Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal

Detalhes bibliográficos
Autor(a) principal: Otranto, Domenico
Data de Publicação: 2021
Outros Autores: Colella, Vito, Bezerra-santos, Marcos Antônio, Mendoza-roldan, Jairo Alfonso, Cavalera, Maria Alfonsa, Pereira, André, Schaper, Roland, Maia, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/116525
Resumo: Funding Information: The authors are grateful to Giada Annoscia and Riccardo Paolo Lia (Department of Veterinary Medicine, University of Bari, Italy) for their support during molecular identification and morphometric determination of the parasites. Funding Information: This study has been partially funded by Elanco Animal Health, Monheim, Germany. Publisher Copyright: © 2021, The Author(s).
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spelling Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from PortugalInfectious Diseasesveterinary(all)SDG 3 - Good Health and Well-beingSDG 12 - Responsible Consumption and ProductionSDG 15 - Life on LandFunding Information: The authors are grateful to Giada Annoscia and Riccardo Paolo Lia (Department of Veterinary Medicine, University of Bari, Italy) for their support during molecular identification and morphometric determination of the parasites. Funding Information: This study has been partially funded by Elanco Animal Health, Monheim, Germany. Publisher Copyright: © 2021, The Author(s).BACKGROUND: Onchocerca lupi and Cercopithifilaria spp. are vector-borne filarioids of dogs, which harbour skin microfilariae (mfs), the former being of zoonotic concern. Proper treatment studies using compounds with microfilaricidal activity have not been performed. Therefore, this study aimed to assess the efficacy of a commercially available spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of O. lupi or Cercopithifilaria spp. skin-dwelling mfs in naturally infected dogs. METHODS: Privately owned dogs (n = 393) from southern Portugal were sampled via skin biopsies to identify and count mfs in 20 µl of skin sediment. A total of 22 mfs-positive dogs were allocated to treatment group (n = 11; G1) or left untreated as a control (n = 11; G2). As a pilot investigation to test the treatment efficacy, five dogs assigned to G1 were treated four times at monthly intervals with moxidectin 2.5%/imidacloprid 10% spot-on formulation on SDs 0, 28 (± 2), 56 (± 2), and 84 (± 2). Based on the negative results for both O. lupi and/or Cercopithifilaria spp. mfs of dogs in the pilot study from SD28 onwards, the remaining six dogs in G1 were treated at SD0 and assessed only at SD28. RESULTS: Of the 393 animals sampled, 78 (19.8%) scored positive for skin-dwelling mfs. At the pilot investigation, a mean number of 19.6 mfs for O. lupi was recorded among five infected dogs whereas no mfs were detected at SD28. At SD0, the mean number of Cercopithifilaria spp. larvae was 12.6 for G1 and 8.7 for G2. The mean number of mfs for G2 was 20.09. CONCLUSIONS: Results herein obtained suggest that a single treatment with moxidectin 2.5%/imidacloprid 10% spot-on formulation is efficacious against skin-dwelling mfs in dogs. The microfilaricidal effect of moxidectin could also be useful in reducing the risk of O. lupi infection for humans.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNOtranto, DomenicoColella, VitoBezerra-santos, Marcos AntônioMendoza-roldan, Jairo AlfonsoCavalera, Maria AlfonsaPereira, AndréSchaper, RolandMaia, Carla2021-04-30T22:44:43Z2021-12-012021-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/116525eng1756-3305PURE: 29273873https://doi.org/10.1186/s13071-021-04704-7info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:10Zoai:run.unl.pt:10362/116525Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:07.277214Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
title Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
spellingShingle Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
Otranto, Domenico
Infectious Diseases
veterinary(all)
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
SDG 15 - Life on Land
title_short Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
title_full Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
title_fullStr Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
title_full_unstemmed Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
title_sort Efficacy of a spot-on formulation containing moxidectin 2.5%/imidacloprid 10% for the treatment of Cercopithifilaria spp. and Onchocerca lupi microfilariae in naturally infected dogs from Portugal
author Otranto, Domenico
author_facet Otranto, Domenico
Colella, Vito
Bezerra-santos, Marcos Antônio
Mendoza-roldan, Jairo Alfonso
Cavalera, Maria Alfonsa
Pereira, André
Schaper, Roland
Maia, Carla
author_role author
author2 Colella, Vito
Bezerra-santos, Marcos Antônio
Mendoza-roldan, Jairo Alfonso
Cavalera, Maria Alfonsa
Pereira, André
Schaper, Roland
Maia, Carla
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv Otranto, Domenico
Colella, Vito
Bezerra-santos, Marcos Antônio
Mendoza-roldan, Jairo Alfonso
Cavalera, Maria Alfonsa
Pereira, André
Schaper, Roland
Maia, Carla
dc.subject.por.fl_str_mv Infectious Diseases
veterinary(all)
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
SDG 15 - Life on Land
topic Infectious Diseases
veterinary(all)
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
SDG 15 - Life on Land
description Funding Information: The authors are grateful to Giada Annoscia and Riccardo Paolo Lia (Department of Veterinary Medicine, University of Bari, Italy) for their support during molecular identification and morphometric determination of the parasites. Funding Information: This study has been partially funded by Elanco Animal Health, Monheim, Germany. Publisher Copyright: © 2021, The Author(s).
publishDate 2021
dc.date.none.fl_str_mv 2021-04-30T22:44:43Z
2021-12-01
2021-12-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/116525
url http://hdl.handle.net/10362/116525
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1756-3305
PURE: 29273873
https://doi.org/10.1186/s13071-021-04704-7
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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