Cervical cancer outcome and tumor-associated macrophages: research evidence
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10284/11050 |
Resumo: | Inflammation is a key factor in cancer promotion. Tumor-associated macrophages (TAMs), as part of the tumor microenvironment, are often associated with the progression of tumors and a worse prognosis in many cancers, namely on cervical cancer. This work exhaustively summarizes the conclusions of the different studies published concerning TAMs function in cervical cancer, from in vitro studies using cancer cell lines to the clinical perspective (histological samples-based studies). Most studies have led to the conclusion that TAMs increased density is directly related to increased severity of a malignant cervical lesion. Additionally, TAMs are normally polarized into an M2 phenotype, benefiting and promoting tumor progression, resulting in a worse disease outcome. The tumor microenvironment is also a highly critical contributor that not only influences tumor natural history but also modulates the specific immune response. |
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Cervical cancer outcome and tumor-associated macrophages: research evidenceCervical cancerCancer cell linesCervical intraepithelial neoplasiaSquamous intraepithelial lesionTumor-associated macrophagesM1M2Inflammation is a key factor in cancer promotion. Tumor-associated macrophages (TAMs), as part of the tumor microenvironment, are often associated with the progression of tumors and a worse prognosis in many cancers, namely on cervical cancer. This work exhaustively summarizes the conclusions of the different studies published concerning TAMs function in cervical cancer, from in vitro studies using cancer cell lines to the clinical perspective (histological samples-based studies). Most studies have led to the conclusion that TAMs increased density is directly related to increased severity of a malignant cervical lesion. Additionally, TAMs are normally polarized into an M2 phenotype, benefiting and promoting tumor progression, resulting in a worse disease outcome. The tumor microenvironment is also a highly critical contributor that not only influences tumor natural history but also modulates the specific immune response.MDPIRepositório Institucional da Universidade Fernando PessoaHorta, BrunoPereira, ToméMedeiros, R.Cerqueira, Fátima2022-07-29T12:12:30Z2022-01-01T00:00:00Z2022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/11050engHorta B, Pereira T, Medeiros R, Cerqueira F. Cervical Cancer Outcome and Tumor-Associated Macrophages: Research Evidence. Immuno. 2022; 2(3):460-468. https://doi.org/10.3390/immuno203002810.3390/immuno20300282673-5601metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:10:21Zoai:bdigital.ufp.pt:10284/11050Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:47:48.097445Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cervical cancer outcome and tumor-associated macrophages: research evidence |
title |
Cervical cancer outcome and tumor-associated macrophages: research evidence |
spellingShingle |
Cervical cancer outcome and tumor-associated macrophages: research evidence Horta, Bruno Cervical cancer Cancer cell lines Cervical intraepithelial neoplasia Squamous intraepithelial lesion Tumor-associated macrophages M1 M2 |
title_short |
Cervical cancer outcome and tumor-associated macrophages: research evidence |
title_full |
Cervical cancer outcome and tumor-associated macrophages: research evidence |
title_fullStr |
Cervical cancer outcome and tumor-associated macrophages: research evidence |
title_full_unstemmed |
Cervical cancer outcome and tumor-associated macrophages: research evidence |
title_sort |
Cervical cancer outcome and tumor-associated macrophages: research evidence |
author |
Horta, Bruno |
author_facet |
Horta, Bruno Pereira, Tomé Medeiros, R. Cerqueira, Fátima |
author_role |
author |
author2 |
Pereira, Tomé Medeiros, R. Cerqueira, Fátima |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório Institucional da Universidade Fernando Pessoa |
dc.contributor.author.fl_str_mv |
Horta, Bruno Pereira, Tomé Medeiros, R. Cerqueira, Fátima |
dc.subject.por.fl_str_mv |
Cervical cancer Cancer cell lines Cervical intraepithelial neoplasia Squamous intraepithelial lesion Tumor-associated macrophages M1 M2 |
topic |
Cervical cancer Cancer cell lines Cervical intraepithelial neoplasia Squamous intraepithelial lesion Tumor-associated macrophages M1 M2 |
description |
Inflammation is a key factor in cancer promotion. Tumor-associated macrophages (TAMs), as part of the tumor microenvironment, are often associated with the progression of tumors and a worse prognosis in many cancers, namely on cervical cancer. This work exhaustively summarizes the conclusions of the different studies published concerning TAMs function in cervical cancer, from in vitro studies using cancer cell lines to the clinical perspective (histological samples-based studies). Most studies have led to the conclusion that TAMs increased density is directly related to increased severity of a malignant cervical lesion. Additionally, TAMs are normally polarized into an M2 phenotype, benefiting and promoting tumor progression, resulting in a worse disease outcome. The tumor microenvironment is also a highly critical contributor that not only influences tumor natural history but also modulates the specific immune response. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-07-29T12:12:30Z 2022-01-01T00:00:00Z 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10284/11050 |
url |
http://hdl.handle.net/10284/11050 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Horta B, Pereira T, Medeiros R, Cerqueira F. Cervical Cancer Outcome and Tumor-Associated Macrophages: Research Evidence. Immuno. 2022; 2(3):460-468. https://doi.org/10.3390/immuno2030028 10.3390/immuno2030028 2673-5601 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817553489072488448 |