PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity

Detalhes bibliográficos
Autor(a) principal: Bianca Perez
Data de Publicação: 2012
Outros Autores: Catia Teixeira, Ines S Albuquerque, Jiri Gut, Philip J Rosenthal, Miguel Prudencio, Paula Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://repositorio-aberto.up.pt/handle/10216/82027
Resumo: Novel primaquine derivatives, obtained by conjugation of the drug's aliphatic amine with different cinnamic acids, resulted in increased in vitro activity, compared to primaquine, against liver-stage malarial parasites. The compounds were non-cytotoxic to human hepatoma cells, suggesting that they are a promising new class of agents for the treatment and prevention of malaria.
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spelling PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activityQuímicaChemical sciencesNovel primaquine derivatives, obtained by conjugation of the drug's aliphatic amine with different cinnamic acids, resulted in increased in vitro activity, compared to primaquine, against liver-stage malarial parasites. The compounds were non-cytotoxic to human hepatoma cells, suggesting that they are a promising new class of agents for the treatment and prevention of malaria.20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://repositorio-aberto.up.pt/handle/10216/82027eng2040-250310.1039/c2md20113eBianca PerezCatia TeixeiraInes S AlbuquerqueJiri GutPhilip J RosenthalMiguel PrudencioPaula Gomesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:15:41Zoai:repositorio-aberto.up.pt:10216/82027Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:19:15.380999Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
title PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
spellingShingle PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
Bianca Perez
Química
Chemical sciences
title_short PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
title_full PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
title_fullStr PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
title_full_unstemmed PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
title_sort PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
author Bianca Perez
author_facet Bianca Perez
Catia Teixeira
Ines S Albuquerque
Jiri Gut
Philip J Rosenthal
Miguel Prudencio
Paula Gomes
author_role author
author2 Catia Teixeira
Ines S Albuquerque
Jiri Gut
Philip J Rosenthal
Miguel Prudencio
Paula Gomes
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bianca Perez
Catia Teixeira
Ines S Albuquerque
Jiri Gut
Philip J Rosenthal
Miguel Prudencio
Paula Gomes
dc.subject.por.fl_str_mv Química
Chemical sciences
topic Química
Chemical sciences
description Novel primaquine derivatives, obtained by conjugation of the drug's aliphatic amine with different cinnamic acids, resulted in increased in vitro activity, compared to primaquine, against liver-stage malarial parasites. The compounds were non-cytotoxic to human hepatoma cells, suggesting that they are a promising new class of agents for the treatment and prevention of malaria.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio-aberto.up.pt/handle/10216/82027
url https://repositorio-aberto.up.pt/handle/10216/82027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2040-2503
10.1039/c2md20113e
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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