One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score

Detalhes bibliográficos
Autor(a) principal: Abrantes, Ana Mafalda
Data de Publicação: 2023
Outros Autores: Marques Da Silva, Bernardo, Branco, Carolina, Costa, Cláudia, Peres, Nadiesda, Cardoso, Ana, Sant’Ana, Mariana, Agapito Fonseca, José, Outerelo, Cristina, Resina, Cristina, Lopes, José António, Gameiro, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/59782
Resumo: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc ScoreCHA2D2SVAScHemodialysismortality© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Background: CKD is a significant cause of morbidity, cardiovascular and all-cause mortality. CHA2DS2-VASc is a score used in patients with atrial fibrillation to predict thromboembolic risk; it also appears to be useful to predict mortality risk. The aim of the study was to evaluate CHA2DS2-VASc scores as a tool for predicting one-year mortality after hemodialysis is started and for identifying factors associated with higher mortality. Methods: Retrospective analysis of patients who started hemodialysis between January 2014 and December 2019 in Centro Hospitalar Universitário Lisboa Norte. We evaluated mortality within one year of hemodialysis initiation. The CHA2DS2-VASc score was calculated at the start of hemodialysis. Results: Of 856 patients analyzed, their mean age was 68.3 ± 15.5 years and the majority were male (61.1%) and Caucasian (84.5%). Mortality within one-year after starting hemodialysis was 17.8% (n = 152). The CHA2DS2-VASc score was significantly higher (4.4 ± 1.7 vs. 3.5 ± 1.8, p < 0.001) in patients who died and satisfactorily predicted the one-year risk of mortality (AUC 0.646, 95% CI 0.6-0.7, p < 0.001), with a sensitivity of 71.7%, a specificity of 49.1%, a positive predictive value of 23.9% and a negative predictive value of 89.2%. In the multivariate analysis, CHA2DS2-VASc ≥3.5 (adjusted HR 2.24 95% CI (1.48-3.37), p < 0.001) and central venous catheter at dialysis initiation (adjusted HR 3.06 95% CI (1.93-4.85)) were significant predictors of one-year mortality. Conclusion: A CHA2DS2-VASc score ≥3.5 and central venous catheter at hemodialysis initiation were predictors of one-year mortality, allowing for risk stratification in hemodialysis patients.MDPIRepositório da Universidade de LisboaAbrantes, Ana MafaldaMarques Da Silva, BernardoBranco, CarolinaCosta, CláudiaPeres, NadiesdaCardoso, AnaSant’Ana, MarianaAgapito Fonseca, JoséOuterelo, CristinaResina, CristinaLopes, José AntónioGameiro, Joana2023-10-16T13:38:51Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59782engJ Clin Med. 2023 Jan 28;12(3):101110.3390/jcm120310112077-0383info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:08:48Zoai:repositorio.ul.pt:10451/59782Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:09:29.970217Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
title One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
spellingShingle One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
Abrantes, Ana Mafalda
CHA2D2SVASc
Hemodialysis
mortality
title_short One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
title_full One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
title_fullStr One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
title_full_unstemmed One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
title_sort One-year mortality after hemodialysis initiation: the prognostic role of the CHA2DS2-VASc Score
author Abrantes, Ana Mafalda
author_facet Abrantes, Ana Mafalda
Marques Da Silva, Bernardo
Branco, Carolina
Costa, Cláudia
Peres, Nadiesda
Cardoso, Ana
Sant’Ana, Mariana
Agapito Fonseca, José
Outerelo, Cristina
Resina, Cristina
Lopes, José António
Gameiro, Joana
author_role author
author2 Marques Da Silva, Bernardo
Branco, Carolina
Costa, Cláudia
Peres, Nadiesda
Cardoso, Ana
Sant’Ana, Mariana
Agapito Fonseca, José
Outerelo, Cristina
Resina, Cristina
Lopes, José António
Gameiro, Joana
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Abrantes, Ana Mafalda
Marques Da Silva, Bernardo
Branco, Carolina
Costa, Cláudia
Peres, Nadiesda
Cardoso, Ana
Sant’Ana, Mariana
Agapito Fonseca, José
Outerelo, Cristina
Resina, Cristina
Lopes, José António
Gameiro, Joana
dc.subject.por.fl_str_mv CHA2D2SVASc
Hemodialysis
mortality
topic CHA2D2SVASc
Hemodialysis
mortality
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023-10-16T13:38:51Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/59782
url http://hdl.handle.net/10451/59782
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Med. 2023 Jan 28;12(3):1011
10.3390/jcm12031011
2077-0383
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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