The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100406 |
Resumo: | ABSTRACT Introduction: The cervical cytological examination and the investigation of high-risk human papillomavirus (HPV) deoxyribonucleic acid (DNA) are well-known valuable tools for screening of cervical lesions, since they allow the early diagnosis of cancer and its precursor lesions. Objective: This study aimed to evaluate the ability of high-risk HPV DNA detection by hybrid capture to predict intraepithelial lesions and cancer in patients with initial cervical cytological diagnosis of atypical squamous cells (ASC). Method: Retrospective analysis of histological or cervical cytological results after one-year follow-up from hybrid capture for high-risk HPV DNA research in patients with previous ASC diagnosis. Sensitivity, specificity and positive and negative predictive values of hybrid capture were calculated in relation to the identification of squamous intraepithelial lesions. Results: Among the 163 patients previously diagnosed with ASC and absence of high-risk HPV DNA, nine (5.5%) showed low-grade (LSIL) or high-grade squamous intraepithelial lesion (HSIL) during the follow-up. On the other hand, among the 110 patients presenting ASC and high-risk HPV DNA positivity, 43 (39%) showed cervical lesions within one year. Sensitivity and specificity values and positive and negative predictive values applied to hybrid capture for the identification of squamous intraepithelial lesions were 82.3%, 69.3%, 38.1%, and 94.4%, respectively. Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative. |
id |
SBP-1_a2cc30e5b15841604780dd8478f64d53 |
---|---|
oai_identifier_str |
oai:scielo:S1676-24442020000100406 |
network_acronym_str |
SBP-1 |
network_name_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository_id_str |
|
spelling |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examinationcervical squamous cells of the atypiaearly detection of cancercervical intraepithelial neoplasiacervical squamous intraepithelial lesionspapillomavirus infectionsBrazilABSTRACT Introduction: The cervical cytological examination and the investigation of high-risk human papillomavirus (HPV) deoxyribonucleic acid (DNA) are well-known valuable tools for screening of cervical lesions, since they allow the early diagnosis of cancer and its precursor lesions. Objective: This study aimed to evaluate the ability of high-risk HPV DNA detection by hybrid capture to predict intraepithelial lesions and cancer in patients with initial cervical cytological diagnosis of atypical squamous cells (ASC). Method: Retrospective analysis of histological or cervical cytological results after one-year follow-up from hybrid capture for high-risk HPV DNA research in patients with previous ASC diagnosis. Sensitivity, specificity and positive and negative predictive values of hybrid capture were calculated in relation to the identification of squamous intraepithelial lesions. Results: Among the 163 patients previously diagnosed with ASC and absence of high-risk HPV DNA, nine (5.5%) showed low-grade (LSIL) or high-grade squamous intraepithelial lesion (HSIL) during the follow-up. On the other hand, among the 110 patients presenting ASC and high-risk HPV DNA positivity, 43 (39%) showed cervical lesions within one year. Sensitivity and specificity values and positive and negative predictive values applied to hybrid capture for the identification of squamous intraepithelial lesions were 82.3%, 69.3%, 38.1%, and 94.4%, respectively. Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative.Sociedade Brasileira de Patologia Clínica2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100406Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online)instname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.5935/1676-2444.20200006info:eu-repo/semantics/openAccessAdorno,Flora A.Lousada,Daniele Cristina F.Coelho,Karina M. P. A.França,Paulo Henrique C.eng2020-03-12T00:00:00Zoai:scielo:S1676-24442020000100406Revistahttp://www.scielo.br/jbpmlhttps://old.scielo.br/oai/scielo-oai.php||jbpml@sbpc.org.br1678-47741676-2444opendoar:2020-03-12T00:00Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP)false |
dc.title.none.fl_str_mv |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination |
title |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination |
spellingShingle |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination Adorno,Flora A. cervical squamous cells of the atypia early detection of cancer cervical intraepithelial neoplasia cervical squamous intraepithelial lesions papillomavirus infections Brazil |
title_short |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination |
title_full |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination |
title_fullStr |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination |
title_full_unstemmed |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination |
title_sort |
The usefulness of high-risk HPV hybrid capture in patients with squamous cell atypia in cervical cytological examination |
author |
Adorno,Flora A. |
author_facet |
Adorno,Flora A. Lousada,Daniele Cristina F. Coelho,Karina M. P. A. França,Paulo Henrique C. |
author_role |
author |
author2 |
Lousada,Daniele Cristina F. Coelho,Karina M. P. A. França,Paulo Henrique C. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Adorno,Flora A. Lousada,Daniele Cristina F. Coelho,Karina M. P. A. França,Paulo Henrique C. |
dc.subject.por.fl_str_mv |
cervical squamous cells of the atypia early detection of cancer cervical intraepithelial neoplasia cervical squamous intraepithelial lesions papillomavirus infections Brazil |
topic |
cervical squamous cells of the atypia early detection of cancer cervical intraepithelial neoplasia cervical squamous intraepithelial lesions papillomavirus infections Brazil |
description |
ABSTRACT Introduction: The cervical cytological examination and the investigation of high-risk human papillomavirus (HPV) deoxyribonucleic acid (DNA) are well-known valuable tools for screening of cervical lesions, since they allow the early diagnosis of cancer and its precursor lesions. Objective: This study aimed to evaluate the ability of high-risk HPV DNA detection by hybrid capture to predict intraepithelial lesions and cancer in patients with initial cervical cytological diagnosis of atypical squamous cells (ASC). Method: Retrospective analysis of histological or cervical cytological results after one-year follow-up from hybrid capture for high-risk HPV DNA research in patients with previous ASC diagnosis. Sensitivity, specificity and positive and negative predictive values of hybrid capture were calculated in relation to the identification of squamous intraepithelial lesions. Results: Among the 163 patients previously diagnosed with ASC and absence of high-risk HPV DNA, nine (5.5%) showed low-grade (LSIL) or high-grade squamous intraepithelial lesion (HSIL) during the follow-up. On the other hand, among the 110 patients presenting ASC and high-risk HPV DNA positivity, 43 (39%) showed cervical lesions within one year. Sensitivity and specificity values and positive and negative predictive values applied to hybrid capture for the identification of squamous intraepithelial lesions were 82.3%, 69.3%, 38.1%, and 94.4%, respectively. Conclusion: Our results showed a high negative predictive value of hybrid capture for cervical lesions detection, in patients with previous diagnosis of ASC, when the high-risk HPV DNA research was negative. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100406 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/1676-2444.20200006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
publisher.none.fl_str_mv |
Sociedade Brasileira de Patologia Clínica |
dc.source.none.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial v.56 2020 reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) instname:Sociedade Brasileira de Patologia (SBP) instacron:SBP |
instname_str |
Sociedade Brasileira de Patologia (SBP) |
instacron_str |
SBP |
institution |
SBP |
reponame_str |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
collection |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) |
repository.name.fl_str_mv |
Jornal Brasileiro de Patologia e Medicina Laboratorial (Online) - Sociedade Brasileira de Patologia (SBP) |
repository.mail.fl_str_mv |
||jbpml@sbpc.org.br |
_version_ |
1752122297588645888 |