Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/114328 |
Resumo: | PD/00193/2012 UIDB/04378/2020 UIDB/00068/2020 SFRH/BD/106032/2015 |
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Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticlesAtomic and Molecular Physics, and OpticsSDG 3 - Good Health and Well-beingPD/00193/2012 UIDB/04378/2020 UIDB/00068/2020 SFRH/BD/106032/2015Abstract: Halogenated uracil derivatives are of great interest in modern cancer therapy, either as chemotherapeutics or radiosensitisers depending on their halogen atom. This work applies UV-Vis spectroscopy to study the radiation damage of uracil, 5-bromouracil and 5-fluorouracil dissolved in water in the presence of gold nanoparticles upon irradiation with an Nd:YAG ns-pulsed laser operating at 532 nm at different fluences. Gold nanoparticles absorb light efficiently by their surface plasmon resonance and can significantly damage DNA in their vicinity by an increase of temperature and the generation of reactive secondary species, notably radical fragments and low energy electrons. A recent study using the same experimental approach characterized the efficient laser-induced decomposition of the pyrimidine ring structure of 5-bromouracil mediated by the surface plasmon resonance of gold nanoparticles. The present results show that the presence of irradiated gold nanoparticles decomposes the ring structure of uracil and its halogenated derivatives with similar efficiency. In addition to the fragmentation of the pyrimidine ring, for 5-bromouracil the cleavage of the carbon-halogen bond could be observed, whereas for 5-fluorouracil this reaction channel was inhibited. Locally-released halogen atoms can react with molecular groups within DNA, hence this result indicates a specific mechanism by which doping with 5-bromouracil can enhance DNA damage in the proximity of laser irradiated gold nanoparticles. Graphical abstract: [Figure not available: see fulltext.].DF – Departamento de FísicaCeFITec – Centro de Física e Investigação TecnológicaRUNMarques, Telma S.Śmiałek, Małgorzata A.Schürmann, RobinBald, IlkoRaposo, MariaEden, SamMason, Nigel J.2021-03-23T23:25:43Z2020-11-012020-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/114328eng1434-6060PURE: 26222154https://doi.org/10.1140/epjd/e2020-10208-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:56:56Zoai:run.unl.pt:10362/114328Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:29.551210Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles |
| title |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles |
| spellingShingle |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles Marques, Telma S. Atomic and Molecular Physics, and Optics SDG 3 - Good Health and Well-being |
| title_short |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles |
| title_full |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles |
| title_fullStr |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles |
| title_full_unstemmed |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles |
| title_sort |
Decomposition of halogenated nucleobases by surface plasmon resonance excitation of gold nanoparticles |
| author |
Marques, Telma S. |
| author_facet |
Marques, Telma S. Śmiałek, Małgorzata A. Schürmann, Robin Bald, Ilko Raposo, Maria Eden, Sam Mason, Nigel J. |
| author_role |
author |
| author2 |
Śmiałek, Małgorzata A. Schürmann, Robin Bald, Ilko Raposo, Maria Eden, Sam Mason, Nigel J. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
DF – Departamento de Física CeFITec – Centro de Física e Investigação Tecnológica RUN |
| dc.contributor.author.fl_str_mv |
Marques, Telma S. Śmiałek, Małgorzata A. Schürmann, Robin Bald, Ilko Raposo, Maria Eden, Sam Mason, Nigel J. |
| dc.subject.por.fl_str_mv |
Atomic and Molecular Physics, and Optics SDG 3 - Good Health and Well-being |
| topic |
Atomic and Molecular Physics, and Optics SDG 3 - Good Health and Well-being |
| description |
PD/00193/2012 UIDB/04378/2020 UIDB/00068/2020 SFRH/BD/106032/2015 |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-11-01 2020-11-01T00:00:00Z 2021-03-23T23:25:43Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/114328 |
| url |
http://hdl.handle.net/10362/114328 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1434-6060 PURE: 26222154 https://doi.org/10.1140/epjd/e2020-10208-3 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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