Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids

• Autor(a) principal: Long, Solida
• Data de Publicação: 2022
• Outros Autores: Duarte, Denise, Carvalho, Carla, Oliveira, Rafael, Santarém, Nuno, Palmeira, Andreia, Resende, Diana I. S. P., Silva, Artur M. S., Moreira, Rui, Kijjoa, Anake, Cordeiro Da Silva, Anabela, Nogueira, Fátima, Sousa, Emília, Pinto, Madalena M. M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/134564
• topic: Pyrazino[2,1- b]quinazoline-3,6-dione; antimalarial; P. falciparum; Leishmania; Trypanosoma brucei; Biochemistry, Genetics and Molecular Biology(all); Parasitology; Infectious Diseases; Pharmacology, Toxicology and Pharmaceutics(all); SDG 1 - No Poverty; SDG 3 - Good Health and Well-being; SDG 9 - Industry, Innovation, and Infrastructure; SDG 11 - Sustainable Cities and Communities; SDG 12 - Responsible Consumption and Production; SDG 13 - Climate Action; SDG 15 - Life on Land; SDG 17 - Partnerships for the Goals

Funding Information: This research was supported by national funds through FCT-Foundation for Science and Technology within the scope of UIDB/04423/2020, UIDP/04423/2020, IUD/04413/2020 and under the project PTDC/SAU-PUB/287336/2017 (reference POCI-01-0145-FEDER-028736), cofinanced by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds, as well as CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019. This work is a result of the project ATLANTIDA (reference NORTE-01-0145-FEDER-000040), supported by the Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement and through the European Regional Development Fund (ERDF). The work was also funded by FEDER-Fundo Europeu de Desenvolvimento Regional through COMPETE 2020-Programa Operacional para a Competitividade e Internacionalização (POCI), Portugal 2020, and by Portugese fundings through (FCT-Fundação para a Ciência e a Technologia/Ministério da Ciência, Technologia e Inovação, under the project “Instituto de Investigação e Inovação em Ciências da Saúde” “(POCI-01-0145-FEDER-007274)”. N.S. and C.C. are supported by Fundação e Ciência (MEC) cofunded by FEDER through the COMPETE 2020 Operational Programme for Competitiveness and Internationlisation (POCI) referent POCI-010-0145-FEDER-031013. S.L is thankful to Erasmus Mundus Action 2 (LOTUS+ LP15DF0205) for a full PhD scholarship and HEIP-RUPP-SGA-11 project. The authors thank Sara Cravo for technical support. Publisher Copyright: © The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00589.