The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination

Detalhes bibliográficos
Autor(a) principal: Adorno,Flora A.
Data de Publicação: 2020
Outros Autores: Lousada,Daniele Cristina F., Coelho,Karina M. P. A., França,Paulo Henrique C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100406
Resumo: ABSTRACT Introduction: The cervical cytological examination and the investigation of high-risk human papillomavirus (HPV) deoxyribonucleic acid (DNA) are well-known valuable tools for screening of cervical lesions, since they allow the early diagnosis of cancer and its precursor lesions. Objective: This study aimed to evaluate the ability of high-risk HPV DNA detection by hybrid capture to predict intraepithelial lesions and cancer in patients with initial cervical cytological diagnosis of atypical squamous cells (ASC). Method: Retrospective analysis of histological or cervical cytological results after one-year follow-up from hybrid capture for high-risk HPV DNA research in patients with previous ASC diagnosis. Sensitivity, specificity and positive and negative predictive values of hybrid capture were calculated in relation to the identification of squamous intraepithelial lesions. Results: Among the 163 patients previously diagnosed with ASC and absence of high-risk HPV DNA, nine (5.5%) showed low-grade (LSIL) or high-grade squamous intraepithelial lesion (HSIL) during the follow-up. On the other hand, among the 110 patients presenting ASC and high-risk HPV DNA positivity, 43 (39%) showed cervical lesions within one year. Sensitivity and specificity values and positive and negative predictive values applied to hybrid capture for the identification of squamous intraepithelial lesions were 82.3%, 69.3%, 38.1%, and 94.4%, respectively. Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative.
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spelling The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examinationcervical squamous cells of the atypiaearly detection of cancercervical intraepithelial neoplasiacervical squamous intraepithelial lesionspapillomavirus infectionsBrazilABSTRACT Introduction: The cervical cytological examination and the investigation of high-risk human papillomavirus (HPV) deoxyribonucleic acid (DNA) are well-known valuable tools for screening of cervical lesions, since they allow the early diagnosis of cancer and its precursor lesions. Objective: This study aimed to evaluate the ability of high-risk HPV DNA detection by hybrid capture to predict intraepithelial lesions and cancer in patients with initial cervical cytological diagnosis of atypical squamous cells (ASC). Method: Retrospective analysis of histological or cervical cytological results after one-year follow-up from hybrid capture for high-risk HPV DNA research in patients with previous ASC diagnosis. Sensitivity, specificity and positive and negative predictive values of hybrid capture were calculated in relation to the identification of squamous intraepithelial lesions. Results: Among the 163 patients previously diagnosed with ASC and absence of high-risk HPV DNA, nine (5.5%) showed low-grade (LSIL) or high-grade squamous intraepithelial lesion (HSIL) during the follow-up. On the other hand, among the 110 patients presenting ASC and high-risk HPV DNA positivity, 43 (39%) showed cervical lesions within one year. Sensitivity and specificity values and positive and negative predictive values applied to hybrid capture for the identification of squamous intraepithelial lesions were 82.3%, 69.3%, 38.1%, and 94.4%, respectively. Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative.Sociedade Brasileira de Patologia Clínica2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100406Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20200006info:eu-repo/semantics/openAccessAdorno,Flora A.Lousada,Daniele Cristina F.Coelho,Karina M. P. A.França,Paulo Henrique C.eng2020-03-12T00:00:00Zoai:scielo:S1676-24442020000100406Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2020-03-12T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false
dc.title.none.fl_str_mv The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
title The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
spellingShingle The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
Adorno,Flora A.
cervical squamous cells of the atypia
early detection of cancer
cervical intraepithelial neoplasia
cervical squamous intraepithelial lesions
papillomavirus infections
Brazil
title_short The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
title_full The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
title_fullStr The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
title_full_unstemmed The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
title_sort The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
author Adorno,Flora A.
author_facet Adorno,Flora A.
Lousada,Daniele Cristina F.
Coelho,Karina M. P. A.
França,Paulo Henrique C.
author_role author
author2 Lousada,Daniele Cristina F.
Coelho,Karina M. P. A.
França,Paulo Henrique C.
author2_role author
author
author
dc.contributor.author.fl_str_mv Adorno,Flora A.
Lousada,Daniele Cristina F.
Coelho,Karina M. P. A.
França,Paulo Henrique C.
dc.subject.por.fl_str_mv cervical squamous cells of the atypia
early detection of cancer
cervical intraepithelial neoplasia
cervical squamous intraepithelial lesions
papillomavirus infections
Brazil
topic cervical squamous cells of the atypia
early detection of cancer
cervical intraepithelial neoplasia
cervical squamous intraepithelial lesions
papillomavirus infections
Brazil
description ABSTRACT Introduction: The cervical cytological examination and the investigation of high-risk human papillomavirus (HPV) deoxyribonucleic acid (DNA) are well-known valuable tools for screening of cervical lesions, since they allow the early diagnosis of cancer and its precursor lesions. Objective: This study aimed to evaluate the ability of high-risk HPV DNA detection by hybrid capture to predict intraepithelial lesions and cancer in patients with initial cervical cytological diagnosis of atypical squamous cells (ASC). Method: Retrospective analysis of histological or cervical cytological results after one-year follow-up from hybrid capture for high-risk HPV DNA research in patients with previous ASC diagnosis. Sensitivity, specificity and positive and negative predictive values of hybrid capture were calculated in relation to the identification of squamous intraepithelial lesions. Results: Among the 163 patients previously diagnosed with ASC and absence of high-risk HPV DNA, nine (5.5%) showed low-grade (LSIL) or high-grade squamous intraepithelial lesion (HSIL) during the follow-up. On the other hand, among the 110 patients presenting ASC and high-risk HPV DNA positivity, 43 (39%) showed cervical lesions within one year. Sensitivity and specificity values and positive and negative predictive values applied to hybrid capture for the identification of squamous intraepithelial lesions were 82.3%, 69.3%, 38.1%, and 94.4%, respectively. Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100406
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/1676-2444.20200006
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dc.publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
instname:Sociedade Brasileira de Patologia (SBP)
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reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)
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repository.name.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)
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