Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues

Detalhes bibliográficos
Autor(a) principal: Bianca C Perez
Data de Publicação: 2013
Outros Autores: Iva Fernandes, Nuno Mateus, Catia Teixeira, Paula Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/82169
Resumo: Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads.
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spelling Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analoguesCiências da saúdeHealth sciencesCinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads.20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/82169eng0960-894X10.1016/j.bmcl.2013.10.025Bianca C PerezIva FernandesNuno MateusCatia TeixeiraPaula Gomesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:20:26Zoai:repositorio-aberto.up.pt:10216/82169Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:38:51.226829Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
title Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
spellingShingle Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
Bianca C Perez
Ciências da saúde
Health sciences
title_short Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
title_full Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
title_fullStr Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
title_full_unstemmed Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
title_sort Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
author Bianca C Perez
author_facet Bianca C Perez
Iva Fernandes
Nuno Mateus
Catia Teixeira
Paula Gomes
author_role author
author2 Iva Fernandes
Nuno Mateus
Catia Teixeira
Paula Gomes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bianca C Perez
Iva Fernandes
Nuno Mateus
Catia Teixeira
Paula Gomes
dc.subject.por.fl_str_mv Ciências da saúde
Health sciences
topic Ciências da saúde
Health sciences
description Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/82169
url https://hdl.handle.net/10216/82169
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0960-894X
10.1016/j.bmcl.2013.10.025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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