-Resistant Enterobacteriaceae Cross Infection Enterobacteriaceae Infections Epidemics Europe Humans Molecular Epidemiology Phylogeny Polymorphism, Single Nucleotide Propensity Score Sequence Analysis, DNA |
| description |
EuSCAPE Working Group: Portugal - Manuela Caniça, Vera Manageiro |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-11 2019-11-01T00:00:00Z 2020-04-23T16:09:33Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/6495 |
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http://hdl.handle.net/10400.18/6495 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Nat Microbiol . 2019 Nov;4(11):1919-1929. doi: 10.1038/s41564-019-0492-8. Epub 2019 Jul 29 2058-5276) 10.1038/s41564-019-0492-8 |
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info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Research (part of Springer Nature) |
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Nature Research (part of Springer Nature) |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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